P0170: The presence of creeping fat in a TNBS-induced colitis model is associated with greater acute inflammation and bacterial translocation.ECCO'25Year: 2025
Authors: Suau, R.(1)*;Clua, L.(1);Guasch, M.(2);Monfort-Ferré, D.(3);Boronat-Toscano, A.(3);Aquino, M.E.(4);Matute, K.S.(4);Cabrer, M.(1);Calafat, M.(1,5,6);Mañosa, M.(1,5,6);Domènech, E.(1,5,6);Jimeno, M.(4);Serena, C.(3);Bartolí, R.(6,7);Manyé, J.(1,6);
(1)Germans Trias i Pujol Research Institute IGTP, Inflammatory Bowel Diseases Research Group, Badalona, Spain;(2)Parc Sanitari Sant Joan de Déu Hospital, Department of Surgery, Sant Boi del Llobregat, Spain;(3)Joan XXIII University Hospital- Pere Virgili Health Research Institute, Inflammatory Bowel Disease Research Group, Tarragona, Spain;(4)Hospital Universitari Germans Trias i Pujol HUGTP, Pathology Department, Badalona, Spain;(5)Germans Trias i Pujol University Hospital HUGTP, Digestive System Service, Badalona, Spain;(6)Centro de Investigación Biomédica en Red, Enfermedades Hepáticas y Digestivas CIBEREHD, Madrid, Spain;(7)Germans Trias i Pujol Research Institute IGTP, Liver and Digestive Diseases, Badalona, Spain;
L Clua, R Suau, M Guasch, D Monfort-Ferré, I Vañó, C Serena, E Domènech, R Bartolí, J Manyé, P022 Development of a novel experimental model for studying creeping fat in Crohn's Disease, Journal of Crohn's and Colitis, Volume 18, Issue Supplement_1, January 2024, Pages i275–i276, https://doi.org/10.1093/ecco-jcc/jjad212.0152
P0171: IL-36 signaling as a drug target in Crohn’s disease patients with IL36RN mutationsECCO'25Year: 2025
Authors: Hecker, J.(1)*;Plattner, C.(2);Löscher, B.S.(3);Saurenbach, J.(1);Letizia, M.(1);Rieder, D.(2);Freise, I.(1);Koop, K.(4);Neufert, C.(4);Kunkel, D.(5);Schütz, A.(6);Becker , C.(4);Atreya, R.(4);Trajanoski, Z.(2);Franke, A.(3);Sonnenberg, E.(1);Siegmund, B.(1);Weidinger, C.(1);
(1)Charité - Universitätsmedizin Berlin- corporate member of Freie Universität Berlin- Humboldt-Universität zu Berlin- Campus Benjamin Franklin, Department of Gastroenterology- Infectious Diseases and Rheumatology, Berlin, Germany;(2)Institute of Bioinformatics- Medical University of Innsbruck, Biocenter, Innsbruck, Austria;(3)Kiel University and University Medical Center, Institute of Clinical Molecular Biology, Kiel, Germany;(4)Friedrich-Alexander-Universität Erlangen-Nürnberg, Department of Medicine 1, Erlangen, Germany;(5)Berlin Institute of Health at Charité- Universitätsmedizin Berlin, Flow & Mass Cytometry Core Facility, Berlin, Germany;(6)Max-Delbrück-Center for Molecular Medicine in the Helmholtz Association MDC, Department Protein Production and Characterization, Berlin, Germany; The TRR241 IBDome Consortium
P0172: In silico drug repurposing approach for the discovery of therapeutics for intestinal fibrosis in crohn’s diseaseECCO'25Year: 2025
