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P071: Supporting extrapolation of indications for ABP 501, the first adalimumab biosimilar: focus on Crohn’s disease

ECCO '19 Copenhagen

Year: 2019
Authors:

S. Halder*1, W. Khan1, X. Wang1, S. Kuhns2, H. Sweet2, W. Reinisch1, H. McBride2

1McMaster, Ontario, Canada, 2Amgen, Thousand Oaks, USA

P072: Quantitative phase imaging for the characterisation of Crohn’s disease-derived intestinal strictures

ECCO '19 Copenhagen

Year: 2019
Authors:

A. Bokemeyer*1, P. Tepasse1, L. Quill1, P. Lenz2, E. Rijcken3, M. Vieth4, S. Ketelhut5, F. Rieder6, B. Kemper7, D. Bettenworth1

1University Hospital Münster, Department of Medicine B for Gastroenterology and Hepatology, Münster, Germany, 2University Hospital Münster, Institute of Palliative Care, Münster, Germany, 3University Hospital Münster, Department of General and Visceral Surgery, Münster, Germany, 4Klinikum Bayreuth, Institute of Pathology, Bayreuth, Germany, 5University of Münster, Biomedical Technology Center, Münster, Germany, 6Cleveland Clinic, Department of Gastroenterology, Hepatology and Nutrition, Digestive Diseases and Surgery Institute, Cleveland, USA, 7University of Muenster, Biomedical Technology Center, Münster, Germany

P073: Evaluation of DPPH free radical scavenging activity by HPLC technique: a screening method for drugs and nutrients used in inflammatory bowel disease

ECCO '19 Copenhagen

Year: 2019
Authors:

M-L. Jelicic1, E. Brusac1, D. Amidzic Klaric1, B. Nigovic1, N. Turk*2, Z. Krznaric2, A. Mornar1

1Faculty of Pharmacy and Biochemistry, University of Zagreb, Department of Pharmaceutical Analysis, Zagreb, Croatia, 2University Hospital Center, Department of Gastroenterology and Hepatology, Zagreb, Croatia

P074: Autoimmunity against type IV collagen in ulcerative colitis

ECCO '19 Copenhagen

Year: 2019
Authors:

D. Abdulganieva*1, D. Mukhametova1, O. Zinkevich2, N. Safina2, M. Koporulina2, A. Odintsova3

1Kazan State Medical University, Hospital therapy, Kazan, Russian Federation, 2Kazan State Medical Academy, Kazan, Russian Federation, 3Republican Clinical Hospital, Kazan, Russian Federation

P075: Adaptive defensive response is critical to determine dextran sulphate sodium-induced colitis

ECCO '19 Copenhagen

Year: 2019
Authors:

K. B. Hahm*1, D. W. Kim1, K. J. Kim2

1CHA University, Gastroenterology, Seongnam, South Korea, 2Univ of Ulsan, Gastroenterology, Seoul, South Korea

P076: Conserved inflammatory profile between mice and humans allow unsupervised patient stratification and temporal allocation of IBD-risk genes

ECCO '19 Copenhagen

Year: 2019
Authors:

P. Czarnewski1, M. Parigi1, O. Diaz1, S. Das1, C. Sorini1, N. Gagliani1, E. J. Villablanca*1

1Karolinska Institute, Medicine, Stockholm, Sweden

P077: SMAD7 shows a biphasic expression pattern during progression of ulcerative colitis-associated colorectal cancer

ECCO '19 Copenhagen

Year: 2019
Authors:

P. Chandrasinghe*1,2,3, B. Cereser2, M. Moorghen4, P. Spaggiari5, A. Maroli5, L. Del Bel Belluz2, A. Hart6, A. Spinelli5,7, J. Stebbing2, J. Warusavitarne1

1St Mark's Hospital, Department of Colorectal Surgery, London, UK, 2Imperial College London, Department of Surgery and Cancer, London, UK, 3University of Kelaniya, Department of Surgery, Kelaniya, Sri Lanka, 4St Mark's Hospital, Department of Pathology, London, UK, 5Humanitas Clinical and Research Center, Division of Colon and Rectal Surgery, Milan, Italy, 6St Mark's Hospital, Department of Gastroenterology, London, UK, 7Humanitas University, Department of Biomedical Sciences, Milan, Italy

P078: Mucosal tissue short chain fatty acids contribute to prediction of pouchitis in restorative proctocolectomy

ECCO '19 Copenhagen

Year: 2019
Authors:

J. Segal*1, M. Sarafian2, J. I. Serrano Contreras2, A. Pechlivanis2, L. Braz1,2, Y. Siaw3, S. Clark1,2, E. Holmes2, A. Hart1,2

1St Marks Hospital, Gastroenterology, Harrow, UK, 2Imperial College London, London, UK, 3Hillingdon Hospital, Gastroenterology, Hillingdon, UK

P079: Increased faecal proteolytic activity in pouchitis patients mediates epithelial barrier disruption through activation of protease-activated receptor-2

ECCO '19 Copenhagen

Year: 2019
Authors:

S. Hoffman*1, I. M. Carrol2, H. Tulchinski3,4, I. Borovok5, I. Dotan6

1Tel Aviv medical Center, Digestive and liver Disease Research Center, Tel Aviv, Israel, 2University of North Carolina, Center for Gastrointestinal Biology and Disease, School of Medicine, Chapel Hill, USA, 3Tel Aviv Medical Center, Division of Surgery Colorectal Unit, Tel Aviv, Israel, 4Tel-Aviv University, Sackler Faculty of Medicine, Tel Aviv, Israel, 5Tel-Aviv University, Department of Molecular and Microbiology and Biotechnology, Tel Aviv, Israel, 6Rabin Medical Center, Division of Gastroenterology, Petah Tikva, Israel

P080: Thioguanine nucleotide cut-off levels to predict leucopoenia should be considered differently based on NUDT15 R139C genotypes in Chinese Crohn’s disease

ECCO '19 Copenhagen

Year: 2019
Authors:

X. Zhu1, K. Chao2, H. Zheng1, P. Hu2, M. Huang1, X. Gao*2, X. Wang1

1Sun Yat-sen University, Guangzhou, China, 2The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China

P081: Effect of bile acid on lymphocyte migration in the small intestine

ECCO '19 Copenhagen

Year: 2019
Authors:

N. Shibuya*1, M. Higashiyama1, S. Nishii1, A. Mizoguchi1, K. Inaba1, N. Sugihara1, Y. Hanawa1, A. Wada1, K. Horiuchi1, H. Furuhashi1, C. Kurihara1, H. Hozumi1, Y. Okada1, C. Watanabe1, S. Komoto1, K. Tomita1, S. Nagao1, M. Saruta2, R. Hokari1

1National Defense Medical College, Internal Medicine, Tokorozawa, Japan, 2Jikei University School of Medicine, Internal Medicine, Tokyo, Japan

P082: Xenobiotic nuclear receptors: linking bile acid signalling to alterations in CYP3A4 metabolism in Crohn's disease

ECCO '19 Copenhagen

Year: 2019
Authors:

A. Wilson*1, A. Almousa2, R. Rose3, W. Teft2, R. Kim1

1Western University, Medicine, London, Canada, 2Western University, Physiology and Pharmacology, London, Canada, 3Western University, Epidemiology and Biostatistics, London, Canada

P083: The transcriptomic signature of IL-23-treated lamina propria mononuclear cells is significantly enriched for genes in the Th17 pathway and is enriched in active UC

ECCO '19 Copenhagen

Year: 2019
Authors:

J. Digby-Bell1, P. Pavlidis1, U. Niazi2, Z. Kassam1, N. Prescott3, E. Perucha1, M. Saqi2, N. Powell1

1King's College London, Centre for Inflammation and Cancer Immunology (CIBCI), London, UK, 2King's College London, NIHR Biomedical Research Center, London, UK, 3King's College London, Department of Medical and Molecular Genetics, London, UK

P084: Clinical response to Ustekinumab in Crohn’s disease is linked to a dose-dependent reduction of T follicular helper cells

ECCO '19 Copenhagen

Year: 2019
Authors:

A-M. Globig*1,2, N. P. Sommer1, A. K. Thomann3, W. Reindl3, R. Schreiner4, M. Hofmann1, C. Schempp5, R. Thimme1, P. Hasselblatt1

1Medical Center – University of Freiburg, Department of Medicine II, Freiburg, Germany, 2Faculty of Medicine, University of Freiburg, Berta-Ottenstein-Programme, Freiburg, Germany, 3Medical Faculty Mannheim, Heidelberg University, Department of Medicine II, Mannheim, Germany, 4Limbach Group, Heidelberg, Germany, 5Medical Center – University of Freiburg, Department of Dermatology, Freiburg, Germany

P085: Crohn’s disease patients under combined therapy with Azathioprine and Infliximab present persistent inflammation together with a counter regulatory response during clinical disease remission

