P633: First-in-Human Pharmacokinetic and Safety Study of an Anti-TL1A Antibody, TEV-48574, in Healthy Volunteers and Asthma PatientsECCO'24Year: 2024
Authors: Balyan, R.(1)*;Ghibellini, G.(1);Sunzel, E.M.(1);Dreymann, J.(2);Radivojevic, A.(3);Dotan, O.(2);Angeles, T.(1);Li, S.(1);Papp, A.(4);Rasamoelisolo, M.(1);Rabinovich-Guilatt, L.(2);
(1)Teva Branded Pharmaceutical Products, Research and Development, West Chester PA, United States;(2)Teva Pharmaceutical Industries Ltd.-, Research and Development, Netanya, Israel;(3)intiGROWTH, Llc, Miami FL, United States;(4)Teva Pharmaceutical Industries Ltd.-, Research and Development, Debrecen, Hungary;
P634: Durability of a second-line anti-TNFɑ agent compared to a different mechanism of action after first anti-TNFɑ failure in ulcerative colitis: CambiaCU StudyECCO'24Year: 2024
Authors: López-Vico, M.(1)*;Hernández-Martínez, Á.(2);Soto-Escribano, P.(3);Rojas-Feria, M.(4);Cornejo-Jiménez, A.(4);Caballero-Mateos, A.M.(5);Trapero-Martínez, A.M.(6);Sánchez-Capilla, A.D.(7);Cabello-Tapia, M.J.(7);Martín-Rodríguez, M.D.M.(7);
(1)Virgen de las Nieves University Hospital, Gastroenterology and Hepatology, Granada, Spain;(2)Hospital Universitario Torrecárdenas, Gastroenterology Unit, Almería, Spain;(3)Hospital Universitario Reina Sofía, Gastroenterology Unit, Córdoba, Spain;(4)Hospital Universitario Virgen del Rocío, Gastroenterology Unit, Sevilla, Spain;(5)Hospital Santa Ana de Motril, Gastroenterology Unit, Motril, Spain;(6)Hospital Universitario de Jaén, Gastroenterology Unit, Jaén, Spain;(7)Hospital Universitario Virgen de la Nieves, Gastroenterology Unit, Granada, Spain;
P635: Intravenous albumin infusion does not augment the response rate to a combination of exclusive enteral nutrition and intravenous steroids in Acute Severe Ulcerative Colitis: a randomized controlled trialECCO'24Year: 2024
Authors: Mundhra, S.(1)*;Madan, D.(1);Golla, R.(1);Sahu, P.(1);K Vuyyuru, S.(1);Kante, B.(1);Kumar, P.(1);Matthew, D.(1);Prasad, S.(1);Vaishnav, M.(1);Verma, M.(1);Virmani, S.(1);Bajaj, A.(1);Markandey, M.(1);Kumar Ranjan, M.(1);Arora, U.(1);Kumar Singh, M.(1);K Makharia, G.(1);Kedia, S.(1);Ahuja, V.(1);
(1)All India Institute of Medical Sciences- New Delhi, Gastroenterology, New Delhi, India;
P636: Comparison of the real-world efficacy of filgotinib with tofacitinib in patients with refractory ulcerative colitis: A single-center retrospective studyECCO'24Year: 2024
Authors: Yagi, S.(1)*;Fukui, H.(1);Yokoyama, K.(1);Kaku, K.(1);Takagi, Y.(1);Ikenouchi, M.(1);Sato, T.(1);Kawai, M.(1);Kamikozuru, K.(1);Yokoyama, Y.(1);Tomita, T.(1);Shinzaki, S.(1);
(1)Hyogo Medical University, Department of Gastroenterology- Faculty of Medicine, Nishinomiya, Japan;
P637: Ozanimod efficacy with or without concomitant corticosteroids in 5-ASA–exposed, advanced therapy–naive, immunomodulator-naive patients with ulcerative colitis: a post hoc analysis of True NorthECCO'24Year: 2024
Authors: Horst, S.(1)*;Fischer, M.(2);Kinnucan, J.A.(3);Sauk, J.S.(4);Wu, H.(5);Jain, A.(5);Ahmad, H.A.(5);Osterman, M.T.(5);Rosen, M.(5);Sands, B.E.(6);
