P084: Secreted inflammatory protein profiles following treatment of ex-vivo human Ulcerative Colitis and Crohn’s Disease explants with licenced biologic therapiesECCO'22Year: 2022
Authors: Corcoran, R.(1);O'Connell, F.(2);O'Sullivan, J.(2);Kevans, D.(1);
(1)St James’s Hospital, Department of Gastroenterology, Dublin, Ireland;(2)Trinity Translational Medicine Institute- Trinity College Dublin- Ireland, Department of Surgery, Dublin, Ireland;
P085: Paneth cells translate dietary lipid exposure into gut inflammationECCO'22Year: 2022
Authors: Grabherr, F.(1);Meyer, M.(1);Schmitz, J.J.(1);Schwärzler, J.(1);Mayr, L.(1);Philipp, M.(1);Jukic, A.(1);Grander, C.(1);Tilg, H.(1);Adolph, T.E.(1);
(1)Medizinische Universität Innsbruck, Innere Medizin 1 - Gastroenterologie- Hepatologie und Endokrinologie, Innsbruck, Austria;
P086: Mucosal microbiota modulate host intestinal immune signatures in Inflammatory Bowel DiseaseECCO'22Year: 2022
Authors: Hu, S.(1,2);Bourgonje, A.R.(1);Gacesa, R.(1,2);Jansen, B.H.(1);Bangma, A.(1);Hidding, I.(1,2);Festen, E.A.M.(1);van Dullemen, H.M.(1);Visschedijk, M.C.(1);Dijkstra, G.(1);Harmsen, H.J.M.(3);Vich Vila, A.(1,2);Spekhorst, L.M.(1,4);Weersma, R.K.(1);
(1)University of Groningen- University Medical Center Groningen, Gastroenterology and Hepatology, Groningen, The Netherlands;(2)University of Groningen- University Medical Center Groningen, Genetics, Groningen, The Netherlands;(3)University of Groningen- University Medical Center Groningen, Medical Microbiology, Groningen, The Netherlands;(4)Medisch Spectrum Twente, Gastroenterology and Hepatology, Enschede, The Netherlands;
P087: Communicating Needs and Features of IBD Experiences (CONFIDE) Survey: Impact of Ulcerative Colitis Symptoms on Daily LifeECCO'22Year: 2022
Authors: Dubinsky, M.C.(1);Schreiber, S.(2);Potts Bleakman, A.(3);Kayhan, C.(3);Ellis, H.(4);Hunter Gibble, T.(3);Flynn, E.(3);Suldecki, G.(4);Travis, S.(5);
(1)Icahn School of Medicine, Mount Sinai, New York, United States;(2)University Hospital Schleswig-Holstein, Department of Internal Medicine, Kiel, Germany;(3)Eli Lilly and Company, Eli Lilly and Company, Indianapolis, United States;(4)Adelphi Real World, Bespoke, Bollington, United Kingdom;(5)University of Oxford, Gastroenterology, Oxford, United Kingdom;
P088: Metabolomic analysis reveals differences among UC and non-IBD human colonic resections: role of GPCRsECCO'22Year: 2022
Authors: Bauset, C.(1);Carda-Diéguez, M.(2);Buetas, E.(2);Coll, S.(1);Lis-López, L.(1);Seco-Cervera, M.(3);Navarro, F.(4);Mira, Á.(2);Calatayud, S.(1);Barrachina, M.D.(1);Cosín-Roger, J.(3);
(1)Universidad de Valencia, Pharmacology, Valencia, Spain;(2)FISABIO, Genomics and Health Department, Valencia, Spain;(3)FISABIO, Unidad Mixta Facultad de Medicina-Hospital Dr. Peset, Valencia, Spain;(4)Hospital de Manises, Colorectal surgery, Valencia, Spain;
P089: Long ncRNA Landscape in the Rectum of Treatment Naïve Early Onset Ulcerative Colitis Highlights Association with Severity and Early and Late Disease Outcome, with Potential Role in Epithelial Metabolic FunctionsECCO'22Year: 2022
Authors: Haberman Ziv, Y.(1);Braun, T.(1);Sosnovski , K.(1);Amir , A.(1);VanDussen , K.(2);Igor Ulitsky , I.U.(3);Griffiths , A.(4);Walters , T.(4);Mack , D.(5);Boyle, B.(6);Kugathasan, S.(7);Jegga, A.(8);Hyams , J.(9);Denson, L.(2);
