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P077 Metabonomic profiling distinguishes Crohn’s perianal fistulas and idiopathic idiopathic (cryptoglandular) perianal fistulas: possible clues to underlying pathogenesis?

ECCO'20 Vienna

Year: 2020
Authors:

S. Adegbola1, M. Sarafian2, K. Sahnan1, P. Tozer1, N. Ding3, O. Faiz1, J. Warusavitarne1, R. Phillips1, E. Holmes2, A. Hart3

1St. Mark’s Hospital, Department of Colorectal Surgery, Harrow, UK, 2Imperial College London, Computational Systems Division, London, UK, 3St. Mark’s Hospital, Inflammatory Bowel Diseases Unit, Harrow, UK

P078 Efficiency of evaluating the expression of Toll-like receptors 2, 4, 6 and proteins proteomic profiling as integral indicators for predicting the risk of early relapse of ulcerative colitis

ECCO'20 Vienna

Year: 2020
Authors:

G. Tarasova, A. Volkov, A. Iakovlev, T. Ghazudin, I. Shcherbakova

Rostov State Medical University, Gastroenterology, Rostov-on-Don, Russian Federation

P079 High-dimensional mass cytometry after local MSC treatment in patients with refractory proctitis shows an effect on the myeloid compartment: preliminary data

ECCO'20 Vienna

Year: 2020
Authors:

L. Ouboter Drs.1,2, M.C. Barnhoorn1, L.J.A.C. Hawinkels1, M. van Pel2, J.J. Zwaginga2, H.W. Verspaget1, F. Koning2, M.F. Pascutti2, A.E. van der Meulen-de Jong1

1Leiden University Medical Center, Gastroenterology and Hepatology, Leiden, The Netherlands, 2Leiden University Medical Center, Immunohematology and Blood Transfusion, Leiden, The Netherlands

P080 Therapeutical effect of urine-derived stem cells on DSS-induced chronic model of mice

ECCO'20 Vienna

Year: 2020
Authors:

X.R. Wu, C. Zhou, H.S. Liu, L. Xuan-hui, T. Hu, X.B. Zheng, Z.X. Liang, X.J. Wu, X. Gao, X.S. He, J. Ke, Y.F. Chen, X.W. He, J.C. Hu, Y. Zou, P. Lan

The Sixth Affiliated Hospital, Sun Yat-Sen University South Campus, Department of Colorectal Surgery, Guangzhou, China

P081 The structure of the proteomic profile and gut microbiota in patients with primary immunodeficiency, common variable immunodeficiency and inflammatory bowel disease

ECCO'20 Vienna

Year: 2020
Authors:

A.A. Iakovlev, A. Volkov, O. Bashtovaya, I. Shcherbakova, T. Ghazudin, G. Leonova, G. Tarasova

Rostov State Medical University, Department of Gastroenterology, Rostov-on-Don, Russian Federation

P082 Spicy food is a vital trigger for relapse in patient with inflammatory bowel disease

ECCO'20 Vienna

Year: 2020
Authors:

Y. Chen, C. Ma, Y. Dang, K. Chen, S. Shen, M. Jiang, Z. Zeng, H. Zhang

West China Hospital, Gastroenterology, Chengdu, China

P083 Characterisation of T-cell receptor repertoire patterns of circulating a4b7 positive memory T cells in ulcerative colitis

ECCO'20 Vienna

Year: 2020
Authors:

A. Gamliel, L. Werner, N. Salamon, M. Pinsker, B. Weiss, D. Shouval

Tel-HaShomer Sheba Medical Center Edmond and Lily Safra Childrens Hospital, Paediatric Gastroenterology Unit, Ramat-Gan, Israel

P084 Cannabis use promotes lymphocyte responsiveness and modifies T-cell signalling in adolescent IBD patients

ECCO'20 Vienna

Year: 2020
Authors:

M. Sanctuary1, C. Wilkinson2, A. Jones2, B. Murphy3, E. Hoffenberg3, C. Collins4

1University of Colorado Denver, Mucosal Inflammation Program, Pediatrics, Aurora, USA, 2University of Colorado, Mucosal Inflammation Program, Pediatrics, Aurora, USA, 3Children’s Hospital Colorado, Pediatrics, Aurora, USA, 4University College Dublin, Pharmacology, Dublin, Ireland

P085 Deep profiling of the circulating immune cell landscape in inflammatory bowel disease by mass cytometry

ECCO'20 Vienna

Year: 2020
Authors:

V. Horn1,2, Z. Borek1,2, E. Mantzivi1, M. Urbicht3, D. Boesel1,2, S. Baumgart3, E. Sonnenberg1, D. Lissner1, B. Siegmund1, H. Mei3, A.N. Hegazy MD, PhD1

