P011: Patient-derived organoids as an epithelial model for preclinical IBD research and drug development.ECCO’23 CopenhagenYear: 2023
Authors: Frias, J.(1);Derksen, M.(1);Verissimo, C.S.(1);van Dooremalen, W.T.M.(1);Oldenburg, B.(2);Vries, R.G.J.(1);Boj, S.F.(1);Pourfarzad, F.(1);Pott, J.(1)*;
(1)HUB Organoids, Research and Development, Utrecht, The Netherlands;(2)University Medical Centre Utrecht, Department of Gastroenterology and Hepatology, Utrecht, The Netherlands;
P012: The administration of mm-miR-378a-3p exacerbates chronic inflammation and fibrosis in a murine intestinal modelECCO’23 CopenhagenYear: 2023
Authors: Seco-Cervera, M.(1)*;Argilés-Arberola, D.(2);Bauset, C.(2);Lis-López, L.(1);Coll, S.(2);Cosín-Roger, J.(1);Ortiz-Masià, D.(2);Calatayud, S.(2);Barrachina, M.D.(2);
(1)Hospital Dr Peset- FISABIO- Valencia- Spain., Dept. Pharmacology. School of Medicine and Dentistry. University of Valencia, Valencia, Spain;(2)Faculty of Medicine - University of Valencia, Pharmacology, Valencia, Spain;
P013: Role of IL-36RA mutations in Crohn's diseaseECCO’23 CopenhagenYear: 2023
Authors: Hecker, J.(1)*;Saurenbach, J.(1);Letizia, M.(1);Löscher , B.S.(2);Franke, A.(2);Kühl, A.A.(3);Atreya, R.(4);Koop, K.(4);Neufert, C.(4);Trajanoski , Z.(5);Schütz, A.(6);Siegmund, B.(1);Weidinger, C.(1);
(1)Charité- Universitätsmedizin Berlin, Department of Gastroenterology- Infectiology and Rheumatology, Berlin, Germany;(2)Christian-Albrechts-University of Kiel, Institute of Clinical Molecular Biology, Kiel, Germany;(3)Charité- Universitätsmedizin Berlin, Freie Universität Berlin and Humboldt Universität zu Berlin- iPATH.Berlin- Campus Benjamin Franklin, Berlin, Germany;(4)University Hospital Erlangen- Friedrich-Alexander University Erlangen-Nürnberg, Department of Medicine 1, Erlangen, Germany;(5)Medical University of Innsbruck, Biocenter- Institute of Bioinformatics, Innsbruck, Austria;(6)Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft MDC, Berlin- Germany, Berlin, Germany;
P014: Behaviour in mice with chronic DSS colitis mimics fatigue in IBD and is associated with neuroinflammationECCO’23 CopenhagenYear: 2023
Authors: Truyens, M.(1,2,3)*;Lernout, H.(1,2);Vandendriessche, C.(2,4,5);Bruggeman, A.(2,5,6);Xie, J.(2,4,5);De Vos, M.(1);Vermeirssen, V.(5,7,8);Vandenbroucke, R.(2,4,5);Laukens, D.(1,2,4);
(1)Ghent University, Department of Internal Medicine and Paediatrics, Ghent, Belgium;(2)Ghent University, VIB Centre for Inflammation Research IRC, Ghent, Belgium;(3)University Hospital Ghent, Department of Gastroenterology, Ghent, Belgium;(4)Ghent University, Ghent Gut Inflammation Group GGIG, Ghent, Belgium;(5)Ghent University, Department of Biomedical Molecular Biology, Ghent, Belgium;(6)Ghent University Hospital, Department of Neurology, Ghent, Belgium;(7)Cancer Research Institute Ghent CRIG, Lab for Computational Biology- Integromics and Gene Regulation CBIGR, Ghent, Belgium;(8)Ghent University, Department of Biomolecular Medicine, Ghent, Belgium;
P015: CITE-seq analysis revealed immune cell diversity in colonic mesenteric lymph nodes from IBD patientsECCO’23 CopenhagenYear: 2023
Authors: Wils, P.(1)*;Mehta, H.(2);rubio, M.(2);Sarfati, M.(2);Chapuy, L.(3);
