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P097 Depletion of delta-like ligand 4 (Dll4) contributes to the alteration of secretory progenitor differentiation in SAMP1/YitFc mice with Crohn’s disease-like ileitis

ECCO'20 Vienna

Year: 2020
Authors:

S.N. Hong1, J.H. Song2, G. Seong1, S.M. Kong1, J.B. Shin1, K. Eun Ran1, C. Dong Kyung1, K. Young-Ho1

1Samsung Medical Center, Department of Gastroenterology, Seoul, Republic of Korea, 2Samsung Medical Center, Gastroenterology, Seoul, Republic of Korea

P098 Receptor-interacting protein 1 kinase inhibition therapeutically ameliorates experimental T-cell-dependent colitis in mice

ECCO'20 Vienna

Year: 2020
Authors:

T. Gobbetti1, F. Kathryn1, A. Beal2, A. Rowles3, G. Pearse4, I. Harada5, J. Bertin2, A. Haynes1, S. Berger2

1GSK, Adaptive Immunity Research Unit, Stevenage, UK, 2GSK, Innate Immunity Research Unit, Philadelphia, USA, 3GSK, In Vitro/In Vivo Translation, Ware, UK, 4GSK, 3In Vitro/In Vivo Translation, Ware, UK, 5GSK, Dmpk, Stevenage, UK

P099 Neutrophil gelatinase-associated lipocalin (NGAL) as biomarker in collagenous colitis

ECCO'20 Vienna

Year: 2020
Authors:

G.A. Walaas1, I. Bakke1,2, A.V. Granlund1,3, C. Escuderos-Hernândez4, T. Bruland1,2, E.S. Røyset1,5, S. Thorsvik2,6, A. Münch4,7, A.E. Østvik1,2,6, A.K. Sandvik1,2,3,6

1Norwegian University of Science and Technology, Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Trondheim, Norway, 2St. Olav’s University Hospital, Clinic of Medicine, Trondheim, Norway, 3Norwegian University of Science and Technology, Centre of Molecular Inflammation Research, NTNU, Trondheim, Norway, 4Linköping University, Department of Biomedical and Clinical Sciences BVK, Linköping, Sweden, 5St. Olav’s University Hospital, Department of Pathology, Clinic of Laboratory Medicine, Trondheim, Norway, 6St. Olav’s University Hospital, Department of Gastroenterology, Clinic of Medicine-, Trondheim, Norway, 7Linköping University Hospital, Department of Gastroenterology and Hepatology, Linköping, Sweden

P100 CD161 levels are reduced in all subpopulations of T-cell colonic mucosal lymphocytes in inflammatory bowel disease

ECCO'20 Vienna

Year: 2020
Authors:

E. Tristan, A. Carrasco, A. Martín-Cardona, Y. Zabana, M. Aceituno, A. Raga, X. Andújar, B. Arau, P. Ruiz-Ramírez, L. Ruiz-Campos, F. Fernández-Bañares, M. Esteve

Gastroenterology Department, Hospital Universitari Mútua Terrassa, Universitat de Barcelona, Terrassa. Centro de Investigación Biomédica en red de enfermedades hepáticas y digestivas CIBERehd, Gastroenterology Department, Terrassa, Spain

P101 Biomarkers of elastin degradation are associated with clinical and biochemically active disease in Crohn’s disease

ECCO'20 Vienna

Year: 2020
Authors:

M. Pehrsson1, V. Domislović2, M.A. Karsdal1, M. Brinar2, A. Barisic3, Z. Krznaric2, T. Manon-Jensen1, J.H. Mortensen1

1Nordic Bioscience A/S, Biomarkers and Research, Herlev, Denmark, 2University Hospital Centre Zagreb, Department of Gastroenterology and Hepatology, Zagreb, Croatia, 3University Hospital Centre Zagreb, Department for Clinical Nutrition, Zagreb, Croatia

