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University of Edinburgh, MRC Centre for Inflammation Research, Edinburgh, United Kingdom

P055

Mitochondrial DNA is a damage-associated molecular pattern released during active IBD promoting TLR9-mediated inflammation

Year: 2017
Source:

University of Edinburgh, MRC Centre for Inflammation Research, Edinburgh, United Kingdom

Authors:

Boyapati R., Dorward D., Tamborska A., Kalla R., Ventham N., Rossi A., Satsangi J., Ho G.-T.

P056

Evaluation of oxidative stress in experimental model of Chron’s disease under hyperbaric oxygen treatment

Year: 2016
Authors:

F. S. Nakutis1, I. Nishitokukado1, F. M. d. Santos1, C. Ortiz-Agostinho1, V. S. Nunes2, A. Zonetti1, A. Sipahi*1

1Faculdade de Medicina da USP, Gastroenterologia Lim07, São Paulo, Brazil, 2Universidade de Medicina da USP, Laboratório Lípides, São Paulo, Brazil

1University of Birmingham, Institute of Cancer and Genomic Sciences, Birmingham, United Kingdom 2University Hospital Birmingham, Department of Gastroenterology, Birmingham, United Kingdom 3University of Birmingham, Institute of Microbiology and Infection, Birmingham, United Kingdom 4Kings College London, Twin Research & Genetic Epidemiology, London, United Kingdom 5University Hospital Birmingham, Institute of Translational Medicine, Birmingham, United Kingdom

P056

Gut microbiota characterisation in South Asian IBD patients resident in the UK

Year: 2017
Source:

1University of Birmingham, Institute of Cancer and Genomic Sciences, Birmingham, United Kingdom 2University Hospital Birmingham, Department of Gastroenterology, Birmingham, United Kingdom 3University of Birmingham, Institute of Microbiology and Infection, Birmingham, United Kingdom 4Kings College London, Twin Research & Genetic Epidemiology, London, United Kingdom 5University Hospital Birmingham, Institute of Translational Medicine, Birmingham, United Kingdom

Authors:

Quraishi M.N.*1,2, Rossiter A.3, Bhala N.2, Beaumont M.4, Pathmakanthan S.2, Ghosh S.2,5, Iqbal T.H.1,2

P057

HLA B27 transgenic rat: a new animal model of postsurgical ileitis in inflammatory bowel disease

Year: 2016
Authors:

A. Chau*1, C. Chater1, S. Speca2, M. Djouina2, C. Dubuquoy2, L. Dubuquoy2, C. Neut3, D. Koriche1, P. Zerbib1, F.R. Pruvot1, P. Desreumaux4, B. Pariente4

1Lille University North of France, INSERM U995, Department of Digestive Surgery and Transplantation, CHRU Lille, Lille, France, 2Lille University North of France, INSERM U995, CHRU Lille, Lille, France, 3Lille University North of France, INSERM U995, Department of Microbiology, Faculty of Pharmacy, Lille, France, 4Hepato-Gastroenterology Department, Claude Huriez Hospital, University of Lille 2, Inserm Unit 995, University of Lille 2, Lille, France

1Yeungnam University, College of Pharmacy, Gyeongsan, South Korea 2Hanyang University, College of Pharmacy, Ansan, South Korea

P057

IL-6 induces NLRP3 inflammasome activation through JAK/STAT3-dependent NOX2 induction in colon epithelial cells

Year: 2017
Source:

1Yeungnam University, College of Pharmacy, Gyeongsan, South Korea 2Hanyang University, College of Pharmacy, Ansan, South Korea

Authors:

Kim J.-A.*1, Grung P.1, Banskota S.1, Jeong B.-S.1, Nam T.-g.2

P058

Bacterial activation of thioguanine results in lymphocyte independent improvement in murine colitis

Year: 2016
Authors:

I. Oancea1, 2, I. Das1, D. Aguirre de Cárcer3, R. Movva1, 4, V. Schreiber1, Y. Yang1, 5, M. Proctor1, R. Wang1, Y. Sheng1, M. Lobb1, P. Ó Cuiv6, J. A. Duley1, 4, J. Begun*2, 7, T. H. J. Florin1, 2

1University of Queensland, Mater Research Institute, Brisbane, Australia, 2University of Queensland, School of Medicine, Brisbane, Australia, 3CSIRO, Preventative Health National Research Flagship and Division of Livestock Industries, Brisbane, Australia, 4Griffith University, School of Pharmacy, Gold Coast, Australia, 5University of Queensland, School of Pharmacy, Brisbane, Australia, 6University of Queensland, Diamantina Institute, Brisbane, Australia, 7University of Queensland, Mater Research Institute, South Brisbane, Australia

1University of Manchester, School of Medical Sciences, Manchester, United Kingdom 2Origin Sciences, Cambridge, United Kingdom 3statistics@petertreasure.com, King's Lynn, United Kingdom

P058

Comparison of Calprotectin levels in stool and rectal mucus in subjects with suspected or confirmed inflammatory bowel disease

Year: 2017
Source:

1University of Manchester, School of Medical Sciences, Manchester, United Kingdom 2Origin Sciences, Cambridge, United Kingdom 3statistics@petertreasure.com, King's Lynn, United Kingdom

Authors:

McLaughlin J.*1, Hedley A.D.2, Treasure P.3, Collins C.M.2, Craven R.A.2

1The Blizard Institute, Queen Mary University of London, Centre for Immunobiology, London, United Kingdom 2Barts Health NHS Trust, Department of Gastroenterology, London, United Kingdom

P059

Mucosal inflammation promotes activation of circulating Vδ2+ T-cells in Crohn's disease

Year: 2017
Source:

1The Blizard Institute, Queen Mary University of London, Centre for Immunobiology, London, United Kingdom 2Barts Health NHS Trust, Department of Gastroenterology, London, United Kingdom

Authors:

McCarthy N.*1, Gordon H.1, Rahman S.1, Harrow P.1,2, Stagg A.1, Lindsay J.1,2

P059

Two new genetic mouse models for ulcerative colitis based on lateral tight junction disruption.

Year: 2016
Authors:

W. Stremmel*1, S. Staffer2, M. Schneider3, H. Gan-Schreier2, A. Wannhoff2, A. Gauss4, H. Wolburg5, M. Bach6, A. Swidsinski7, T. Efferth3

1University Hospital of Heidelberg, Internal Medicine IV, Dept. of Gastroenterology, Heidelberg, Germany, 2University Hospital of Heidelberg, Internal Medicine IV, Div. of Gastroenterology, Heidelberg, Germany, 3Johannes Gutenberg University, Institute of Pharmacy & Biochemistry, Mainz, Germany, 4University Hospital of Heidelberg, Gastroenterology, Heidelberg, Germany, 5University Medical School Tuebingen, Pathology and Neuropathology, Tuebingen, Germany, 6Kirchhoff Institute of Physics, Physics, Heidelberg, Germany, 7Charité - University Hospital Berlin, Berlin, Germany

P060

Alterations of brain structure in Crohn’s disease with extraintestinal manifestations

Year: 2016
Authors:

A. Thomann*1, W. Reindl2, P. Thomann3, C. Wolf4, D. Hirjak3, M. Griebe5

1Universitätsmedizin Mannheim, Department of Medicine II, Mannheim, Germany, 2Universitätsmedizin Mannheim, Department of Medicine II, Mannheim, Germany, 3Universitätsklinik Heidelberg, Department of Psychiatry, Heidelberg, Germany, 4Universität des Saarlandes, Department of Psychiatry, Psychotherapy and Psychosomatic Medicine, Homburg/Saar, Germany, 5Universitätsmedizin Mannheim, Department of Neurology, Mannheim, Germany

Hanyang University Guri Hospital, Gastroenterology, Guri, South Korea

P060

Role of innate lymphoid cells in the chronic colitis under anti-il-17a therapy

Year: 2017
Source:

Hanyang University Guri Hospital, Gastroenterology, Guri, South Korea

Authors:

Eun C.S., Han D.S., Park C.H., Lee A.R., Lee Y.R.

