P067: Volumetric Assessment of Treatment Response in Newly Diagnosed Crohn Disease: A Pilot StudyECCO'24Year: 2024
Authors: Derinkuyu, B.E.(1);Bard, A.(2);Naim, I.(2)*; A. Tkach, J.(1);A. Denson, L.(1);R. Dillman, J.(1);
(1)University of Cincinnati College of Medicine, Department of Radiology- Cincinnati Children’s Hospital Medical Center, Cincinnati- OH, United States;(2)Motilent, Research department, London, United Kingdom;
P068: Recapitulation of human colonocytes in situ by human colon organoids in vitro and after orthotopic transplantationECCO'24Year: 2024
Authors: Hausmann, A.(1)*;Post, F.(2);Clement, D.L.(1);Skov, J.(1);Steenholdt, C.(3);Mund, A.(2);Nielsen, O.H.(3);Mann, M.(2);Jensen , K.B.(1);
(1)RENEW - NNF Center for Stem Cell Medicine, University of Copenhagen, Copenhagen, Denmark;(2)CPR - NNF Center for Proteome Research, University of Copenhagen, Copenhagen, Denmark;(3)Herlev Hospital, Gastroenterology, Copenhagen, Denmark;
P069: Ultra-processed food intake and dietary insufficiencies are common in adults with Crohn’s Disease in remission. The INTICO 2 StudyECCO'24Year: 2024
Authors: Westoby, C.(1)*;Katarachia, V.(2);McDonnell , M.(3);Sartain, S.(4);Cummings , F.(5);Wootton , S.(6);
(1)University Hospital Southampton NHS Foundation Trust, Nutition and Dietetics, Southampton, United Kingdom;(2)University Hospital Southampton NHS Foundation Trust, Nutrition and Dietetics, Southampton, United Kingdom;(3)University Hospital Southampton NHS Foundation Trust, Gastroenterology, Southampton, United Kingdom;(4)University Hospital Southampton NHS Foundation Trust- Department of Nutrition and Dietetics- Southampton- United Kingdom, Gastroenterology, Southampton, United Kingdom;(5)University Hospital Southampton NHS Foundation Trust-, Gastroenterology, Southampton, United Kingdom;(6)University of Southampton, Faculty of Medicine, Southampton, United Kingdom;INTICO 2
P070: The influence of Crohn’s disease-derived blood plasma upon anabolic signaling responses to leucine stimulation in skeletal muscle cells in vitroECCO'24Year: 2024
Authors: Fatani, H.(1)*;Kirkpatrick , E.(2);Atherton , P.(3);Moran, G.(4);Brook , M.(5);
(1)University of Nottingham, The Nottingham Digestive Diseases Centre NDDC- MRC-Versus Arthritis Centre for Musculoskeletal Ageing Research & NIHR Nottingham- School of Medicine, Nottingham, United Kingdom;(2)University of Nottingham, MRC-Versus Arthritis Centre for Musculoskeletal Ageing Research & NIHR Nottingham- School of Life Sciences, Nottingham, United Kingdom;(3)University of Nottingham, MRC-Versus Arthritis Centre for Musculoskeletal Ageing Research & NIHR Nottingham- Centre Of Metabolism- Ageing & Physiology COMAP-School of Medicine-, Nottingham, United Kingdom;(4)University of Nottingham, MRC-Versus Arthritis Centre for Musculoskeletal Ageing Research & NIHR Nottingham- The Nottingham Digestive Diseases Centre NDDC- School of Medicine, Nottingham, United Kingdom;(5)University of Nottingham, MRC-Versus Arthritis Centre for Musculoskeletal Ageing Research & NIHR Nottingham- Centre Of Metabolism- Ageing & Physiology COMAP- School of Life Sciences, Nottingham, United Kingdom;