(1)Tel-HaShomer Sheba Medical Center, Department of Pediatric Gastroenterology, Ramat Gan, Israel;(2)Cincinnati Children's Hospital Medical Center, Gastroenterology, Cincinnati, United States;(3)Weizmann Institute of Science, Biology, Rehovot, Israel;(4)Hospital For Sick Children, Pediatrics, Toronto, Canada;(5)Children's Hospital of East Ontario, Pediatrics, Ottawa, Canada;(6)Nationwide Children's Hospital, Pediatrics, Colombus, United States;(7)Emory University, Pediatirics, Atlanata, United States;(8)Cincinnati Children's Hospital Medical Center, Pediatirics, Cincinnati, United States;(9)Connecticut Children’s Medical Center, Pediatrics, Hartford, United States;PROTECT cohort
P090: Unraveling the rewiring of cytokine signalling in Inflammatory Bowel Disease using a novel network biology approachECCO'22Year: 2022
Authors: Olbei, M.(1,2);Thomas, J.(1,2,3);Hautefort, I.(1);Treveil, A.(1,2);Bohar, B.(1,4);Madgwick, M.(1,2);Gul, L.(1);Csabai, L.(1,4);Modos, D.(1,2);Korcsmaros, T.(1,2,5);
(1)Earlham Institute, Organisms and Ecosystems, Norwich, United Kingdom;(2)Quadram Institute BioScience, Gut Microbes and Health, Norwich, United Kingdom;(3)Norfolk and Norwich University Hospital, Department of Gastroenterology, Norwich, United Kingdom;(4)Eotvos Lorand University, Department of Genetics, Budapest, Hungary;(5)Imperial College London, Faculty of Medicine- Department of Metabolism- Digestion and Reproduction, London, United Kingdom;
P091: A single-cell RNAseq approach to understand and predict the efficacy of tofacitinib in Ulcerative ColitisECCO'22Year: 2022
Authors: Melon, E.(1);Corraliza, A.M.(1);Garrido, A.(1);Veny, M.(1);Masamunt, M.C.(1);Giner, A.(1);Ordás, I.(1);Fernández, A.(1);Ricart, E.(1);Panés, J.(1);Salas, A.(1);
(1)Institut d'Investigacions Biomèdiques August Pi i Sunyer IDIBAPS, Hospital Clinic of Barcelona - Inflammatory Bowel Disease Unit, Barcelona, Spain;
P092: Humoral and T cell responses to COVID-19 vaccination in IBDECCO'22Year: 2022
Authors: Zhang, E.(1);Bond, K.(2);Nguyen, O.(3);Allen, L.(3);Kedzierski , L.(3);Kedzierka, K.(3);Christensen, B.(1);
(1)Royal Melbourne Hospital, Gastroenterology, Melbourne, Australia;(2)Royal Melbourne Hospital, Microbiology, Victoria, Australia;(3)University of Melbourne, Microbiology and Immunology, Victoria, Australia;
P093: Probiotic strains Lactobacillus plantarum and Saccharomyces boulardii influence the fibrotic responses of human intestinal subepithelial myofibroblasts.ECCO'22Year: 2022
Authors: Tarapatzi, G.(1);Filidou, E.(1);Kandilogiannakis, L.(1);Spathakis, M.(1);Arvanitidis, K.(1);Kotzampassi , K.(2);Kolios, G.(1);Vradelis, S.(3);
(1)Laboratory of Pharmacology- Faculty of Medicine, Democritus University of Thrace- Alexandroupolis, Alexandroupolis, Greece;(2)Department of Surgery, Aristotle University of Thessaloniki- AHEPA Hospital, Thessaloniki, Greece;(3)University Hospital of Alexandroupolis, Democritus University of Thrace, Alexandroupolis, Greece;
P094: Transcriptomic and small RNA sequencing profile in ileal resections from complicated Crohn´s Disease patientsECCO'22Year: 2022
Authors: Seco-Cervera, M.(1);Bauset, C.(2);Santana-Plata, C.(2);Civera-Barrachina, M.(2);Ortiz-Masià, D.(2);Calatayud, S.(2);Barrachina, M.D.(2);
(1)Hospital Dr Peset- FISABIO, Pharmacology, Valencia, Spain;(2)Faculty of Medicine - University of Valencia, Pharmacology, Valencia, Spain;
P095: Anti-inflammatory effect of high acetate concentration on organoid-derived epithelial monolayer from patients with Ulcerative ColitisECCO'22Year: 2022
Authors: Deleu, S.(1);Arnauts, K.(1,2);Machiels, K.(1);Huys, G.R.B.(3,4);Thevelein, J.(5,6);Raes, J.(3,4);Vermeire, S.(1,7);
(1)KU Leuven, Chrometa Targid, Leuven, Belgium;(2)KU Leuven, Development and Regeneration- Stem Cell Institute Leuven, Leuven, Belgium;(3)KU Leuven, Microbiology and Immunology- Rega Institute, Leuven, Belgium;(4)VIB, Center for Microbiology, Leuven, Belgium;(5)Erasmus High School, NovelYeast bv- Open Bio-Incubator, Brussels, Belgium;(6)KU Leuven, Molecular Cell Biology- Institute of Botany and Microbiology, Leuven, Belgium;(7)University Hospitals Leuven- KU Leuven, Gastroenterology and Hepatology, Leuven, Belgium;MIMOSA
