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P047: Deconditioning in quiescent Crohn’s Disease patients with heightened fatigue perceptionECCO'24
Year: 2024
Authors: McGing, J.J.(1);Nicholas, R.(2);Serres, S.(3);Gupta, A.(1);Radford, S.J.(1);Bradley, C.(2);Bawden, S.(2);Francis, S.T.(2);Greenhaff, P.L.(3);Moran, G.(1)*;
(1)University of Nottingham, School of Medicine, Nottingham, United Kingdom;(2)University of Nottingham, Sir Peter Mansfield Imaging Centre, Nottingham, United Kingdom;(3)University of Nottingham, School of Life Sciences, Nottingham, United Kingdom;
P048: Identification of IL36RN missense mutations in Crohn’s disease patients as a potentially new drug target for treating rare patients with over-activation of the IL36 signaling cascadeECCO'24
Year: 2024
Authors: Hecker, J.(1)*;Saurenbach, J.(1);Letizia, M.(1);TRR241 IBDome Consortium, T.(1);Löscher, B.S.(2);Franke, A.(2);Koop, K.(3);Neufert, C.(3);Schütz, A.(4);Siegmund, B.(1);Weidinger, C.(1);
(1)Charité – Universitätsmedizin Berlin- corporate member of Freie Universität Berlin and Humboldt -Universität zu Berlin, Department of Gastroenterology- Infectious Diseases and Rheumatology, Berlin, Germany;(2)Christian-Albrechts-University of Kiel, Institute of Clinical Molecular Biology, Kiel, Germany;(3)University Hospital Erlangen- Friedrich-Alexander University Erlangen-Nürnberg, Department of Medicine 1, Erlangen, Germany;(4)Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Gemeinschaft MDC, Berlin-Germany, Berlin, Germany;
P049: The lipidome of creeping fat in Crohn’s disease points towards a harmful microenvironmentECCO'24
Year: 2024
Authors: VerstocktMSc. PhD, S.(1)*;Dehairs, J.(2);Vanderhoydonc, F.(2);Ke, B.J.(1);De Greef, I.(1);Sabino, J.(3);Ferrante, M.(3);Bislenghi, G.(4);D’Hoore, A.(4);Swinnen, J.(2);Verstockt, B.(3);Vermeire, S.(3);
(1)KU Leuven, Department of Chronic Diseases and Metabolism CHROMETA, Leuven, Belgium;(2)KU Leuven, Department of Oncology, Leuven, Belgium;(3)University Hospitals Leuven, Department of Gastroenterology and Hepatology, Leuven, Belgium;(4)University Hospitals Leuven, Department of Abdominal Surgery, Leuven, Belgium;
P050: Paneth cell retinoid X receptor alpha drives metabolic gut inflammationECCO'24
Year: 2024
Authors: Meyer, M.(1)*;Grabherr, F.(1);Plattner, C.(2);Rieder, D.(2);Marteau, V.(2);Schwärzler, J.(1);Mayr, L.(1);Enrich, B.(1);Hilbe, R.(3);Jukic, A.(1);Grander, C.(1);Zollner, A.(1);Trajanoski, Z.(2);Tilg, H.(1);Adolph, T.E.(1);
(1)Medical University of Innsbruck, Department of Internal Medicine I- Gastroenterology- Hepatology- Endocrinology & Metabolism, Innsbruck, Austria;(2)Medical University of Innsbruck, Biocenter- Institute of Bioinformatics, Innsbruck, Austria;(3)Medical University of Innsbruck, Department of Internal Medicine II- Infectious Diseases- Immunology- Rheumatology- Pulmonology, Innsbruck, Austria;
P051: Diets enriched in fat and sugar and sex-dependant response to colitis in a mouse modelECCO'24
Year: 2024
Authors: Touly, N.(1)*;Arnone, D.(2);Caron, B.(3);Kökten, T.(4);Umoret, R.(4);Peyrin-Biroulet, L.(3);Boudaud, M.(2);
(1)IHU Infiny / CHRU de Nancy, IBD platform Clinical Research and Innovation Delegation, Nancy, France;(2)IHU Infiny, NGERE Nutrition Genetics and Exposure to Environmental Risks- INSERM- University of Lorraine, Nancy, France;(3)IHU Infiny / CHRU de Nancy, Gastroenterology, Nancy, France;(4)Inserm, NGERE Nutrition Genetics and Exposure to Environmental Risks- INSERM- University of Lorraine, Nancy, France;
P052: Mucosal IgG-like naive B-cell expansion and maturation contribute to ulcerative colitis pathogenesisECCO'24
Year: 2024
Authors: Fung, I.(1)*;Koelink, P.J.(1);Li Yim, A.Y.F.(1);Mulders, L.G.M.(2);Admiraal, I.(1);Verseijden, C.(1);Verhoeff, J.(1);Patel, A.(3);Wildenberg, M.E.(1);Luo, Y.(4);D’Haens, G.R.(2);de Jonge, W.J.(1);