P071: Neonatal levels of inflammatory markers in individuals who later develop early onset Inflammatory Bowel Disease.ECCO'24Year: 2024
Authors: Rudbæk, J.(1,2)*;Borbye-Lorenzen, N.(2);Poulsen, G.J.(1);Skogstrand, K.(2);Jess, T.(1,3);
(1)Aalborg University, Center for Molecular Prediction of Inflammatory Bowel Disease- Department of Clinical Medicine, Copenhagen, Denmark;(2)Statens Serum Institut, Section for Biomarkers- Immunology and Antibodies- Department for Congenital Disorders, Copenhagen, Denmark;(3)Aalborg University Hospital, Department of Gastroenterology & Hepatology, Aalborg, Denmark;
P072: LDN-071, a novel first-in-class amino acid-based PAI-1 inhibitor, significantly reduces the severity of experimental colitis in miceECCO'24Year: 2024
Authors: Jójárt, B.(1,2,3,4)*;Csákány-Papp, N.(2,3,4);Laub, H.(1,4);Vasas, B.(5);Barta, B.(6);Szabó, V.(2,3,4);Bagyánszki, M.(6);Mándity, I.(1,7);Heltovics, G.(1);Pallagi, P.(1,2,3,4);Maléth, J.(1,2,3,4);
(1)Ladon Therapeutics Ltd, Ladon Therapeutics Ltd, Szeged, Hungary;(2)HCEMM-USz, Molecular Gastroenterology Research Group, Szeged, Hungary;(3)University of Szeged, ELKH-USz Momentum Epithelial Cell Signaling and Secretion Research Group, Szeged, Hungary;(4)University of Szeged, Szent-Györgyi Albert Medical School- Department of Medicine, Szeged, Hungary;(5)University of Szeged, Szent-Györgyi Albert Medical School- Department of Pathology, Szeged, Hungary;(6)University of Szeged, Faculty of Science and Informatics- Department of Physiology- Anatomy and Neuroscience, Szeged, Hungary;(7)Research Centre for Natural Sciences, Institute of Materials and Environmental Chemistry- Artificial transporters Research Group, Budapest, Hungary;Ladon Therapeutics Ltd
P073: Enhancing the MFSD2A protein for the treatment of colitis-associated cancer: novel insights for pathogenesis and treatmentECCO'24Year: 2024
Authors: Cagliani, S.(1,2)*;Massimino, L.(1,3);Facoetti, A.(1);Spanò, S.(1,3);Errico, C.(1);Parigi, T.L.(1,2,3);Colasante, G.(4);Danese, S.(2,3);Ungaro, F.(1,3);
(1)San Raffaele Research Institute, Laboratory of Experimental Gastroenterology- Division of Immunology- Transplantation and Infectious Disease, Milan, Italy;(2)Vita-Salute San Raffaele University, Faculty of Medicine, Milan, Italy;(3)San Raffaele Hospital, Gastro Center- Gastroenterology and Digestive Endoscopy, Milan, Italy;(4)San Raffaele Research Institute, Stem Cell and Neurogenesis Unit- Division of Neuroscience, Milan, Italy;
P074: Inflammatory Environment-Induced Transcriptomic Alterations in Crohn@E@s Disease Adipose Stem CellsECCO'24Year: 2024
Authors: Montfort-Ferré, D.(1)*;Boronat-Toscano, A.(1);Sánchez-Herrero, J.F.(2);Caro, A.(3);Menacho, M.(4);Vañó-Segarra, I.(1);Martí, M.(5);Espina, B.(3);Pluvinet, R.(2);Cabrinety, L.(4);Abadia, C.(4);Ejarque, M.(1);Nuñez-Roa, C.(1);Maymo-Masip, E.(1);Sumoy, L.(2);Vendrell, J.(1);Fernández-Veledo, S.(1);Serena, C.(1);