P102 Host gene background and concentration influence the butyrate effect on modulating IECs proliferation

ECCO'20 Vienna

Year: 2020
Authors:

H. He1, J. Hu2, W. Wang2, M. Zhang2, M. Zheng2, X. Peng2, Y. Zhang2, M. Zhou2, T. Liu2, J. Zhao2, Q. Zhang2, M. Zhi2,1

1The Second Affiliated Hospital of South China University of Technology, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou First People’s Hospital, Guangdong Institute of Gastroenterology, Guangdong Province Key Laboratory of Colorectal and Pelvic Floor Diseases, Gastroenterology, Guangzhou, China, 2The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangdong Institute of Gastroenterology- Guangdong Province Key Laboratory of Colorectal and Pelvic Floor Diseases, Gastroenterology, Guangzhou, China

P103 The treatment effect of tonsil-derived mesenchymal stem cells (T-MSCs) via regulating programmed death-1/programmed death ligand-1 (PD-1/PD-L1) in ulcerative colitis

ECCO'20 Vienna

Year: 2020
Authors:

E.M. Song, Y.H. Joo, J.Y. Lim, A.R. Choe, C.H. Tae, C.M. Moon, S.E. Kim, H.K. Jung, K.N. Shim, S.A. Jung

Department of Gastroenterology, Ewha Womans University College of Medicine, Seoul, Republic of Korea

P104 Defective metabolism mediates NK cell dysfunction in inflammatory bowel disease (IBD)

ECCO'20 Vienna

Year: 2020
Authors:

V. Zaiatz Bittencourt1, E. Ryan2, F. Jones1, G. Doherty1

1School of Medicine, University College Dublin, Dublin, Ireland, 2Department of Biological Sciences, University of Limerick, Dublin, Ireland

P105 Glutathione S-transferase theta 1 protects against colitis through goblet cell differentiation via interleukin-22

ECCO'20 Vienna

Year: 2020
Authors:

J.H. Kim1, J.B. Ahn2, D.H. Kim1, S. Kim3, H.W. Ma1, X. Che1, D.H. Seo1, T.I. Kim1, W.H. Kim3, J.H. Cheon1, S.W. KimResearch Professor1

1Yonsei University College of Medicine, Brain Korea 21 PLUS Project for Medical Science, Seoul, Republic of Korea, 2Yonsei University College of Medicine, Department of Medicine, Seoul, Republic of Korea, 3Yonsei University College of Medicine, Department of Internal Medicine and Institute of Gastroenterology, Seoul, Republic of Korea

P106 Depressive symptoms and anxiety and their screening in IBD patients: performance of the distress thermometer in Italian IBD patients

ECCO'20 Vienna

Year: 2020
Authors:

C. Canaletti1, F. Colombo2, A. Dessì2, E. Geccherle3, A. Tongiorgi4, P. Cai5, F. Giudici6, G. Mocci7, F.M. Onidi7, A. Orlando8, M.G. Mortillaro8, F. Bossa9, G. Martino9, M. Placentino9, L. Guidi10, D. Pugliese10, L. Tiberio10, F. Costa4, G. Deledda3, A. Geccherle3, A. Paolini1, C.F. Tonello1, G.M. Pecoraro1, F. Monica1