(1)Vanderbilt University Medical Center, Gastroenterology- Hepatology- and Nutrition, Nashville, United States;(2)Indiana University School of Medicine, Gastroenterology and Hepatology, Indiana, United States;(3)Mayo Clinic, Gastroenterology and Hepatology, Jacksonville, United States;(4)UCLA Center for Inflammatory Bowel Diseases, Gastroenterology, Los Angeles, United States;(5)Bristol Myers Squibb, n/a, Princeton, United States;(6)Icahn School of Medicine at Mount Sinai, Gastroenterology, New York, United States;
P638: Efficacy of Induction upadacitinib Therapy in Chinese Patients with Moderately to Severely Active Crohn’s DiseaseECCO'24Year: 2024
Authors: Chen, M.(1)*;Gao, X.(2);Cao, Q.(3);Zhang, X.(4);Chen, Y.(5);Hou, X.(6);Zhong, J.(7);Sun, Y.(8);Phaleng, X.(9);
(1)The First Affiliated Hospital- Sun Yat-sen University, Division of Gastroenterology, Guangzhou, China;(2)The Sixth Affiliated Hospital- Sun Yat-sen University, Division of Gastroenterology, Guangzhou, China;(3)Sir Run Run Shaw Hospital- Medical School Zhejiang University, Division of Gastroenterology, Hangzhou, China;(4)Nanjing Drum Tower Hospital, Division of Gastroenterology, Nanjing, China;(5)The second Affiliated Hospital of Zhejiang University, Division of Gastroenterology, Hangzhou, China;(6)Union Hospital Tongji Medical College Huazhong University, Division of Gastroenterology, Wuhan, China;(7)Ruijin Hospital- Shanghai Jiaotong University School of Medicine, Division of Gastroenterology, Shanghai, China;(8)Abbvie, Medical Affairs, Shanghai, China;(9)Abbvie, Medical Affairs, Gauteng, South Africa;
P639: Tofacitinib induces clinical remission in patients with chronic pouchitisECCO'24Year: 2024
Authors: de Jong, D.C.(1)*;Goetgebuer, R.(1);Müskens, B.(1);Neefjes-Borst, A.(2);Gecse, K.(1);Löwenberg, M.(1);de Jonge, W.(3);Bemelman, W.(4);Ponsioen, C.(1);D@E@Haens, G.(1);Duijvestein, M.(5);
(1)Amsterdam UMC, Department of Gastroenterology and Hepatology, Amsterdam, The Netherlands;(2)Amsterdam UMC, Department of Pathology, Amsterdam, The Netherlands;(3)Tytgat Institute for Liver and Intestinal Research, Gastroenterology and Hepatology, Amsterdam, The Netherlands;(4)Amsterdam UMC, Department of Surgery, Amsterdam, The Netherlands;(5)Radboudumc, Department of Gastroenterology and Hepatology, Nijmegen, The Netherlands;
P640: Role of vedolizumab trough levels in predicting clinical response in Inflammatory Bowel Disease: a multicentre prospective studyECCO'24Year: 2024
Authors: Falzone, M.H.(1)*;Ribaldone, D.G.(1);Saracco, G.M.(1);Bertani, L.(2);Ceccarelli, L.(2);Costa, F.(2);Bottari, A.(3);Fornaroli, G.(3);Cusato, J.(4);D@E@Avolio, A.(4);Palermiti, A.(4);Antonucci, M.(4);
(1)University of Turin, Department of Medical Sciences, Turin, Italy;(2)University Hospital of Pisa, Department of General Surgery and Gastroenterology, Pisa, Italy;(3)University of Pisa, Gastroenterology Unit, Pisa, Italy;(4)University of Turin, Laboratory of Clinical Pharmacology and Pharmacogenetics- Department of Medical Sciences, Turin, Italy;