(1)Health Institute Pere Virgili IISPV, Hospital Joan XXIII of Tarragona- Universitat Rovira i Virgili URV., Tarragona, Spain;(2)Germans Trias i Pujol Research Institute IGTP, High Content Genomics and Bioinformatics, Badalona, Spain;(3)Hospital Joan XXIII of Tarragona, Surgery Service, Tarragona, Spain;(4)Hospital Joan XXIII of Tarragona, Gastroenterology Service, Tarragona, Spain;(5)Hospital Vall d@E@Hebron of Barcelona, Surgery Service, Barcelona, Spain;
P075: Early intestinal ultrasound non-response is a prediction tool of complicated disease outcome in Crohn’s disease patients treated with infliximabECCO'24Year: 2024
Authors: Bárbara, A.(1)*;Bravo, C.(1);Reves, J.(1);Nascimento, C.(1);Gomes, C.(1);Torres, J.(1);Palmela, C.(1);
(1)Hospital Beatriz Ângelo, Gastroenterology, Lisbon, Portugal;
P076: Dock2 acts as a tumour suppressor via immune cell regulation of IDO1 in Inflammatory Bowel Disease–associated colorectal cancerECCO'24Year: 2024
Authors: ChurchhouseMD, A.(1)*;Billard, C.V.(1);Pohl, S.Ö.(1);Donnelly, K.(1);Suzuki, T.(2);Von Kriegsheim, A.(1);Arends, M.J.(1);Coffelt, S.B.(2);Myant, K.B.(1);
(1)The University of Edinburgh, The Institute of Genetics and Cancer, Edinburgh, United Kingdom;(2)University of Glasgow, School of Cancer Sciences, Glasgow, United Kingdom;
P077: The Immunometabolic Bimodal Mechanism of NLRX1 Agonist NX-13 in a Pig Model of Ulcerative ColitisECCO'24Year: 2024
Authors: Verstockt, B.(1)*;Mosig, R.(2);Dubinsky, M.(3);Cataldi, F.(4);Danese, S.(5);
(1)University Hospitals Leuven- KU Leuven-, Department of Gastroenterology and Hepatology- Department of Chronic Diseases and Metabolism, Leuven, Belgium;(2)Landos Biopharma- Inc, Corporate Development, Blacksburg, United States;(3)Mount Sinai Kravis Children@E@s Hospital- Icahn School of Medicine Mount Sinai, Division of Pediatric Gastroenterology and Nutrition, New York, United States;(4)Landos Biopharma- Inc, Medicine, Boston, United States;(5)IRCCS San Raffaele Scientific Institute- Vita-Salute San Raffaele University, Gastroenterology and Gastrointestinal Endoscopy Unit, Milan, Italy;
P078: Inflammatory transcriptomic signatures and cell type compositions in colonic mucosa of ulcerative colitisECCO'24Year: 2024
Authors: Song, E.M.(1)*;Jung, S.A.(1);Joo, Y.H.(1);Moon, C.M.(2);Kim, J.(3);
(1)College of Medicine- Ewha Womans University, Departments of Internal Medicine, Seoul, Korea- Republic Of;(2)College of Medicine- Ewha Womans University, Departments of Internal Medicine-, Seoul, Korea- Republic Of;(3)Soongsil University, School of Systems Biomedical Science, Seoul, Korea- Republic Of;
P079: Low-intensity Pulsed Ultrasound reflects the status of mucosal injury and repair through stage-specific miRNAs in experimental model of Ulcerative ColitisECCO'24Year: 2024
Authors: Pineda Chavez, S.E.(1)*;Carriles Linares, A.(1);Rizzo, G.(2);Wozny, M.(1);Cafarelli, A.(3,4);Mori, G.(2);Sorriento, A.(3,4);Loy, L.(5);Dal Buono, A.(5);Gabbiadini, R.(5);Bezzio, C.(5);Lucchetti, D.(6);Sgambato, A.(6);Ricotti, L.(3,4);Repici, A.(1,7);Armuzzi, A.(1,5);Vetrano, S.(1,2);