1Charité – University Medicine Berlin- CBF and German Rheumatism Research Center-Berlin, Department of Gastroenterology, Infectiology and Rheumatology, Berlin, Germany, 2Deutsches Rheuma-Forschungszentrum, ein Institut der Leibniz-Gemeinschaft, Inflammatory Mechanisms Group, Berlin, Germany, 3Deutsches Rheuma-Forschungszentrum, ein Institut der Leibniz-Gemeinschaft, Mass Cytometry Group, Berlin, Germany

P086 Identification of constitutive modifications in plasma cells and B lymphocytes in patients with inflammatory bowel disease

ECCO'20 Vienna

Year: 2020
Authors:

A.C. Marin1, S. Fernández-Tomé1, L. Ortega Moreno2, V. Martin Dominguez3, S. Casabona3, I. Becerro3, I. Mora-Gutiérrez1, I. Villacañas-Gil1, M. Baldan-Martin1, J.A. Moreno-Monteagudo3, C. Santander2, M. Chaparro2, D. Bernardo1,4,5, J.P. Gisbert2,5

1Hospital Universitario de La Princesa, Department of Gastroenterology, IIS-IP and CIBERehd, Madrid, Spain, 2Hospital Universitario de La Princesa, Department of Gastroenterology, IIS-IP and CIBERehd. Departamento de Medicina. Universidad Autónoma de Madrid., Madrid, Spain, 3Hospital Universitario de La Princesa, Department of Gastroenterology, IIS-IP, Madrid, Spain, 4Instituto de Biología y Genética Molecular IBGM, Mucosal Immunology Lab. Universidad de Valladolid-CSIC., Valladolid, Spain, 5Both authors had equal contribution, as senior authors, Madrid, Spain

P087 Biomarkers of elastin degradation differentiate between clinically inactive and active disease in ulcerative colitis patients

ECCO'20 Vienna

Year: 2020
Authors:

M. Pehrsson1, V. Domislović2, M.A. Karsdal1, M. Brinar2, A. Barisic3, Z. Krznaric2, T. Manon-Jensen1, J.H. Mortensen1

1Nordic Bioscience A/S, Biomarkers and Research, Herlev, Denmark, 2University Hospital Centre Zagreb, Department of Gastroenterology and Hepatology, Zagreb, Croatia, 3University Hospital Centre Zagreb, Department for Clinical Nutrition, Zagreb, Croatia

P088 TLR3 ameliorates colitis-associated colon tumourigenesis in mice

ECCO'20 Vienna

Year: 2020
Authors:

Y.K. Jun1,2,3, S.J. Koh1,3, H.W. Gang4, K.Y. Chung1,3, J.M. Han1, J.W. Kim1,3, B.G. Kim1, K.L. Lee1, J.P. Im2, J.S. Kim2

1Division of Gastroenterology and Hepatology, Department of Internal Medicine, SMG-SNU Boramae medical Center, Seoul, Republic of Korea, 2Division of Gastroenterology and Hepatology, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea, 3Laboratory of Intestinal Mucosa and Skin Immunology, SMG-SNU Boramae medical Center, Seoul, Republic of Korea, 4Division of Gastroenterology- Department of Internal Medicine, Dongguk University Ilsan Hospital, Goyang, Republic of Korea

P089 Immune system cell differences between Crohn’s disease and ulcerative colitis patients in remission under anti TNF treatment

ECCO'20 Vienna

Year: 2020
Authors:

S. Notararigo1, J.E. Viñuela Roldán2, A. Quiroga3, J.E. Dominguez-Munoz3, M. Barreiro-de Acosta3

1FIDIS, Laboratory of Gastroenterology, Santiago de Compostela, Spain, 2University Hospital, Immunology Laboratory, Santiago, Spain, 3University Hospital Santiago De Compostela CHUS, Department of Gastroenterology- IBD Unit, Santiago De Compostela, Spain

P090 Influence of high-fat diet on colitis and liver health in inflammatory bowel disease: a study using murine model of DSS-induced colitis

ECCO'20 Vienna

Year: 2020
Authors:

A.R. Choe, S.E. Kim, H.A. Lee, S.G. Yoo, T.O. Kim, C.H. Tae, C.M. Moon, H.K. Jung, K.N. Shim, S.A. Jung

Ewha Womans University, Department of Internal Medicine, Seoul, Republic of Korea

P091 Dietary triggers of colonic inflammation following treatment with exclusive enteral nutrition in children with Crohn’s disease

ECCO'20 Vienna

Year: 2020
Authors:

K. Gkikas1, M. Logan1, B. Nichols1, C.M. Clark1, U.Z. Ijaz2, L. Gervais3, H. Duncan3, V. Garrick3, L. Curtis3, E. Buchanan3, T. Cardigan3, L. Armstrong4, C. Delahunty5, D.M. Flynn3, A.R. Barclay3, R. Tayler3, R. Hansen3, R.K. Russell3, K. Gerasimidis1