P641: Faecal calprotectin determines non-response to corticosteroids in patients with immune checkpoint inhibitor colitisECCO'24Year: 2024
Authors: Crothers-Stomps, L.(1);Kuo, H.(2)*;Teh, W.X.(2);White, L.(2);Mohsen, W.(1);Kakkadasam Ramaswany, P.(1);Mason, R.(3);Dzienis, M.(3);Patrick, D.(2);
(1)Gold Coast University Hospital, Gastroenterology, Gold Coast, Australia;(2)Sunshine Coast University Hospital, Gastroenterology, Sunshine Coast, Australia;(3)Gold Coast University Hospital, Oncology, Gold Coast, Australia;
P642: Effect of prior vedolizumab treatment on ustekinumab time-on-treatment in Crohn’s disease: a targeted literature review and statistical analysesECCO'24Year: 2024
Authors: Owen, G.(1)*;Harvey, R.(2);Shields, G.(3);Jenkins, A.(4);Robertson, J.(5);Eaton, J.(4);
(1)Takeda UK Ltd., Market Access, High Wycombe, United Kingdom;(2)Cabourn Statistics, Statistician, Sheffield, United Kingdom;(3)cabourn Statistics, Health Economist, Sheffield, United Kingdom;(4)Takeda UK Ltd, Market Access, London, United Kingdom;(5)Takeda UK Ltd, Medical, London, United Kingdom;
P643: Magnifying Endoscopy with Narrow Band Imaging for Graft Failure and Disease Recurrence in Patients with Crohn’s Disease after Intestinal TransplantationECCO'24Year: 2024
Authors: Chung, C.S.(1)*;Lee, T.H.(2);Tsai, C.C.(3);Yu, C.H.(2);Chen, Y.(4);
(1)Far Eastern Memorial Hospital, Division of Gastroenterology and Hepatology- Department of Internal Medicine, New Taipei City, Taiwan;(2)Far Eastern Memorial Hospital, Department of Internal Medicine, New Taipei City, Taiwan;(3)Far Eastern Memorial Hospital, Department of Anatomical Pathology, New Taipei City, Taiwan;(4)Far Eastern Memorial Hospital, Department of Surgery, New Taipei City, Taiwan;
P644: Body composition does not predict clinical course in patients with acute severe ulcerative colitisECCO'24Year: 2024
Authors: Tassone, D.(1)*;Xu, E.(2);Winata, S.H.L.(2);Hale, P.(2);Basnayake, C.(1,3);Schulberg, J.(1,3);Flanagan, E.(1,3);Wright, E.(1,3);Kamm, M.A.(1,3);Lust, M.(1);Niewiadomski, O.(1);Tambakis, G.(1);Clark, N.(1);Hartley, I.(1,3);De Gregorio, M.(1,3);Sutherland, T.(2,3);Thompson, A.J.(1,3);Connell, W.R.(1,3);Ding , N.S.(1,3);
(1)St Vincent@E@s Hospital Melbourne, Department of Gastroenterology, Fitzroy, Australia;(2)St Vincent@E@s Hospital Melbourne, Department of Medical Imaging, Fitzroy, Australia;(3)The University of Melbourne, Department of Medicine, Parkville, Australia;
P646: Clinical decision support in the prevention of adverse effects associated with immunosuppressive drugs in patients with Inflammatory Bowel DiseaseECCO'24Year: 2024
Authors: Lobato Matilla, M.E.(1)*;Marin Jimenez, I.(2);Menchén Viso, L.A.(2);Miranda Bautista, J.(2);Chamorro de Vega, E.(1);Romero Jiménez, R.(1);Ferris Villanueva, M.(1);Herranz Alonso, A.(1);Sanjurjo Sáez, M.(1);
(1)H.G.U. Gregorio Marañon, Pharmacy Department, Madrid, Spain;(2)H.G.U. Gregorio Marañon, Gastroenterology, Madrid, Spain;
P647: Effectiveness of combined treatment with two biologics or advanced molecules in inflammatory bowel diseaseECCO'24Year: 2024