(1)Humanitas University, Biomedical Sciences, Pieve Emanuele- Milan, Italy;(2)IRCCS Humanitas Research Hospital, Laboratory of Gastrointestinal Immunopathology- Department of Gastroenterology, Rozzano- Milan, Italy;(3)Scuola Superiore Sant’Anna, The BioRobotics Institute, Pisa, Italy;(4)Scuola Superiore Sant’Anna, Department of Excellence in Robotics & AI, Pisa, Italy;(5)Humanitas Clinical and Research Center - IRCCS -, IBD Unit- Department of Gastroenterology, Rozzano- Milan, Italy;(6)Università Cattolica del Sacro Cuore, Institute of General Pathology, Rome, Italy;(7)Humanitas Clinical and Research Center-IRCCS, Endoscopy Unit, Rozzano- Milan, Italy;
P080: High faecal pH and low total microbial load associate with normalisation of faecal calprotectin in children with Crohn’s disease treated with exclusive enteral nutrition; results from iPENS, a multicentre, prospective studyECCO'24Year: 2024
Authors: Gkikas, K.(1)*;Lima, M.(1);McKirdy, S.(1);Nichols, B.(1);Kerbiriou, C.(1);Gervais, L.(2);Smith, G.(3);Armstrong, L.(4);Jordan, T.(3);Chalmers, I.(5,6);Barlow, H.(7);Al Hourani, G.(8);Muhammed, R.(9);Wands, D.(2);Narula, P.(10);Patel, M.(11);Ijaz, U.Z.(12);Milling, S.(13);Gasparetto, M.(14);Henderson, P.(15);Wilson, D.C.(15);Hansen, R.(2,16);Russell, R.K.(15);Gerasimidis, K.(1);
(1)University of Glasgow, School of Medicine- Dentistry and Nursing, Glasgow, United Kingdom;(2)Royal Hospital for Children, Department of Paediatric Gastroenterology- Hepatology and Nutrition, Glasgow, United Kingdom;(3)University Hospital Wishaw, Department of Paediatrics, Wishaw, United Kingdom;(4)University Crosshouse Hospital, Department of Paediatrics, Crosshouse, United Kingdom;(5)Aberdeen Children@E@s Hospital, Department of Paediatric Gastroenterology, Aberdeen, United Kingdom;(6)Tayside Children@E@s Hospital, Department of Paediatric Gastroenterology, Dundee, United Kingdom;(7)Royal Manchester Children@E@s Hospital, Department of Paediatrics, Manchester, United Kingdom;(8)Forth Valley Royal Hospital, Department of Paediatrics, Larbert, United Kingdom;(9)Birmingham Women@E@s and Children@E@s Hospital, Department of Paediatric Gastroenterology, Birmingham, United Kingdom;(10)Sheffield Children@E@s Hospital, Department of Paediatric Gastroenterology, Sheffield, United Kingdom;(11)Royal London Children@E@s Hospital, Department of Paediatric Gastroenterology, London, United Kingdom;(12)University of Glasgow, James Watt School of Engineering, Glasgow, United Kingdom;(13)University of Glasgow, School of Infection and Immunity, Glasgow, United Kingdom;(14)Norfolk and Norwich University Hospitals, Department of Paediatric Gastroenterology, Norwich, United Kingdom;(15)Royal Hospital for Children and Young People, Department of Paediatric Gastroenterology- Hepatology and Nutrition, Edinburgh, United Kingdom;(16)University of Dundee, Department of Child health- Division of Clinical and Molecular Medicine- School of Medicine, Dundee, United Kingdom;
P081: The integration of transcriptomic and microbiomic data links several intestinal bacterial families with key biological functions in the development of postoperative recurrence in Crohn@E@s disease.ECCO'24Year: 2024