P096: Store-Operated Calcium Entry Controls Innate and Adaptive Immune Cell Function in Inflammatory Bowel DiseaseECCO'22Year: 2022
Authors: Letizia, M.(1);Kaufmann, U.(2);Wang, Y.H.(2);Gerbeth, L.(1);Sand, A.(1);Brunkhorst, M.(1);Böttcher, C.(3);Schlickeiser, S.(4);Fernández-Zapata, C.(3);Kunkel, D.(4);Siegmund, B.(1);Feske, S.(2);Weidinger, C.(1);
(1)Charité Universitätsmedizin Berlin, Medical Department- Division of Gastroenterology- Infectiology and Rheumatology, Berlin, Germany;(2)New York University Grossman School of Medicine, Department of Pathology, New York, United States;(3)Charité and MDC, Experimental and Clinical Research Center, Berlin, Germany;(4)Berlin Institute of Health at Charité - Universitätsmedizin Berlin, Flow & Mass Cytometry Core Facility, Berlin, Germany;IBDome researchers TRR 241 Research Initiative
P099: Serum proteomic analysis reveals novel biomarkers associated with disease activity in pediatric patients with Crohn’s diseaseECCO'22Year: 2022
Authors: Werner, L.(1);Weiss, B.(2);Matar, M.(1);Shamir, R.(1);Shouval, D.(1);
(1)Schneider Children's Medical Center of Israel, Institute of Gastroenterology- Nutrition and Liver Diseases, Petah Tiqwa, Israel;(2)Edmond and Lliy Safra Children's Hospital, Pediatric Gastroenterology Unit, Ramat Gan, Israel;
P100: Serum inflammatory protein profiling to corroborate selection of therapy naïve moderate-to-severe pediatric Crohn’s disease patients eligible for first-line infliximab treatmentECCO'22Year: 2022
Authors: Jongsma , M.M.E.(1);Costes , L.M.M.(2);Tindemans , I.(2);Cozijnsen , M.A.(1);Raatgreep , R.H.C.(2);van Pieterson , M.(1);Li , Y.(3);Escher , J.C.(1);de Ridder , L.(1);Samsom , J.N.(2);
(1)Erasmus University Medical Center/Sophia Children's Hospital, Department of Pediatric Gastroenterology, Rotterdam, The Netherlands;(2)Erasmus University Medical Center, Laboratory of Paediatrics- Division of Gastroenterology and Nutrition, Rotterdam, The Netherlands;(3)Erasmus University Medical Center- Erasmus MC Cancer Institute, Department of Pathology & Clinical Bioinformatics, Rotterdam, The Netherlands;
P102: Changes in serum immune protein profiles following vedolizumab therapy in Inflammatory Bowel Disease.ECCO'22Year: 2022
Authors: O'Connell, J.(1,2);O'Connell, F.(2);O'Sullivan, J.(2);Kevans, D.(1,2,3);
(1)St James's Hospital, Gastroenterology, Dublin, Ireland;(2)Dublin University- Trinity College, Trinity Translational Medicine Institute, Dublin, Ireland;(3)Dublin University- Trinity College, School of Medicine, Dublin, Ireland;
P103: Identifying CES-1 positive myeloid cells with mass cytometry as a potential therapeutic target for Crohn’s diseaseECCO'22Year: 2022
Authors: HagemanMD, I.(1);Elfiky, A.(2);Becker, M.(2);Joustra, V.(1);Buskens, C.(3);Li Yim, A.(2);Hakvoort, T.(2);Verhoeff, J.(4);Garcia Vallejo, J.(4);D'Haens, G.(1);Wildenberg, M.(2);De Jonge, W.(2);
(1)Academic Medical Center AMC University of Amsterdam, Department of Gastroenterology & Hepatology, Amsterdam, The Netherlands;(2)Academic Medical Center AMC University of Amsterdam, Tytgat Institute for Liver and Intestinal Research, Amsterdam, The Netherlands;(3)Academic Medical Center AMC University of Amsterdam, Department of Surgery, Amsterdam, The Netherlands;(4)Academic Medical Center AMC University of Amsterdam, Department of Molecular Cell Biology & Immunology- Amsterdam Infection & Immunity Institute and Cancer Center Amsterdam, Amsterdam, The Netherlands;