Authors: Melcarne, L.(1)*;Laucirica, I.(1);Brunet, E.(1,2);Villoria, A.(1,2,3);Puy, A.(1);Llovet, L.(1);Garcia-Sagué, B.(1);Frisancho, L.E.(1);Altadill, A.(1);López-Sáez, B.(1);Del Estal, J.(4);Calvet, X.(1,2,3);
(1)Parc Taulí Hospital Universitari - Institut d’Investigació i Innovació Parc Taulí I3PT-CERCA, Digestive Disease, Sabadell, Spain;(2)Instituto de Salud Carlos III, CIBERehd, Madrid, Spain;(3)Universitat Autònoma de Barcelona, Medicine, Sabadell, Spain;(4)Parc Taulí Hospital Universitari - Institut d’Investigació i Innovació Parc Taulí I3PT-CERCA, Pharmacy, Sabadell, Spain;
P648: Dietary therapy using a short course of Exclusive Enteral Nutrition followed by the Crohn’s Disease Exclusion Diet in children with mild to severe Crohn’s Disease; maintenance update on the DIETOMICS trialECCO'24Year: 2024
Authors: Sigall-Boneh, R.(1,2)*;Manuel Navas-López, V.(3); Hussey, S.(4);Pujol Muncunill, G.(5);Lawrence, S.(6);Jonsson Rolandsdotter, H.(7,8);Otley, A.(9); Martín-de-Carpi, J.(10);Abramas, L.(11); Herrador López , M.(12);Egea Castillo, N.(13); Chen, M.(14);Hurley, M.(15); Wingate, K.(16);Olen, O.(17,18);Yaakov, M.(19);Wierdsma , N.(20);Van Limbergen, J.(21,22);Wine, E.(23);
(1)Edith Wolfson Medical Center, PIBD Research Center- Pediatric Gastroenterology and Nutrition Unit, Holon, Israel;(2)Tytgat Institute for Liver and Intestinal Research- Academic Medical Center- University of Amsterdam-, Amsterdam Gastroenterology Endocrinology and Metabolism, Amsterdam, The Netherlands;(3)Hospital Regional Universitario de Málaga- ., Paediatric Gastroenterology and Nutrition Unit- IBIMA, Málaga, Spain;(4)Royal College of Surgeons of Ireland and University College Dublin, National Children@E@s Research Centre, Dublin, Ireland;(5)Hospital Sant Joan de Déu, Paediatric Gastroenterology- Hepatology and Nutrition Department., Barcelona, Spain;(6)BC Children@E@s Hospital- University of British Columbia-, Pediatric Fastroenterology, Vancouver- BC, Canada;(7)Södersjukhuset- Karolinska Institutet- 11883, Department of Clinical Science and Education, Stockholm-, Sweden;(8)Sachs@E@ Children and Youth Hospital- Södersjukhuset- 11883, Department of Gastroenterology, Stockholm, Sweden;(9)IWK Health Center-, Division of Gastroenterology and Nutrition, Halifax- NS B3K 6R8-, Canada;(10)Hospital Sant Joan de Déu-, Paediatric Gastroenterology- Hepatology and Nutrition Department, Barcelona, Spain;(11)The E. Wolfson Medical Cente, Paediatric Gastroenterology and Nutrition Unit, Holon, Israel;(12)Hospital Regional Universitario de Málaga, Paediatric Gastroenterology and Nutrition Unit- IBIMA-, Málaga- Spain., Spain;(13)Hospital Sant Joan de Déu, Paediatric Gastroenterology- Hepatology and Nutrition Department, Barcelona, Spain;(14)University of Alberta, Departments of Paediatrics and Physiology-, Edmonton- AB T6G 2R3, Canada;(15)hildren’s Health Ireland - Crumlin, Nutrition, Dublin, Ireland;(16)BC Children@E@s Hospital- University of British Columbia-, Nutirion, Vancouver- BC, Canada;(17)Sachs@E@ Children and Youth Hospital- Södersjukhuset-, Department of