(1)Amsterdam UMC location University of Amsterdam, Tytgat Institute for Liver and Intestinal Research, Amsterdam, The Netherlands;(2)Amsterdam UMC location University of Amsterdam, Gastroenterology and Hepatology, Amsterdam, The Netherlands;(3)Bristol-Myers Squibb, Global clinical development, San Diego, United States;(4)Bristol-Myers Squibb, Translational Medicine, New Jersey, United States;
P053: Pro-resolution Pathway in Experimental Colitis – A New Possible Therapeutic Approach for Inflammatory Bowel DiseasesECCO'24
Year: 2024
Authors: Chaim , F.H.M.(1);Pascoal , L.B.(1)*;Palma , B.B.(1);Rodrigues , B.L.(1);Castro , M.M.(1);Fagundes , J.J.(1);Milanski , M.(2);Lopes , L.R.(1);Velloso , L.A.(3);Leal , R.F.(1);
(1)Inflammatory Bowel Disease Research Laboratory- Gastrocenter- Colorectal Surgery Unit- School of Medical Sciences- University of Campinas Unicamp, Department of Surgery, Campinas, Brazil;(2)Laboratory of Metabolic Disorders- School of Applied Sciences- University of Campinas Unicamp, Department of Nutrition, Limeira, Brazil;(3)Laboratory of Cell Signaling- Obesity and Comorbidities Research Center- School of Medical Sciences- University of Campinas Unicamp, Department of Internal Medicine, Campinas, Brazil;
P054: R. intestinalis improves inflammatory bowel disease by preventing gut uric acid absorption through inhibiting METTL3 mediated m6A modification of SLC2A9ECCO'24
Year: 2024
Authors: Nie, K.(1)*;
(1)The Third Xiangya Hospital of Central South University, Gastroenterology, Changsha, China;
P055: GPR43 and GPR84 play a crucial role in supporting perianal fistula formation and disease progression in Crohn’s DiseaseECCO'24
Year: 2024
Authors: Rubbino, F.(1)*;Di Cristofaro, A.(1);Wozny, M.(2);Rizzo, G.(3);Pineda Chavez, S.E.(4);Converso, G.(2);Heijink, M.(5);Giera, M.(5);Maroli, A.(6); Bezzio, C.(6);Loy, L.(6);Carvello, M.(7);Spinelli, A.(7);Laghi, L.(8);Repici, A.(9);Armuzzi, A.(6);Vetrano, S.(10);
(1)IRCCS Humanitas Research Hospital, Laboratory of Molecular Gastroenterology, Rozzano Mi, Italy;(2)Humanitas University, Department of Biomedical Sciences, Rozzano Mi, Italy;(3)IRCCS Humanitas Research Hospital, Laboratory of Gastrointestinal Immunopathology, Rozzano Mi, Italy;(4)Humanitas University, Department of Biomedical Science, Rozzano Mi, Italy;(5)Leiden University Medical Center, Center of proteomics and metabolomics, Leiden, The Netherlands;(6)IRCCS Humanitas Research Hospital, Department of Gastroenterology, Rozzano Mi, Italy;(7)IRCCS Humanitas Research Hospital, Colorectal and IBD Surgery Unit- Department of Surgery, Rozzano Mi, Italy;(8)Azienda Universitario Ospedaliera di Parma, Facoltà di medicina e chirurgia, Parma, Italy;(9)IRCCS Humanitas Research Hospital, Department of Gastroenterology and Endoscopy, Rozzano Mi, Italy;(10)Humanitas University, Department of Biomedical Sciences, Pieve Emanuele Mi, Italy;
P056: Cereal intake and diet-related microbial metabolites in faeces associate with recurrence of gut inflammation during food reintroduction in children with Crohn’s disease treated with exclusive enteral nutrition; iPENS a multicentre, prospective study.ECCO'24
Year: 2024
Authors: Gkikas, K.(1)*;Lima, M.(1);McKirdy, S.(1);Gervais, L.(2);Smith, G.(3);Kerbiriou, C.(1);Nichols, B.(1);Zille, F.(1);Armstrong, L.(4);Jordan, T.(3);Chalmers, I.(5,6);Barlow, H.(7);Al Hourani, G.(8);Muhammed, R.(9);Wands, D.(2);Narula, P.(10);Patel, M.(11);Ijaz, U.Z.(12);Milling, S.(13);Gasparetto, M.(14);Henderson, P.(15);Wilson, D.C.(15);Hansen, R.(2,16);Russell, R.K.(15);Gerasimidis, K.(1);