(1)Claude Huriez Hospital- University of Lille 2, Hepato-Gastroenterology Department, Lille, France;(2)Centre de Recherche du Centre Hospitalier de l'Université de Montréal CRCHUM- University of Montreal, Immunoregulation Laboratory- Immunopathology Department, Montreal, Canada;(3)Montreal Children's Hospital- Research Institute of the McGill University Health Centre RI-MUHC- McGill University- Montreal- Qc- Canada, Department of Pediatrics, Montreal, Canada;
P016: Dietary supplementation with Brazilian jaboticaba-sabará fruit (Myrciaria jaboticaba (Vell.) O. Berg) ameliorates colitis-driven colorectal cancer in miceECCO’23 CopenhagenYear: 2023
Authors: Nascimento, R.D.P.D.(1)*;Rizzato, J.S.(1);Polezi, G.(1);Moya, A.M.T.M.(1);Silva, M.F.(2);Franchi Junior, G.C.(3);Borguini, R.G.(4);Santiago, M.C.P.D.A.(4);Paiotti, A.P.R.(5);Pereira, J.A.(6);Martinez, C.A.R.(6);Marostica Junior, M.R.(1);
(1)University of Campinas, Food Science and Nutrition, Campinas, Brazil;(2)Federal University of São Paulo, Biological Sciences, Diadema, Brazil;(3)University of Campinas, Medical Sciences, Campinas, Brazil;(4)Brazilian Agricultural Research Corporation, Embrapa Food Technology, Rio de Janeiro, Brazil;(5)Federal University of São Paulo, Medicine, São Paulo, Brazil;(6)São Francisco University, Postgraduate Program in Health Sciences, Bragança Paulista, Brazil;Laboratory of Nutrition and Metabolism
P017: Fecal wash host transcriptomics identifies inflammation throughout the colon and terminal ileumECCO’23 CopenhagenYear: 2023
Authors: Dan, S.(1);Ungar, B.(2)*;Ben-Moshe, S.(1);Bahar Halpern, K.(1);Yavzori, M.(2);Fudim, E.(2);Picard, O.(2);Abitbol, C.M.(2);Harnik, S.(2);Kopylov, U.(2);Ben-Horin, S.(2);Itzkovitz, S.(1);
(1)Weizmann Institute of Science, mcb, Rehovot, Israel;(2)Tel-HaShomer Sheba Medical Center, Department of Gastroenterology, Ramat Gan, Israel;Equal contribution
P018: Expression of annexin A1 and NLRP3 inflamassome in Chron's diseaseECCO’23 CopenhagenYear: 2023
Authors: Koga Ito, H.T.(1)*;Lice , I.(1);R. S. Sasso, G.(2);Artigiani, R.(3);D. Gil, C.(2);
(1)Federal University of São Paulo - UNIFESP, Department of Morphology and Genetics, São Paulo, Brazil;(2)Federal University of Sao Paulo – UNIFESP, Department of Morphology and Genetics, São Paulo, Brazil;(3)Federal University of Sao Paulo – UNIFESP, Department of Pathology, São Paulo, Brazil;
P019: Host-Enterobacteriaceae interactions and mitochondrial dysfunction in Crohn's colitisECCO’23 CopenhagenYear: 2023
Authors: Holani, R.(1)*;Bar-Yoseph, H.(2);Krekhno, Z.(3);Moon, K.M.(4);Stacey, R.G.(4);Serapio-Palacios, A.(3);Bressler, B.(5);Donald, K.(6);Foster, L.J.(7);Finlay, B.B.(3);
(1)University of British Columbia, Michael Smith Laboratory- Microbiology and Immunology, Vancouver- British Columbia, Canada;(2)Rambam Health Care Campus, Gastroenterology, Haifa, Israel;(3)University of British Columbia, Michael Smith Laboratory- Microbiology and Immunology, Vancouver, Canada;(4)University of British Columbia, Michael Smith Laboratory- Biochemistry and Molecular Biology, Vancouver, Canada;(5)University of British Columbia, Division of Gastroenterology, Vancouver, Canada;(6)University of British Columbia, Michael Smith Laboratory- Microbiology and Immunolgy, Vancouver, Canada;(7)University of British Columbia, Michael Smith Laboratory- Biochemistry and Molecular Biology, Vanocuver, Canada;