1University of Glasgow, School of Medicine, Glasgow, UK, 2University of Glasgow, School of Engineering, Glasgow, UK, 3Royal Hospital for Children, Paediatric Gastroenterology, Hepatology and Nutrition, Glasgow, UK, 4Crosshouse Hospital, Department of Paediatrics, Kilmarnock, UK, 5Wishaw General Hospital, Department of Paediatrics, Wishaw, UK

P092 Pathogenic B-cell response in ulcerative colitis that associates with treatment resistance and disease complications

ECCO'20 Vienna

Year: 2020
Authors:

M. Uzzan1, J. Martin2, E. Keningsberg2, T. Castro-Dopico3, R. Huang4, R. Ungaro1, B. Cohen1, A. Rahman5, A. Rosenstein1, S. Gurunathan1, M. Dubinsky1, M. Clatworthy3, M. Suarez-Farinas6, C. Argmann6, J.F. Colombel1, S. Mehandru7

1Icahn School of Medicine at Mount Sinai, Gastroenterology, New York, USA, 2Icahn School of Medicine at Mount Sinai, Precision Immunology Institute, New York, USA, 3University of Cambridge, Medicine, Cambridge, UK, 4Icahn School of Medicine at Mount Sinai, Population Health Science and Policy, New york, USA, 5Icahn School of Medicine at Mount Sinai, Human Immune Monitoring Center, New York, USA, 6Icahn School of Medicine at Mount Sinai, Genetics and Genomics, New York, USA, 7Icahn School of Medicine at Mount Sinai, Department of Medicine Gastroenterology, New York City, USA

P093 Crosstalk between Toll-like receptor 4 and enteric serotonergic pathways in a mouse model of dinitrobenzene sulfonic acid-induced colitis

ECCO'20 Vienna

Year: 2020
Authors:

S. Cerantola1, M. Ridolfi1, S. Faggin1, M. Tegon1, G. Bussolaro1, E. Salviato1, M. Bistoletti2, V. Caputi1, C. Giaroni2, M.C. Giron1

1University of Padova, Department of Pharmaceutical and Pharmacological Sciences, Padova, Italy, 2University of Insubria, Department of Medicine and Surgery, Varese, Italy

P094 Differences in expression of PPARγ in small intestine vs. colon impact the effect of 5-aminosalicylates in inflammatory bowel disease

ECCO'20 Vienna

Year: 2020
Authors:

I. Bakke1,2, T. Bruland1,2, K.S. Eriksen1, H.K. Skovdahl1, S. Gopalakrishnan1, S. Thorsvik1,2,3, A.V.B. Granlund1,4, A.K. Sandvik1,2,3,4, A.E. Østvik MD1,2,3

1Norwegian University of Science and Technology, Department of Clinical and Molecular Medicine- Faculty of Medicine and Health Sciences, Trondheim, Norway, 2St Olavs Hospital, Trondheim University Hospital, Clinic of Medicine, Trondheim, Norway, 3St. Olav`s University Hospital, Department of Gastroenterology, Clinic of Medicine, Norway, Trondheim, Norway, 4Norwegian University of Science and Technology, Centre of Molecular Inflammation Research, NTNU, Trondheim, Norway

P095 PD-1 expressing T cells in patients with different types of colitis

ECCO'20 Vienna

Year: 2020
Authors:

B. Roosenboom1, C. Horjus Talabur Horje1, C. Smids1, J.W. Leeuwis2, E. Van Koolwijk3, M. Groenen1, P. Wahab1, E. Van Lochem3

1Rijnstate Hospital, Department of Gastroenterology and Hepatology, Arnhem, The Netherlands, 2Rijnstate Hospital, Department of Pathology, Arnhem, The Netherlands, 3Rijnstate Hospital, Department of Microbiology and Immunology, Arnhem, The Netherlands

P096 Specific plasma micro-RNA profiles for prediction of recurrence in Crohn’s disease in pre-surgery and established recurrence scenarios

ECCO'20 Vienna

Year: 2020
Authors:

I. Moret1,2, E. Cerrillo1,3, E. Saez-Gonzalez1,3, D. Hervas4, M. Iborra1,2,3, L. Tortosa1,2, P. Nos1,2,3, J. Gadea5, B. Beltran1,2,3

1IIS Hospital la Fe, Inflammatory Bowel Disease Research Group, Valencia, Spain, 2Biomedical Research Centre- Hepatic and Digestive Diseases Network, CIBERehd, Madrid, Spain, 3Hospital la Fe, Gastroenterology, Valencia, Spain, 4IIS Hospital la Fe, Biostatistics Unit, Valencia, Spain, 5Universitat Politecnica de Valencia, IBMCP. Instituto de Biologia Molecular y Celular de Plantas, Valencia, Spain