(1)University of Glasgow, School of Medicine- Dentistry and Nursing, Glasgow, United Kingdom;(2)Royal Hospital for Children, Department of Paediatric Gastroenterology- Hepatology and Nutrition, Glasgow, United Kingdom;(3)University Hospital Wishaw, Department of Paediatrics, Wishaw, United Kingdom;(4)University Crosshouse Hospital, Department of Paediatrics, Crosshouse, United Kingdom;(5)Royal Aberdeen Children@E@s Hospital, Department of Paediatric Gastroenterology, Aberden, United Kingdom;(6)Tayside Children@E@s Hospital, Department of Paediatric Gastroenterology, Dundee, United Kingdom;(7)Royal Manchester Children@E@s Hospital, Department of Paediatrics, Manchester, United Kingdom;(8)Forth Valley Royal Hospital, Department of Paediatrics, Larbert, United Kingdom;(9)Birmingham Women@E@s and Children@E@s Hospital, Department of Paediatric Gastroenterology, Birmingham, United Kingdom;(10)Sheffield Children@E@s Hospital, Department of Paediatric Gastroenterology, Sheffield, United Kingdom;(11)Royal London Children@E@s Hospital, Department of Paediatric Gastroenterology, London, United Kingdom;(12)University of Glasgow, James Watt School of Engineering-, Glasgow, United Kingdom;(13)University of Glasgow, School of Infection and Immunity, Glasgow, United Kingdom;(14)Norfolk and Norwich University Hospitals, Department of Paediatric Gastroenterology, Norwich, United Kingdom;(15)Royal Hospital for Children and Young People, Department of Paediatric Gastroenterology- Hepatology and Nutrition, Edinburgh, United Kingdom;(16)University of Dundee, Department of Child health- Division of Clinical and Molecular Medicine- School of Medicine, Dundee, United Kingdom;
P057: Caudovirales may trigger molecular mimicry mechanisms in Crohn’s DiseaseECCO'24
Year: 2024
Authors: Errico, C.(1)*;Massimino, L.(1,2);Facoetti, A.(1);Nicolò, S.(1);Cagliani, S.(1);Spanò , S.(1,2);Parigi, T.L.(1,2);Riva, M.(1);Danese, S.(1,2);Ungaro, F.(1,2);
(1)San Raffaele Scientific Institute, Division of Immunology Transplantation and Infectious Diseases - Experimental Gastroenterology Laboratory, Milan, Italy;(2)San Raffaele Hospital, Gastro Center - Gastroenterology and Digestive Endoscopy, Milan, Italy;
P058: The identification of three linear epitopes on infliximab all map to complementarity-determining regionsECCO'24
Year: 2024
Authors: Tun, G.(1)*;Ramage, W.(2);Hufton, S.E.(2);Lobo , A.J.(1);
(1)Sheffield Teaching Hospitals NHS Foundation Trust, Gastroenterology, Sheffield, United Kingdom;(2)Medicines and Healthcare products Regulatory Agency, Biotherapeutics and Advanced Therapies- Research and Development, South Mimms, United Kingdom;
P059: GSDMB triggers intestinal inflammation via regulating BHLHA15-mediated hyperactive unfolded protein responseECCO'24
Year: 2024
Authors: Gong, W.(1)*;Zhao, W.(2);
(1)The First Affiliated Hospital of Xi@E@an Jiaotong University, Department of Gastrointestinal Surgery, Xi@E@an, China;(2)The First Affiliated Hospital of Xi@E@an Jiaotong University, Department of General Surgery, Xi@E@an, China;
P060: Increased metabolic activity of faecal Sutterella Wadsworthensis at IBD onset is associated with an increased risk of escalation to biologic therapies - Results from the Birimingham Inception Cohort StudyECCO'24
Year: 2024
Authors: Rimmer, P.(1)*;Cheesbrough, J.(1);Horniblow, R.(2);Tull, S.(3);Sharma, N.(1);Cooney, R.(1);Beggs, A.(4);Regan-Komito, D.(5);Iqbal, A.(3);Iqbal, T.(1);Quraishi, M.N.(1);
(1)University Hospitals Birmingham NHS Foundation Trust, Gastroenterology, Birmingham, United Kingdom;(2)University of Birmingham, Institute of Immunology and Infection, Birmingham, United Kingdom;(3)University of Birmingham, Institute of Cardiovascular Sciences, Birmingham, United Kingdom;(4)University of Birmingham, Institute of Cancer and Genomic Science, Birmingham, United Kingdom;(5)F. Hoffman-La Roche, Immunology- Infectious Diseases and Ophthalmology, Basel, Switzerland;