Authors: Cabrer, M.(1);Suau, R.(1)*;Lopez-Siles, M.(2);Martinez-Medina, M.(2);Aterido, A.(3,4);Julià, T.(3);Zabana, Y.(5,6);Calafat, M.(1,6,7);Clua, L.(1);Lorén, V.(1);Domènech, E.(1,6,7);Mañosa, M.(1,6,7);Manyé, J.(1,6);
(1)Germans Trias i Pujol Research Institute IGTP, IBD Research Group, Badalona, Spain;(2)Biology Departament- University of Girona, Research Group in Microbiology of intestinal disease, Girona, Spain;(3)Vall d@E@Hebron Research Institute VHIR, Rheumatology Research Group, Barcelona, Spain;(4)Pompeu Fabra University, Department of Experimental and Health Sciences, Barcelona, Spain;(5)MútuaTerrassa University Hospital, Digestive Tract Service, Terrassa, Spain;(6)Centro de Investigación Biomédica en Red CIBER, Enfermedades Hepáticas y Digestivas CIBEREHD, Madrid, Spain;(7)Germans Trias i Pujol University Hospital HUGTP, Digestive Tract Service, Badalona, Spain;
P082: Downregulated apelin expression in T cells in the setting of Chronic ColitisECCO'24Year: 2024
Authors: Inoue, T.(1)*;Fushimi, M.(1);Yamada, D.(1);Watabe, T.(1);Watanabe, M.(1);Okamoto, R.(1);Nagaishi, T.(1);
(1)Tokyo Medical and Dental University, Gastroenterology, Tokyo, Japan;
P083: Dietary-derived ω-3 and ω-6 polyunsaturated fatty acids trigger an inflammatory response in intestinal epithelial cells with chemically inhibited GPX4 activityECCO'24Year: 2024
Authors: Schwärzler, J.P.(1)*;Mayr, L.(1);Grabherr, F.(1);Meyer, M.(1);Jukic, A.(1);Tilg, H.(1);Adolph, T.E.(1);
(1)Medical University of Innsbruck, Department of Internal Medicine I- Gastroenterology- Hepatology- Endocrinology & Metabolism, Innsbruck, Austria;
P084: Natural extracts and omega-3 derived molecule: role in resolution of intestinal inflammationECCO'24Year: 2024
Authors: Camba Gómez, M.(1)*;Arosa, L.(1); Ait Eldjoudi, D.(2);Gonzalez-Rodríguez , M.(2);Gualillo, O.(2);Conde-Aranda, J.(1);
(1)Health Research Institute of Santiago de Compostela IDIS, Molecular and Cellular Gastroenterology, Santiago de Compostela, Spain;(2)Health Research Institute of Santiago de Compostela IDIS, Neuroendocrine Interactions in Rheumatology and Inflammatory Diseases NEIRID, Santiago de Compostela, Spain;
P085: Tc17 cells with a distinct immune signature do not correlate with response to therapy with ustekinumab or TNF antibodies in active Crohn’s DiseaseECCO'24Year: 2024
Authors: Szentandrasi, J.(1)*;Hockenjos, B.(1);Reinscheid, M.(1);Thimme, R.(1);Bengsch, B.(1);Hasselblatt, P.(1);Mayer, L.S.(1);
(1)University Medical Center and Faculty of Medicine- University of Freiburg, Department of Medicine II: Gastroenterology- Hepatology- Endocrinology- and Infectious Disease, Freiburg, Germany;
P086: Identification of a Novel Immunometabolic Target and Agonist for PLXDC2 for Amelioration of DSS Colitis Model in MiceECCO'24Year: 2024
Authors: Abdurahiman, S.(1);Mosig, R.(2);Cataldi, F.(3);Vermeire, S.(1);Verstockt, B.(1)*;
(1)University Hospitals Leuven- KU Leuven-, Department of Gastroenterology and Hepatology- Department of Chronic Diseases and Metabolism, Leuven, Belgium;(2)Landos Biopharma- Inc, Corporate Development, Blacksburg, United States;(3)Landos Biopharma- Inc, Clinical, Boston, United States;