1Asuits Cattinara Hospital, Gastroenterology, Trieste, Italy, 2Istituto Milanese di Psicoterapia Cognitivo Comportamentale - IMIPSI, Psychology, Milano, Italy, 3Ospedale IRCCS ‘Sacro Cuore - Don Calabria’ Istituto di Ricovero e Cura a Carattere Scientifico Ospedale Classificato e Presidio Ospedaliero Accreditato - Regione Veneto, Gastroenterology, Verona, Italy, 4Azienda Ospedaliero Universitaria di Pisa – AOUP, Gastroenterology, Pisa, Italy, 5Ospedale San Martino, Genova, Psychology, Genova, Italy, 6Unit of Biostatistics, Epidemiology and Public Health, Department of Cardiac, Thoracic, VascularSciences and Public Health, University of Padova, Biostatistics, Padova, Italy, 7Ospedale S. Michele Brotzu, Gastroenterology, Cagliari, Italy, 8Ospedali Riuniti Villa Sofia-Cervello, Internal Medicine, Palermo, Italy, 9Ospedale Regionale Casa Sollievo della Sofferenza IRCCS di San Giovanni Rotondo, Gastroenterology, San Giovanni Rotondo, Italy, 10IBD Unit Presidio Columbus-Fondazione Policlinico Universitario A. Gemelli IRCCS e Università Cattolica del Sacro Cuore, Gastroenterology, Roma, Italy

P107 The expression and regulation of Oncostatin M and its receptor in intestinal inflammation

ECCO'20 Vienna

Year: 2020
Authors:

R. Cineus1,2, D. Boesel1,2, S. Hainbuch1,2, C. Jukes1,2, Y.H. Hsieh1,2, J. Reich1,2, Z. Borek1,2, A. Kuehl1,3, A.N. Hegazy PhD, MD1,2

1IBDome-DE Investigators, Charité – University Medicine Berlin, CBF and German Rheumatism Research Center-Berlin, Department of Gastroenterology, Infectiology and Rheumatology, Berlin, Germany, 2Deutsches Rheuma-Forschungszentrum, ein Institut der Leibniz-Gemeinschaft, Inflammatory Mechanisms Group, Berlin, Germany, 3Charité-Universitätsmedizin Berlin, iPath.Berlin-Immunopathology for Experimental Models, Berlin, Germany

P108 The importance of developing consensus-driven clinical data standards for Crohn’s disease to amplify data

ECCO'20 Vienna

Year: 2020
Authors:

J. Owen, R. Baker

CDISC, Standards Development, Austin, USA

P109 Construction of a suite of computable biological network models focused on inflammatory bowel disease

ECCO'20 Vienna

Year: 2020
Authors:

P.A. Ruiz Castro, H. Yepiskoposyan, J. Szostak, M. Talikka, J. Hoeng

PMI, Systems toxicology, Neuchatel, Switzerland

P110 Identification of the tryptophan metabolite 3-hydroxyanthranilic acid as a novel tool for the differentiation of Crohn’s disease phenotypes

ECCO'20 Vienna

Year: 2020
Authors:

M. Huhn1, M. Herrero San Juan1, B. Melcher2, C. Dreis1, K. Schmidt1, J.M. Pfeilschifter1, M. Vieth2, J. Stein3, H.H. Radeke1

1Pharmazentrum Frankfurt, Institute of Pharmacology and Toxicology, Frankfurt am Main, Germany, 2Institute of Pathology, Klinikum Bayreuth, Bayreuth, Germany, 3Department of Gastroenterology and Clinical Nutrition, DGD Clinics Sachsenhausen, Frankfurt am Main, Germany

P111 Elucidation of inflammatory infiltration of myenteric plexus in IBD

ECCO'20 Vienna

Year: 2020
Authors:

J.J. Wiese, A. Fascì, A.A. Kühl, B. Siegmund, M.S. Prüß, M. Schumann

Department of Gastroenterology, Infectious Diseases and Rheumatology, Campus Benjamin Franklin, Charité – Universitätsmedizin Berlin, Berlin, Germany

P112 Body composition and resting energy expenditure in IBD patients receiving biological therapy

ECCO'20 Vienna

Year: 2020
Authors:

D. Vranesic Bender1, L. Cengic2, D. Ljubas Kelecic1, I. Karas1, A. Grbin Hodžić3, V. Domislović3, M. Brinar3, M. Juričić1, Ž. Krznarić3