P061: The macrophage-specific role of PTPN23 in Acute and Chronic ColitisECCO'24
Year: 2024
Authors: Linzmeier, L.(1)*;Matus, V.(1);Determann , M.(1);Wilmink, M.(1);Schwarzfischer, M.(1);Sanchez Alvarez, R.(1);Pöhlmann, D.(1);Scharl, M.(1);Spalinger, M.(1);
(1)University Hospital Zurich, Gastroenterology and Hepatology, Zurich, Switzerland;
P062: Characterization of UC1 and UC2 patients: towards personalized medicine in Ulcerative ColitisECCO'24
Year: 2024
Authors: Castillo, F.(1)*;Selin, K.(2);Fransson , J.(2);Sorini, C.(3);Hedin, C.(1,4);Villablanca, E.(2,5);
(1)Karolinska Institutet, Department of Medicine Solna, Stockholm, Sweden;(2)Karolinska Institutet, Division of immunology and Allergy- Department of Medicine- Solna, Stockholm, Sweden;(3)Karolinska Institutet, Department of Clinical Neuroscience, Stockholm, Sweden;(4)Karolinska University Hospital, Gastroenterology unit- Department of Gastroenterology- Dermatovenereology and Rheumatology, Stockholm, Sweden;(5)Karolinska Institutet, Center of Molecular Medicine, Stockholm, Sweden;
P063: Interleukin-8 mucosal transcript as predictor of response to Vedolizumab treatment in Ulcerative Colitis: preliminary results from a prospective studyECCO'24
Year: 2024
Authors: Bota, A.D.(1)*;Mușa, A.M.(1);Dinu, M.C.(1);Săftoiu, A.(1);Mușa, M.(1);Coman, S.(1);Dobre, M.(2);Milanesi, E.(2);Țieranu, C.G.(1);
(1)@D@Elias@D@ Emergency University Hospital, Gastroenterology, Bucharest, Romania;(2)@D@Victor Babeș@D@ National Institute of Pathology, Molecular Pathology, Bucharest, Romania;
P064: Investigating the genotoxic effect of reduced glutathione, n-acetylcysteine, human umbilical cord-derived mesenchymal stem cell exosomes and let-7 miRNA mimics in human lymphocytes and EpiIntestinal cellsECCO'24
Year: 2024
Authors: Adoul, Z.(1)*;Jafarinejed, S.(1);Baumgartner, A.(2);Isreb, M.(3);Liu, F.(4);Anderson, D.(1);Najafzadeh, M.(1);
(1)University of Bradford, School of Chemistry and Biosciences, Bradford, United Kingdom;(2)York St John University, School of Science- Technology and Health, York, United Kingdom;(3)University of Bradford, School of Pharmacy and Medical Sciences, Bradford, United Kingdom;(4)The Scottish Association for Marine Science, Ecotoxicology Group, Oban, United Kingdom;
P065: The evolution of inflammatory bowel disease can be monitored through multi-omics characterization of gut tissuesECCO'24
Year: 2024
Authors: Tout, I.(1)*;Toufiq, M.(2);Missous, G.N.(3);Chin-Smith, E.(1);Mathew, R.(4);Tomei, S.(4);Ibrahim, N.(5);Abunahia, N.S.(6);Mifsud, W.(7);Charles, A.(7);Ammar, A.(8);Al Kaabi, S.(6);Van Panhuys, N.(3);Al-Mohannadi, M.J.(6);Mamoun, E.(5);Maccalli, C.(1);
(1)Sidra Medicine, Laboratory of Immune and Biological Therapy, Doha, Qatar;(2)Sidra Medicine, System Biology, Doha, Qatar;(3)Sidra Medicine, Laboratory of Immunoregulation, Doha, Qatar;(4)Sidra Medicine, Omics core, Doha, Qatar;(5)Sidra Medicine, Department of Gastroenterology- Hepatology and Nutrition, Doha, Qatar;(6)Hamad Medical Corporation, Department of Gastroenterology- Ambulatory Care Center, Doha, Qatar;(7)Sidra Medicine, Anatomical Pathology, Doha, Qatar;(8)Hamad Medical Corporation, Pathology, Doha, Qatar;
P066: Serum amyloid A – A Novel Biomarker of Ulcerative Colitis Disease ActivityECCO'24
Year: 2024
Authors: McShane, C.(1)*;O@E@Connell, F.(2);Corcoran, R.(3);Buckley, C.(2);Lynam-Lennon, N.(2);Kevans, D.(3);O@E@Sullivan, J.(2);
(1)St James@E@s Hospital, Department of Gastroenterology, Dublin, Ireland;(2)St. James’s Hospital and Trinity College Dublin, Department of Surgery- Trinity St. James’s Cancer Institute and Trinity Translational Medicine Institute, Dublin, Ireland;(3)St. James’s Hospital, Department of Gastroenterology, Dublin, Ireland;