P020: Characterisation of mucus in patients with Crohn's diseaseECCO’23 CopenhagenYear: 2023
Authors: Kramer, C.(1)*;Ziegler, J.(1);Alzain, N.(1);Schroeter, S.(1);Almalla, A.(2);Elomaa, L.(2);Addante, A.(3);Kuppe, A.(3);Fentker, K.(4);Nazat Martinez Medina, J.(5);Jarquin-Diaz, V.H.(5);Rulff, H.(6);Gradzielski, M.(6);Forslund, S.(5);Mertins, P.(4);Mall, M.(3);Weinhart, M.(2);Glauben, R.(1);Siegmund, B.(1);
(1)Charité - Universitätsmedizin Berlin, Medical Department of Gastroenterology- Infectiology and Rheumatology, Berlin, Germany;(2)Freie Universität Berlin, Institute of Chemistry and Biochemistry, Berlin, Germany;(3)Charité - Universitätsmedizin Berlin, Department of Pediatric Respiratory Medicine- Immunology and Critical Care Medicine, Berlin, Germany;(4)Max Delbrück Center for Molecular Medicine in the Helmholtz Society and Berlin Institute of Health, Proteomics, Berlin, Germany;(5)Max Delbrück Center for Molecular Medicine and Charité University Hospital, Forslund group, Berlin, Germany;(6)Stranski-Laboratorium für Physikalische und Theoretische Chemie, Institut für Chemie, Berlin, Germany;
P021: Microbial metabolite receptors as mediators of pathogenic processes in Inflammatory Bowel Disease.ECCO’23 CopenhagenYear: 2023
Authors: Spathakis, M.(1,2)*;Dovrolis, N.(1,2);Tarapatzi, G.(1,2);Filidou , E.(1,2);Kandilogiannakis, L.(1,2);Valatas, V.(1,3);Drygiannakis, I.(3);Manolopoulos, V.G.(1,2);Kolios, G.(1,2);Arvanitidis, K.(1,2);Vradelis, S.(4);
(1)Democritus University of Thrace, Laboratory of Pharmacology- Department of Medicine, Alexandroupolis, Greece;(2)Democritus University of Thrace, Individualised Medicine & Pharmacological Research Solutions Center IMPReS, Alexandroupolis, Greece;(3)University of Crete, Gastroenterology and Hepatology Research Laboratory- Department of Medicine, Heraklion, Greece;(4)Democritus University of Thrace, Department of Internal Medicine- Department of Medicine, Alexandroupolis, Greece;
P023: Immune-metabolic profiles of creeping fat in relation to degree of severity in Crohn's disease postsurgical recurrence.ECCO’23 CopenhagenYear: 2023
Authors: Suau, R.(1,2)*;Pardina, E.(3);López-Tejero, M.D.(3);Lorén, V.(1,2);Zabana, Y.(2,4);Llaves, M.(1);Cordobilla, B.(3);Cañete, F.(2,5);Guasch, M.(6);Ricart-Jané, D.(3);Mañosa, M.(2,5);Domènech, E.(2,5);Domingo, J.C.(3);Manyé, J.(1,2);
(1)Institut d'Investigació Germans Trias i Pujol IGTP, IBD Research Group, Badalona, Spain;(2)Centro de Investigación Biomédica en Red, Enfermedades Hepáticas y Digestivas CIBEREHD, Madrid, Spain;(3)Universitat de Barcelona, Biochemistry and Molecular Biology Department, Barcelona, Spain;(4)Hospital Universitari Mútua Terrassa, Gastroenterology Departament- IBD Unit, Terrassa, Spain;(5)Hospital Universitari Germans Trias i Pujol HUGTP, Gastroenterology Department, Badalona, Spain;(6)Hospital Parc Sanitari Sant Joan de Déu, Surgery Department, Sant Boi de Llobregat, Spain;
P024: Effects of anti-TNF and anti-interleukins 12 and 23 drugs on circulating dendritic cells migratory capacity in inflammatory bowel diseaseECCO’23 CopenhagenYear: 2023
Authors: Soleto, I.(1)*;Ramirez, C.(1);Gómez, C.(1);Montse, B.(1);García, S.(1);Orejudo, M.(1);Mecado, J.(1);Chaparro, M.(1);P. Gisbert, J.(1);