1University Hospital Zagreb, Unit of Clinical Nutrition, Zagreb, Croatia, 2Faculty of Food Technology and Biotechnology, Laboratory of Nutrition Science, Zagreb, Croatia, 3Department of Gastroenterology and Hepatology, University Hospital Zagreb, Zagreb, Croatia

P113 Serum adipokines as non-invasive biomarker in Crohn’s disease

ECCO'20 Vienna

Year: 2020
Authors:

L. Ortega Moreno1, A. Sanz-Garcia2, M.J. Fernández de la Fuente3, R. Arroyo Solera4, M. Chaparro5, S. Fernandez-Tome6, A.C. Marin7, I. Mora-Fernandez6, P. Fernandez4, M. Baldan-Martin7, D. Bernardo8,9, J.P. Gisbert5,9

1Universidad Autónoma de Madrid. Hospital Universitario de La Princesa, Medicina, Madrid, Spain, 2Unidad de Análisis de Datos. Hospital Universitario de La Princesa, Análisis de Datos, Madrid, Spain, 3Universidad de Alcalá., Farmacia, Alcalá de Henares Madrid, Spain, 4Instituto de Medicina Molecular Aplicada IMMA. Universidad San Pablo CEU., Medicina, Madrid, Spain, 5Universidad Autónoma de Madrid. Hospital Universitario de La Princesa. CIBERehd., Medicina, Madrid, Spain, 6Hospital Universitario de La Princesa, Medicina, Madrid, Spain, 7Hospital Universitario de La Princesa. CIBERehd., Medicina, Madrid, Spain, 8Mucosal Immunolgy lab. Instituto de de Biología y Genética Molecular IBGM., Medicina, Valladolid, Spain, 9Both authors had equal contribution- as senior authors, Medicina, Madrid, Spain

P114 A screening tool for the early diagnosis of extraintestinal manifestations in inflammatory bowel disease: the EMAIL questionnaire

ECCO'20 Vienna

Year: 2020
Authors:

A. Busacca, G. Ingrassia Strano, E. Giuffrida, L. Guida, B. Scrivo, L. Carrozza, V. Calvaruso, M. Cappello

Gastroenterology and Hepatology Section, University of Palermo, PROMISE, Palermo, Italy

P115 Real-world experience of peri-operative treatments on surgical complications after Ileo-caecal resection in Crohn’s disease

ECCO'20 Vienna

Year: 2020
Authors:

S. Di Stefano1,2, C. Liefferinckx3, A. Cremer3, L. Amininejad3, A. Van Gossum3, J. Devière3, J. Van de Stadt4, D. Franchimont3, A. Buggenhout4

1Hôpital Erasme, Department of Gastroenterelogy, Brussels, Belgium, 2The Pancreas Institute. University of Verona. G.B. Rossi University, Gastroenterology and Digestive Endoscopy Unit, Verona, Italy, 3Hôpital Erasme, Gastroenterelogy, Brussels, Belgium, 4Hôpital Erasme, Clinic of Colorectal Surgery – Department of Digestive Surgery, Brussels, Belgium

P116 The occurrence of venous thromboembolisms in paediatric-onset IBD

ECCO'20 Vienna

Year: 2020
Authors:

M. Aardoom1, P. Kemos2, F.M. Ruemmele3, C.H. van Ommen4, N.M. Croft2, L. de Ridder1, On Behalf of the PIBD-SETQuality Consortium and PIBDnet

1Erasmus MC/Sophia Children’s Hospital, Department of Paediatric Gastroenterology, Rotterdam, The Netherlands, 2Centre for Immunobiology, Blizard Institute, Barts and the London School of Medicine, Queen Mary University of London, Department of Paediatric Gastroenterology, London, UK, 3Université Paris Descartes, Sorbonne Paris Cité, APHP, Hôpital Necker Enfants Malades, Department of Pediatric Gastroenterology, Paris, France, 4Erasmus Medical Center, Sophia Children’s Hospital, Department of Pediatric Hematology, Rotterdam, The Netherlands