Gastroenterology, Stockholm, Sweden;(18)Karolinska Institutet, 12. Clinical Epidemiology Division- Department of Medicine Solna, Stockholm, Sweden;(19)The E. Wolfson Medical Center, Pediatric Gastroenterology and Nutrition Unit, Holon, Israel;(20)Amsterdam University Medical Centers, Division of Nutrition and Dietetics, Amsterdam, The Netherlands;(21)Tytgat Institute for Liver and Intestinal Research- - University of Amsterdam-, Amsterdam Gastroenterology Endocrinology and Metabolism- Academic Medical Center, Amsterdam, The Netherlands;(22)Department of Pediatrics- Amsterdam University Medical Centers- Emma Children’s Hospital-, Division of Paediatric Gastroenterology and Nutrition-, Amsterdam, The Netherlands;(23)University of Alberta, Division of Pediatric Gastroenterology- Department of Pediatrics-, Edmonton- AB, Canada;
P649: Long-term follow-up of the PROTDILAT study; LONG-PROTDILAT Prospective multicenter randomized comparative study of endoscopic treatment of strictures in Crohn@E@s disease (CD): self-expandable metal stent (SEMS) vs endoscopic balloon dilatation (EBD).ECCO'24Year: 2024
Authors: Ruiz Ramírez, P.(1,2)*;Loras, C.(1,2);Gornals, J.(3);Maia Bosca-Watts, M.(4);Brunet, E.(5);Iglesias , E.(6);Barrio , J.(7);Sicilia, B.(8);Dueñas, C.(9);Foruny , J.R.(10);Martín-Arranz , M.D.(11);Busquets, D.(12);Cerrillo, E.(13);García Morales, N.(14);Monfort, D.(15);Pérez-Roldán , F.(16);Pijoan , E.(17);González , B.(18);Reyes , J.(19);Torres , G.(20);Maristany , E.(3);Sanchiz , V.(4);Guardiola , J.(21);Esteve , M.(2,22);
(1)Hospital Universitari Mútua Terrassa, Gastroenterology department. Endoscopy Unit, Terrassa, Spain;(2)Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, CIBERehd, Madrid, Spain;(3)Hospital Universitari de Bellvitge, Gastroenterology Department. Endoscopy Unit, Barcelona, Spain;(4)Hospital Clínico Universitario de Valencia, Gastroenterology department, Valencia, Spain;(5)Hospital Universitari Parc Taulí, Gastroenterology department, Sabadell, Spain;(6)Hospital Universitario Reina Sofía, Gastroenterology department, Córdoba, Spain;(7)Hospital Universitario Rio Hortega, Gastroenterology department, Valladolid, Spain;(8)Complejo Asistencial Universitario de Burgos, Gastroenterology department, Burgos, Spain;(9)Hospital San Pedro de Alcántara, Gastroenterology department, Cáceres, Spain;(10)Hospital Universitario Ramón y Cajal, Gastroenterology department, Madrid, Spain;(11)Hospital Universitario La Paz, Gastroenterology department, Madrid, Spain;(12)Hospital Universitari Dr Josep Trueta, Gastroenterology department, Girona, Spain;(13)Hospital Universitario y Politécnico La Fe, Gastroenterology department, Valencia, Spain;(14)Xerencia Xestion Integrada de Vigo- SERGAS, Gastroenterology department, Vigo, Spain;(15)Consorci Sanitari de Terrassa, Gastroenterology department, Terrassa, Spain;(16)Hospital General La Mancha Centro, Gastroenterology department, Ciudad Real, Spain;(17)Clínica Girona, Gastroenterology department, Girona, Spain;(18)Hospital Clínic i Provincial de Barcelona, Gastroenterology department, Barcelona, Spain;(19)Hospital Comarcal d@E@Inca, Gastroenterology department, Inca, Spain;(20)Hospital Universitari Arnau de Vilanova, Gastroenterology department, Lleida, Spain;(21)Hospital Universitari de Bellvitge, Gastroenterology department, Barcelona, Spain;(22)Hospital Universitari Mútua Terrassa, Gastroenterology department, Terrassa, Spain;