(1)Hospital Universitario de La Princesa- Instituto de Investigación Sanitaria Princesa IIS-Princesa- Universidad Autónoma de Madrid UAM- and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas CIBERehd- Madrid. Spain, gastrointestinal unit, Madrid, Spain;
P025: Colonic rather than ileal expression of ITGA4/ITGB7 correlates with local intestinal inflammation in IBDECCO’23 CopenhagenYear: 2023
Authors: Csomor, E.(1)*;Gehrmann, U.(2);Monkley, S.(2);Tian, S.(1);Cairns, J.(2);Angermann, B.(2);Khan, E.(3);Nys, J.(4);Marks, D.(5);
(1)AstraZeneca, Translational Science & Experimental Medicine- Research and Early Development- Respiratory and Immunology R&I, Cambridge, United Kingdom;(2)AstraZeneca, Translational Science & Experimental Medicine- Research and Early Development- Respiratory and Immunology R&I, Gothenburg, Sweden;(3)AstraZeneca, Late Clinical Development- Respiratory and Immunology R&I, Cambridge, United Kingdom;(4)AstraZeneca, Bioscience Asthma- Research and Early Development- Respiratory and Immunology R&I, Cambridge, United Kingdom;(5)AstraZeneca, Early Clinical Development- Respiratory and Immunology R&I, Cambridge, United Kingdom;
P026: Cost per Response/Remission analysis of biologic therapies availables in Argentina for the treatment of Bio-exposed patients with moderate-to-severe active Ulcerative ColitisECCO’23 CopenhagenYear: 2023
Authors: Elgart, J.(1);Balderramo, S.(2);Calvi, G.(3);Kanevsky, D.(3);Sánchez Gonzalez, Y.(4)*;
(1)CENEXA. Center of Experimental and Applied Endocrinology, Health Economics, La Plata, Argentina;(2)Hospital Privado Universitario de Cordoba, Gastroenterology Department, Cordoba, Argentina;(3)AbbVie Argentina, Market Access, Buenos Aires, Argentina;(4)AbbVie Inc., HEOR Strategy – Ulcerative Colitis, Chicago, United States;
P027: Anorectal Motility Disorders in Inflammatory Bowel Disease patientsECCO’23 CopenhagenYear: 2023
Authors: Costache, R.(1)*;Dimitriu, A.(1,2);Les, A.(1);Gheorghe, C.(1,2);
(1)Fundeni Clinical Institute, Gastroenterology and Hepatology, Bucharest, Romania;(2)“Carol-Davila” University of Medicine and Pharmacy, Gastroenterology, Bucharest, Romania;
P028: Transitioning patients from intravenous to subcutaneous infliximab and vedolizumab for inflammatory bowel disease – what is the opportunity cost of improving access to health care?ECCO’23 CopenhagenYear: 2023
Authors: Hilley, P.(1,2)*;Wong, D.(1,3);Ma, R.(4);Peterson, A.(1);De Cruz, P.(1,3);
(1)AUSTIN HEALTH, Department of Gastroenterology, Melbourne, Australia;(2)University of Melbourne, Melbourne Academic Centre for Health, Melbourne, Australia;(3)University of Melbourne, Department of Medicine- Austin Academic Centre, Melbourne, Australia;(4)Austin Health, Business Intelligence Unit, Melbourne, Australia;
P029: Histopathological characterization of a chronic DSS-induced mouse model of IBD with intestinal fibrosisECCO’23 CopenhagenYear: 2023
Authors: Nielsen, M.H.(1)*;Zachariassen, L.F.(1);Sárvári, A.K.(2);Marstrand-Jørgensen, A.B.(3);Hansen, H.H.(4);Feigh, M.(4);
(1)Gubra, In vivo pharmacology, Hørsholm, Denmark;(2)Gubra, Tissue research, Hørsholm, Denmark;(3)Gubra, Assay & NGS, Hørsholm, Denmark;(4)Gubra, Sales & Marketing, Hørsholm, Denmark;