Authors: Nikolakis, D.(1)*;Li Yim, A.Y.F.(2);Lartey, D.(3);Rieder, F.(4);D'Haens, G.R.(5);van de Sande, M.G.H.(6);Löwenberg, M.(5);
(1)Amsterdam UMC- University of Amsterdam, Department of Gastroenterology and Hepatology- Amsterdam Institute for Gastroenterology Endocrinology and Metabolism / Department of Rheumatology & Clinical Immunology- Amsterdam Institute for Infection & Immunity, Amsterdam, The Netherlands;(2)Amsterdam UMC- University of Amsterdam, Tytgat Institute for Liver and Intestinal Research, Amsterdam, The Netherlands;(3)Amsterdam UMC- University of Amsterdam, Department of Gastroenterology/ Tytgat Institute for Liver and Intestinal Research, Amsterdam, The Netherlands;(4)Digestive Disease Institute/ Lerner Research Institute, Department of Gastroenterology- Hepatology and Nutrition/ Department of Inflammation and Immunity/ Center for Global Translational Inflammatory Bowel Disease Research/ Cleveland Clinic, Cleveland- Ohio, United States;(5)Amsterdam UMC- University of Amsterdam, Department of Gastroenterology and Hepatology, Amsterdam, The Netherlands;(6)Amsterdam UMC- University of Amsterdam, Amsterdam Institute for Infection & Immunity/ Department of Rheumatology and Clinical Immunology/ Department of Experimental Immunology, Amsterdam, The Netherlands;
1. Bettenworth D, Bokemeyer A, Baker M, Mao R, Parker CE, Nguyen T, Ma C, Panés J, Rimola J, Fletcher JG, Jairath V, Feagan BG, Rieder F; Stenosis Therapy and Anti-Fibrotic Research (STAR) Consortium. Assessment of Crohn's disease-associated small bowel strictures and fibrosis on cross-sectional imaging: a systematic review. Gut. 2019 Jun;68(6):1115-1126. doi: 10.1136/gutjnl-2018-318081. Epub 2019 Apr 3. PMID: 30944110; PMCID: PMC6580870.
2. Mukherjee PK, Nguyen QT, Li J, Zhao S, Christensen SM, West GA, Chandra J, Gordon IO, Lin S, Wang J, Mao R, Czarnecki D, Rayan C, Goren I, Banerjee S, Kotak P, Plesec T, Lal S, Fabre T, Asano S, Bound K, Hart K, Park C, Martinez R, Dower K, Wynn TA, Hu S, Naydenov N, Decaris M, Turner S, Holubar SD, Steele SR, Fiocchi C, Ivanov AI, Kravarik KM, Rieder F. Stricturing Crohn's Disease Single-Cell RNA Sequencing Reveals Fibroblast Heterogeneity and Intercellular Interactions. Gastroenterology. 2023 Nov;165(5):1180-1196. doi: 10.1053/j.gastro.2023.07.014. Epub 2023 Jul 26. PMID: 37507073.
3. Keenan AB, Jenkins SL, Jagodnik KM, et al. (2018). The Library of Integrated Network-Based Cellular Signatures NIH Program: System-Level Cataloging of Human Cells Response to Perturbations. Cell Syst. 2018;6(1):13-24. doi:10.1016/j.cels.2017.11.001.
4. Lamb, Justin et al. (2006). The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease. Science (New York, N.Y.) vol. 313,5795: 1929-35. doi:10.1126/science.1132939.