P650: Optimization through iv maintenance with ustekinumab in Inflammatory Bowel Disease. Efficacy and adjusted regimen in real world.ECCO'24Year: 2024
Authors: Mínguez, A.(1)*;Coello, E.(1);Gomez, M.(2);Ripoll, P.(1);Garrido, A.(1);Aguas, M.(1);Iborra, M.(1);Cerrillo, E.(1);Tortosa, L.(3);Bayarri, V.(3);Nos, P.(1);Bastida, G.(1);
(1)La Fe University and Polytechnic Hospital, Gastroenterology Department, Valencia, Spain;(2)Complexo Hospitalario Universitario de A Coruña, Department of Gastroenterology, A Coruña, Spain;(3)La Fe University and Polytechnic Hospital, IIS Hospital la Fe. IBD research group, Valencia, Spain;
P651: A randomised controlled trial of IBD-BOOST, a digital cognitive behavioural self-management programme for fatigue, and/or pain, and/or faecal incontinence in inflammatory bowel diseaseECCO'24Year: 2024
Authors: Norton, C.(1)*;Moss Morris, R.(2);Hart, A.(3);Cleirigh Buettner, F.(4);Hamborg, T.(5);Miller, L.(4);Stagg, I.(6);Aziz, Q.(7);Czuber-Dochan, W.(1);Dibley, L.(8);Mihaylova, B.(4);Pollok, R.(9);Roukas, C.(4);Saxena, S.(10);Sweeney, L.(2);Taylor, S.(4);Wileman, V.(2);
(1)King@E@s College London, Florence Nightingale Faculty of Nursing- Midwifery & Palliative Care, London, United Kingdom;(2)King@E@s College London, Institute of Psychiatry- Psychology and Neuroscience, London, United Kingdom;(3)St Mark@E@s Hospital & Imperial College, St Mark@E@s Academic Institute, London, United Kingdom;(4)Queen Mary University of London, Pragmatic Clinical Trials Unit, London, United Kingdom;(5)Queen Mary University of London, Pragmatic Clinical Trails Unit, London, United Kingdom;(6)St. Mark@E@s Hospital, Inflammatory Bowel Disease Unit, London, United Kingdom;(7)Queen Mary University of London, Blizzard Institute, London, United Kingdom;(8)Greenwich University, Centre for Chronic Illness and Ageing, London, United Kingdom;(9)St George Hospital, Gastroenterology, London, United Kingdom;(10)Imperial College London, Primary Care, London, United Kingdom;
P653: Impact of ozanimod on type III collagen turnover biomarkers and the association with ozanimod efficacy in patients with moderately to severely active ulcerative colitis: Results from the phase 3 True North studyECCO'24Year: 2024
Authors: D@E@Haens, G.(1)*;Maddux, R.(2);Wu, C.(2);Hu, Y.(2);Sands, B.E.(3);Mortensen, J.H.(4);Zhang, J.(2);Petersen, A.(2);Harris, S.(2);
(1)Amsterdam University Medical Center- Amsterdam- Netherlands- Department of Gastroenterology and Hepatology- University of Leuven, Gastroenterology and Hepatology, Leuven, Belgium;(2)Bristol Myers Squibb, n/a, Princeton, United States;(3)Icahn School of Medicine at Mount Sinai, Gastroenterology, New York, United States;(4)Nordic Bioscience, Gastroenterology, Herlev, Denmark;