P061

Creeping fat contains a unique T-cell compartment with potential impact on intestinal inflammation

Year: 2016
Authors:

L. I. Kredel*1, L. J. Jödicke1, A. A. Kuehl1, I. Freise1, J. Gröne2, B. Siegmund1

1Charité Universitätsmedizin Berlin, Campus Benjamin Franklin, Gastroenterology, Infectiology and Rheumatology, Berlin, Germany, 2Charité Universitätsmedizin Berlin, Campus Benjamin Franklin, General, Vascular and Thoracic Surgery, Berlin, Germany

1University of Edinburgh, Institute of Genetics and Molecular Medicine, Edinburgh, United Kingdom 2University of Oslo, Institute of Clinical Medicine, EpiGen, Campus Ahus, Oslo, Norway 3BioCruces Health Research Institue, Bilbao, Spain 4Akershus University, Department of Gastroenterology, Akershus, Norway 5Örebro University, Department of Gastroenterology, Faculty of Medicine and Health, Örebro, Sweden 6Linköping University Hospital, Department of Surgery, Linköping, Sweden 7Maastricht University Medical Center (MUMC), Department of Gastroenterology and Hepatology, Maastricht, Netherlands 8Karolinska Institute, Department of Clinical Science, Intervention and Technology, Stockholm, Sweden 9University Hospital Clinic Lozano Blesa, Zaragoza, Spain 10CNAG-CRG Centre for Genomic Regulation, Barcelona Institute of Science and Technology, Barcelona, Spain

P061

Epigenetic alterations at diagnosis predict susceptibility, prognosis and treatment escalation in inflammatory bowel disease – IBD Character

Year: 2017
Source:

1University of Edinburgh, Institute of Genetics and Molecular Medicine, Edinburgh, United Kingdom 2University of Oslo, Institute of Clinical Medicine, EpiGen, Campus Ahus, Oslo, Norway 3BioCruces Health Research Institue, Bilbao, Spain 4Akershus University, Department of Gastroenterology, Akershus, Norway 5Örebro University, Department of Gastroenterology, Faculty of Medicine and Health, Örebro, Sweden 6Linköping University Hospital, Department of Surgery, Linköping, Sweden 7Maastricht University Medical Center (MUMC), Department of Gastroenterology and Hepatology, Maastricht, Netherlands 8Karolinska Institute, Department of Clinical Science, Intervention and Technology, Stockholm, Sweden 9University Hospital Clinic Lozano Blesa, Zaragoza, Spain 10CNAG-CRG Centre for Genomic Regulation, Barcelona Institute of Science and Technology, Barcelona, Spain

Authors:

Adams A.*1, Kalla R.1, Vatn S.2, Bonfiglio F.3, Nimmo E.1, Kennedy N.1, Ventham N.1, Vatn M.2, Ricanek P.4, Bergemalm D.5, Halfvarson J.5, Söderholm J.6, Pierik M.7, Törkvist L.8, Gomollόn F.9, Gut I.10, Jahnsen J.2, Satsangi J.1 IBD Character Consortium

P062

Critical role of the IL-33/ST2 axis in colitis-associated colorectal cancer

Year: 2016
Authors:

L. R. Lopetuso*1, 2, 3, C. De Salvo3, L. Di Martino3, W. Goodman3, F. Scaldaferri2, A. Gasbarrini2, T. T. Pizarro3

1Catholic University of the Sacread Hearth, Internal Medicine, Gastroenterology Division, Rome, Italy, 2Catholic University of Sacred Heart, Internal Medicine Department, Gastroenterology Division, Rome, Italy, 3Case Western Reserve University, Pathology, Cleveland, United States

Topivert Pharma Ltd, London, United Kingdom

P062

The narrow spectrum kinase inhibitor TOP1288 demonstrates potent anti-inflammatory effects in a T cell adoptive transfer colitis model through a topical mode of action

Year: 2017
Source:

Topivert Pharma Ltd, London, United Kingdom

Authors:

Solanke Y., Foster M., Fyfe M., Rowley A., Sirohi S., Webber S., Walshe C.