ECCO '19 Copenhagen

Year: 2019
Authors:

M. Duarte-Silva1,2, R. S. Parra*3, M. R. Feitosa3, O. Féres3, J. J. Ribeiro da Rocha3, C. R. d1, B. Cardoso1

1School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil, Department of Clinical Analysis, Toxicology and Food Science, Ribeirão Preto, SP, Brazil, 2Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, São Paulo, Brazil, Department of Immunology and Biochemistry, Ribeirão Preto, Brazil, 3Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil, Surgery and Anatomy, Ribeirão Preto, SP, Brazil

P086: Eukaryotic microbial dysbiosis in treatment-naïve patients with newly diagnosed Crohn’s disease

ECCO '19 Copenhagen

Year: 2019
Authors:

I. Goren*1,2, L. Reshef3, L. Godny1, K. Rabinowitz1, I. Dotan1,2, H. Yanai1,2

1Rabin Medical Center, Division of Gastroenterology, Petah Tikva, Israel, 2Tel Aviv University, Sackler Faculty of Medicine, Tel Aviv, Israel, 3Tel Aviv University, Department of Molecular Microbiology and Biotechnology, Tel Aviv, Israel

P087: Urinary formate and glycine are associated with treatment response in patients treated with antibiotics for pouchitis

ECCO '19 Copenhagen

Year: 2019
Authors:

J. Segal*1, M. Sarafian2, J. I. Serrano Contreras2, A. Pechlivanis2, L. Braz1,2, Y. Siaw3, S. Clark1,2, E. Holmes2, A. Hart1,2

1St Marks Hospital, Gastroenterology, Harrow, UK, 2Imperial College London, London, UK, 3Hillingdon Hospital, Gastroenterology, Hillingdon, UK

P088: Transcriptome landscape of protein-coding genes and long noncoding RNAs in the colon and blood of DSS-induced mouse model of Acute ulcerative colitis

ECCO '19 Copenhagen

Year: 2019
Authors:

R. Yarani*1, O. Palasca2,3, N. Tsankova Doncheva2,3, C. Anthon3,4, B. Pilecki5, T. Litman6, U. Holmskov5, L. J. Jensen2,3, J. Gorodkin3,4, F. Pociot1,7,8

1Type 1 Diabetes Biology, Department of Clinical Research, Steno Diabetes Center Copenhagen, Gentofte, Denmark, 2Novo Nordisk Foundation Center for Protein Research, University of Copenhagen, Copenhagen, Denmark, 3Center for non-coding RNA in Technology and Health, University of Copenhagen, Copenhagen, Denmark, 4Department of Veterinary and Animal Sciences, University of Copenhagen, Copenhagen, Denmark, 5Department of Cancer and Inflammation Research, Institute of Molecular Medicine, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark, 6Department of Immunology and Microbiology, University of Copenhagen, Copenhagen, Denmark, 7Copenhagen Diabetes Research Center, Department of Pediatrics, Herlev University Hospital, Herlev, Denmark, 8Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark

P089: Extensive characterisation of cellular sources of IL-22BP in inflammatory bowel diseases indicates that T cells do not express IL-22BP

ECCO '19 Copenhagen

Year: 2019
Authors:

A. Fantou*1,2, A. Abidi1, L. Delbos1, J. Podevin3, A. Jarry4, M. Heslan1, J. Martin1,2, A. Bourreille5,6, R. Josien1,2

1Centre de Recherche en Transplantation et Immunologie UMR 1064, Inserm, Université de Nantes, CHU Nantes, 44000 Nantes, France, 2Laboratoire d'Immunologie, CHU Nantes, 44000 Nantes, France, 3Clinique de Chirurgie Digestive et Endocrinienne, Institut des Maladies de l'Appareil Digestif (IMAD), CHU Nantes, 44000 Nantes, France, 4CRCINA, INSERM, Université d'Angers, Université de Nantes, 44000 Nantes, France, 5Institut des Maladies de l’Appareil Digestif (IMAD), CHU Nantes, 44000 Nantes, France, 6UMR 1235, Neuropathies entériques et pathologies digestives, Université de Nantes, 44000 Nantes, France

P090: Exposure to high fat diet early in life impacts colitis severity in adult mice

ECCO '19 Copenhagen

Year: 2019
Authors:

Z. Al Nabhani*1, S. Dulauroy1, E. Lécuyer1, G. Eberl1

1Insitut Pasteur, Immunology, Paris, France

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