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P057 IL-17 regulates expression of chemotactic chemokines in human colonic subepithelial myofibroblasts

ECCO'20 Vienna

Year: 2020
Authors:

E. Filidou1, G. Tarapatzi1, M. Boulkou2, K. Arvanitidis1, S. Vradelis3, V. Valatas2, G. Bamias4, G. Kolios1, I. Koutroubakis2, I. Drygiannakis2

1Laboratory of Pharmacology, Department of Medicine, Democritus University of Thrace, Alexandroupolis, Greece, 2Laboratory of Gastroenterology, Department of Medicine, University of Crete, Heraklion, Greece, 3University Hospital of Alexandroupolis, Democritus University of Thrace, Alexandroupolis, Greece, 4GI Unit, 3rd Academic Department of Internal Medicine, National and Kapodistrian University of Athens, Athens, Greece

P058 The lived experience of family planning of female patients diagnosed with inflammatory bowel disease and their partners during key reproductive stages: a qualitative study

ECCO'20 Vienna

Year: 2020
Authors:

W. Czuber-Dochan1, R. Homer2, M. Brookes3, C. Selinger4, S. Purewal5, S. Chapman6, H. Steed3

1King’s College London, Florence Nightingale Faculty of Nursing- Midwifery and Palliative Care, London, UK, 2University of Wolverhampton, Research Department, Wolverhampton, UK, 3The Royal Wolverhampton NHS Trust, Gastroenterology, Wolverhampton, UK, 4Leeds Teaching Hospital NHS Trust, Gastroenterology, Leeds, UK, 5Wolverhampton University, Psychology, Wolverhampton, UK, 6Bath University, Psychology, Bath, UK

P059 Cytokine responsive transcriptional networks in inflammatory bowel disease

ECCO'20 Vienna

Year: 2020
Authors:

A. Treveil1,2, P. Pavlidis3, A. Tsakmaki4, G. Bewick4, T. Korcsmaros1,2, N. Powell3,4,5

1Earlham Institute, Ecosystems and organisms, Norwich, UK, 2Quadram Institute, Gut Microbes and Health, Norwich, UK, 3Kings College London, Centre for Inflammation and Cancer Immunology, London, UK, 4Kings College London, Diabetes Research Group, School of Life Course Sciences, Faculty of Life Science and Medicine, London, UK, 5Imperial College London, Department of Metabolism, Digestion and Reproduction, London, UK

P060 The pharmacologic inhibition of store-operated calcium entry pathway in inflammatory bowel disease

ECCO'20 Vienna

Year: 2020
Authors:

M. Letizia1, C. Yerinde1, A. Sand1, S. Schlickeiser2, U. Kaufmann3, B. Siegmund1, S. Feske3, C. Weidinger1

1IBDome-DE Investigators, 1Charité Universitätsmedizin Berlin, Medical Department, Division of Gastroenterology, Infectiology and Rheumatology, Berlin, Germany, 2Charité Universitätsmedizin Berlin, Berlin-Brandenburg Center for Regenerative Therapies, Berlin, Germany, Berlin, Germany, 3New York University School of Medicine, Department of Pathology, New York, NY 10016, New York, USA

P061 The molecular landscape of perianal fistula in Crohn’s disease: opportunities for new therapeutic approaches

ECCO'20 Vienna

Year: 2020
Authors:

G. Bislenghi1, B. Verstockt2, J. Sabino2, C. Caenepeel3, S. Verstockt3, A. Wolthuis1, M. Ferrante2, A. D’Hoore1, S. Vermeire2, IBD Leuven

1University Hospitals Leuven, Department of Abdominal Surgery, Leuven, Belgium, 2University Hospitals Leuven, Department of Gastroenterology and Hepatology, Leuven, Belgium, 3KU Leuven, CHROMETA – Translational Research in Gastrointestinal Disorders, Leuven, Belgium

P062 Dose-dependent differential effects of vedolizumab therapy on adhesion of regulatory and effector T cells

ECCO'20 Vienna

Year: 2020
Authors:

E. Becker, M. Wiendl, A. Schulz-Kuhnt, I. Atreya, R. Atreya, M. Neurath, S. Zundler

University of Erlangen-Nuremberg, Department of Medicine 1, Kussmaul Campus for Medical Research and Translational Research Center, Erlangen, Germany

P063 B-cell receptor signalling in lymphoid tissues may be regulated by CEACAM1

ECCO'20 Vienna

Year: 2020
Authors:

T. Nagaishi, N. Tsugawa, D. Yamada, T. Watabe, M. Onizawa, M. Watanabe

Tokyo Medical and Dental University, Gastroenterology, Tokyo, Japan

P064 Exosomes from mesenchymal stromal cells reduce murine colonic inflammation via a macrophage-dependent mechanism

ECCO'20 Vienna

Year: 2020
Authors:

X.R. Wu1, P. Lan1, X.J. Wu1, X. Gao2

1The Sixth Affiliated Hospital of Sun Yat-sen University, Department of Colorectal Surgery, Guangzhou, China, 2The Sixth Affiliated Hospital of Sun Yat-sen University, Department of Gastroenterology, Guangdong, China

P065 Metabolic utilisation of propanediol by adherent-invasive E. coli regulates intestinal tissue immunity

ECCO'20 Vienna

Year: 2020
Authors:

M. Viladomiu1, M. Metz1, S. Lima1, C.J. Guo1, K. Simpson2, E. Scherl1, R. Longman1

1Weill Cornell Medicine, Medicine, New York, USA, 2Cornell University, Veterinary Medicine, Ithaca, USA

P066 Azathioprine linked with impaired intestinal epithelial regeneration in Crohn’s disease

ECCO'20 Vienna

Year: 2020
Authors:

K. Borycka-Kiciak1, A. Pietrzak2,3, K. Ferenc4, P. Pietrzak4,5, L. Janaszek1, W. Tarnowski1, R. Zabielski4

1Orlowski Hospital, CPME, Department of General, Oncological and Gastrointestinal Surgery, Warsaw, Poland, 2Centre of Postgraduate Medical Education, Department of Gastroenterology, Hepatology and Clinical Oncology, Warsaw, Poland, 3Institute of Oncology, Department of Oncological Gastroenterology, Warsaw, Poland, 4Warsaw University of Life Sciences, Department of Large Animal Diseases with the Clinic, Faculty of Veterinary Medicine, Warsaw, Poland, 5Warsaw Agricultural University, Department of Physiological Sciences, Warsaw, Poland

P067 Proteins citrullination and Crohn’s disease: PAD4 but not PAD2 is a strong marker of ileal inflammation

ECCO'20 Vienna

Year: 2020
Authors:

G. Dragoni1,2, B. Creyns2,3, G. De Hertogh4, B. Verstockt2,5, W.J. Wollants2, B.J. Ke2, L. Marcellis4, G. Matteoli2, A. D’Hoore6, A. Galli1, M. Ferrante2,5, S. Vermeire2,5

1University of Florence, Clinical Gastroenterology Unit- Department of Biomedical Clinical and Experimental Sciences ‘Mario Serio’, Firenze, Italy, 2KU Leuven, Department of Chronic Diseases, Metabolism and Ageing, Translational Research Center for Gastrointestinal Disorders TARGID, Leuven, Belgium, 3KU Leuven, Department of Microbiology, Immunology and Transplantation, Allergy and Clinical Immunology Research Group, Leuven, Belgium, 4KU Leuven, Department of Imaging and Pathology, Translational Cell and Tissue Research, Leuven, Belgium, 5University Hospitals Leuven, Department of Gastroenterology and Hepatology, Leuven, Belgium, 6University Hospitals Leuven, Department of Abdominal Surgical Oncology, Leuven, Belgium

P068 Erythrocyte and reticulocyte parameters in children with inflammatory bowel diseases

ECCO'20 Vienna

Year: 2020
Authors:

E. Semikina1, A. Potapov2, V. Tsvetkova2, A. Anoushenko2, S. Akulova1

1National Medical Research Center for Children’s Health of the Ministry of Health of the Russian Federation, Central clinical laboratory, Moscow, Russian Federation, 2National Medical Research Center for Children’s Health of the Ministry of Health of the Russian Federation, Gastroenterology Department with Hepatology Group, Moscow, Russian Federation

P069 CD73 promotes colitis-associated tumourigenesis in mice

ECCO'20 Vienna

Year: 2020
Authors:

X. Wu, X. Liu, N. Lan, X. Zheng, Y. Chen, Z. Cai, P. Lan, X. Wu

The Sixth Affiliated Hospital, Sun Yat-sen University, Department of Colorectal Surgery, Guangzhou, China

P070 Machine learning approaches to identify IBD biomarkers from longitudinal microbiome data

ECCO'20 Vienna

Year: 2020
Authors:

M. Madgwick1,2, P. Sudhakar1,2,3, N.S. Tabib3, P. Norvaisas4, P. Creed4, B. Verstockt3,5, S. Vermeire3,5, T. Korcsmáros1,2

1Earlham Institute, Organisms and Ecosystems, Norwich, UK, 2Quadram Institute, Gut Microbes and Health, Norwich, UK, 3KU Leuven, Department of Chronic Diseases, Metabolism and Ageing, Translational Research Center for Gastrointestinal Disorders TARGID, Leuven, Belgium, 4BenevolentAI, Precision Medicine Team, London, UK, 5University Hospitals Leuven, Department of Gastroenterology and Hepatology, Leuven, Belgium

P071 Studying the effects of the probiotic bifidobacteria on gut health and intestinal epithelial cells function

ECCO'20 Vienna

Year: 2020
Authors:

M. Poletti1, I. Hautefort1, A. Treveil1,2, A. Demeter1, E. Rodriguez1, A. Brion2, A. Goldson2, D. Divekar3, Z. Schofield2, I. O’Neill2, A. Lister1, J. Lipscombe1, A. Watson3,4, I. Macaulay1, L. Hall2, T. Korcsmaros1,2

1Earlham Institute, Organisms and Ecosystems, Norwich, UK, 2Quadram Institute Biosciences, Gut microbes and Health, Norwich, UK, 3University of East Anglia, Norwich Medical School, Norwich, UK, 4University of East Anglia, School of Biological Sciences, Norwich, UK

P072 Evaluation of dosing strategies of anti-TNFα monoclonal antibodies using pharmacokinetic modelling and simulation

ECCO'20 Vienna

Year: 2020
Authors:

A. Démaris1,2, A.M. Grišić1,2, W. Huisinga3, R. Walter4, C. Kloft1

1Freie Universität Berlin, Department of Clinical Pharmacy and Biochemistry, Berlin, Germany, 2PharMetrx, Graduate Research Training Program, Berlin, Germany, 3Universität Potsdam, Institute of Mathematics, Potsdam, Germany, 4Medical University of Vienna, Department for Gastroenterology and Hepatology, Vienna, Austria

P073 Compartmentalised human gut immunity: studies of innate and adaptive lymphocyte distribution in the epithelium, lamina propria and GALT of healthy gut mucosa by flow cytometry

ECCO'20 Vienna

Year: 2020
Authors:

A. Carrasco Garcia1,2, A. Rao1, E. Kokkinou1, S. Haapaniemi2,3, U. Lindforss4, M.E. Winberg2, M. Casado-Bedmar2, T. Fenton5, P. Jørgensen5, C. Nordenvall4, W. Agace5, Å.V. Keita2, J.D. Söderholm2,6, J. Mjösberg1,2

1Karolinska Institutet, Center for Infectious Medicine, Stockholm, Sweden, 2Linköping University, Department of Clinical and Experimental Medicine, Linköping, Sweden, 3Linköping University, Department of Surgery, Norrköping, Sweden, 4Karolinska Institutet and Karolinska University Hospital, Department of Molecular Medicine and Surgery, Stockholm, Sweden, 5Technical University of Denmark, Department of Health Technology, Lyngby, Denmark, 6Linköping University, Department of Surgery, Linköping, Sweden

P074 Histopathologic evaluation and lymphocyte subpopulations of the upper digestive tract of Crohn’s disease

ECCO'20 Vienna

Year: 2020
Authors:

A. Martin Cardona1,2, A. Carrasco García1,2, E. Tristán Lopez3, Y. Zabana Abdo1,2, M. Aceituno Quintanilla1,2, C. Ferrer Cassadó4, D. Horta Sangenis1, L. Ruiz-Campos1, C. Loras Alastruey1,2, X. Andujar Murcia1,2, O. Benítez Leiva1, F. Fernández-Bañares1,2, M. Esteve Comas1,2

1Hospital Universitari Mútua Terrassa, Digestive Diseases Department, Terrassa, Spain, 2Centro de Investigación biomédica en red de enfermedades hepáticas y digestivas CIBERehd, Terrassa, Barcelona, Spain, 3Hospital Universitari Mútua Terrassa, Laboratori de Recerca. Fundació Mútua de Terrassa, Terrassa, Spain, 4Hospital Universitari Mútua Terrassa, Department of Pathology, Terrassa, Spain

P075 Muc5ac expression protects the colonic barrier in experimental colitis

ECCO'20 Vienna

Year: 2020
Authors:

L. O’Connell1, K. Olli2, C. Rapp2, C. Collins1, E. McNamee3, O. Jensen2, P. Jedlicka4, K. Allison2, M. Goldberg5, M. Gerich5, C. Evans6, C. AHERNE1,2

1University College Dublin, School of Medicine, Dublin 4, Ireland, 2University of Colorado Denver, Anesthesiology, Aurora, USA, 3Maynooth University, Biology, Maynooth, Ireland, 4University of Colorado Denver, Pathology, Aurora, USA, 5University of Colorado Denver, Gastroenterology, Aurora, USA, 6University of Colorado Denver, Pulmonary medicine and critical care, Aurora, USA

P076 Role of gut microbiota in mediating the effects of thiopurines

ECCO'20 Vienna

Year: 2020
Authors:

M. Franzin1, M. Lucafò2, C. Lagatolla3, G. Stocco3, G. Decorti4

1PhD Course in Reproductive and Developmental Sciences, University of Trieste, Department of Medical, Surgical and Health Sciences, Trieste, Italy, 2IRCCS Burlo Garofolo, Advanced Translational Diagnostics Laboratory, Trieste, Italy, 3University of Trieste, Department of Life Sciences, Trieste, Italy, 4University of Trieste, Department of Medicine, Surgery and Health Sciences, Trieste, Italy