P063

Dissecting the role of rage in intestinal fibrosis

Year: 2016
Authors:

S. Speca*1, M. Body-Malapel1, C. Fradin1, M. Djouina1, E. Boulanger1, A.-M. Schmidt2, P. Desreumaux1, C. Vignal1

1Centre Hospitalier Régional Universitaire de Lille, Lille, France, 2NYU Langone Medical Centre, Departments of Medicine (Endocrinology Div), Biochemistry and Molecular Pharmacology and Pathology (Pathology) , New York, United States

Charité - Universitätsmedizin Berlin, Medical department for Gastroenterology, Infectious Diseases and Rheumatology, Berlin, Germany

P063

HDAC as versatile regulators of the intestinal epithelial barrier in inflammatory bowel disease

Year: 2017
Source:

Charité - Universitätsmedizin Berlin, Medical department for Gastroenterology, Infectious Diseases and Rheumatology, Berlin, Germany

Authors:

Friedrich M., Ganther J., Breiderhoff T., Rosenthal R., Glauben R., Siegmund B.

1University of Zurich, Zurich, Switzerland 2Novartis Institutes for BioMedical Research, Basel, Switzerland

P064

EBI2 and oxysterols in the development of intestinal lymphoid structures and colitis

Year: 2017
Source:

1University of Zurich, Zurich, Switzerland 2Novartis Institutes for BioMedical Research, Basel, Switzerland

Authors:

Wyss A.*1, Raselli T.1, Schmelczer G.1, Spalinger M.1, Atrott K.1, Frey-Wagner I.1, Sailer A.W.2, Rogler G.1, Misselwitz B.1

P064

TOP1210 narrow spectrum kinase inhibitor demonstrates superior activity and improved safety profile potential compared with corticosteroid and immunomodulators in preclinical models of colitis

Year: 2016
Authors:

C. A. Walshe*, A. Rowley, M. R. Foster, Y. Solanke, S. Sirohi, 
M. C. Fyfe, S. Webber

Topivert Pharma Ltd, London, United Kingdom

1Charité - Universitätsmedizin Berlin, Medical Department for Gastroenterology, Infectious Diseases and Rheumatology, Berlin, Germany 2German Institute of Human Nutrition Potsdam-Rehbruecke, Department of Gastrointestinal Microbiology, Nuthetal, Germany 3Takeda Pharma Vertrieb GmbH & Co. KG, Berlin, Germany 4Max Rubner-Institute, Institute of Physiology and Biochemistry of Nutrition, Nutrition and Intestinal Microbiota, Karlsruhe, Germany

P065

Effects of gut bacteria on the intestinal immune cell composition and barrier function

Year: 2017
Source:

1Charité - Universitätsmedizin Berlin, Medical Department for Gastroenterology, Infectious Diseases and Rheumatology, Berlin, Germany 2German Institute of Human Nutrition Potsdam-Rehbruecke, Department of Gastrointestinal Microbiology, Nuthetal, Germany 3Takeda Pharma Vertrieb GmbH & Co. KG, Berlin, Germany 4Max Rubner-Institute, Institute of Physiology and Biochemistry of Nutrition, Nutrition and Intestinal Microbiota, Karlsruhe, Germany

Authors:

Schmidt F.*1, Dahlke K.2, Batra A.1,3, Ring C.2, Keye J.1, Loh G.2,4, Schumann M.1, Kühl A.1, Blaut M.2, Siegmund B.1

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