P0173: The impact of dietary composition on metallothionein gene expression in the intestinal epithelium by exclusive enteral nutritionECCO'25Year: 2025
Authors: Curry, D.(1)*;Lemons, J.(2);Friedman, E.(1);Li, Y.(3);Hao, F.(4);Li, H.(3);Liu, L.(2);Patterson, A.(4);Henao-Mejia, J.(5); Lewis, J.(1);Wu, G.(1);
(1)Perelman School of Medicine- University of Pennsylvania, Division of Gastroenterology and Hepatology, Philadelphia- PA, United States;(2)USDA Eastern Regional Research Center, Dairy and Functional Foods Research Unit, Wyndmoor- PA, United States;(3)Perelman School of Medicine- University of Pennsylvania, Department of Biostatistics- Epidemiology and Informatics, Philadelphia- PA, United States;(4)Pennsylvania State University, Department of Veterinary and Biomedical Sciences, State College- PA, United States;(5)Perelman School of Medicine- University of Pennsylvania, Department of Pathology and Laboratory Medicine, Philadelphia- PA, United States;
P0174: Enteric glial cells-derived NGF prevents necroptosis of intestinal epithelial cells and alleviates DSS-induced colitisECCO'25Year: 2025
Authors: Min, Z.(1)*;Zhang, Y.(2);Hu, C.(2);Song, X.(2);Guo, H.(2);
(1)Chongqing General Hospital- Chongqing University Chongqing- China, Gastroenterology, Chongqing, China;(2)Chongqing General Hospital- Chongqing University- Chongqing- China, Gastroenterology, Chongqing, China;
P0175: A new blocker of endothelial dysfunction ameliorates colitis independently of IL-10 by regulating both barrier function and the recruitment of immune cellsECCO'25Year: 2025
Authors: Park, I.S.(1);Kim, J.H.(1);Kim, Y.W.(1);Kim, D.(2);Shin, Y.(1);Kim, K.B.(1);Kim, T.I.(1);KimResearch professor, S.W.(3)*;Kwon, Y.G.(4);Cheon, J.H.(1);
(1)Yonsei University College of Medicine, Internal Medicine and Institute of Gastroenterology- Graduate School of Medical Science- Brain Korea 21 Project, Seoul, Korea- Republic Of;(2)Curacle Co. Ltd, Bio Research, Seoul, Korea- Republic Of;(3)Yonsei University College of Medicine, Department of Internal Medicine and Institute of Gastroenterology, Seoul, Korea- Republic Of;(4)Curacle Co. Ltd, Curacle Co. Ltd, Seoul, Korea- Republic Of;
1. Kim, Y. S. et al. CU06-1004 Alleviates Experimental Colitis by Modulating Colonic Vessel Dysfunction. Front Pharmacol 11, 571266 (2020).
2. Katsandegwaza, B., Horsnell, W. & Smith, K. Inflammatory Bowel Disease: A Review of Pre-Clinical Murine Models of Human Disease. Int J Mol Sci 23 (2022).
3. Wei, H. X., Wang, B. & Li, B. IL-10 and IL-22 in Mucosal Immunity: Driving Protection and Pathology. Front Immunol 11, 1315 (2020).
4. Kang, S. et al. TRIM40 is a pathogenic driver of inflammatory bowel disease subverting intestinal barrier integrity. Nat Commun 14, 700 (2023).
5. Li, J. Y. et al. IRF/Type I IFN signaling serves as a valuable therapeutic target in the pathogenesis of inflammatory bowel disease. Int Immunopharmacol 92, 107350 (2021).
6. Heemskerk, N. et al. F-actin-rich contractile endothelial pores prevent vascular leakage during leukocyte diapedesis through local RhoA signalling. Nat Commun 7, 10493 (2016).
P0176: Single-cell RNA sequencing reveals the immunological mechanisms underlying Anti-saccharomyces cerevisiae antibody positivity in both non-inflamed and inflamed mucosal tissues of IBD patientsECCO'25Year: 2025
Authors: Im, H.W.(1)*;Kim, K.A.(2);Choi, S.(3);Joh, C.S.Y.(4);Im, J.P.(5);Kim, B.G.(5);Kim, J.S.(5);Kim, H.J.(4);Koh, S.J.(5);
(1)Seoul National University Hospital, Internal medicine, Seoul, Korea- Republic Of;(2)1Seoul National University Hospital-, Internal medicine, Seoul, Korea- Republic Of;(3)1Seoul National University Hospital, Internal medicine, Seoul, Korea- Republic Of;(4)Seoul National University Graduate School, Department of Biomedical Science, Seoul, Korea- Republic Of;(5)Seoul National University College of Medicine, Department of Internal Medicine and Liver Research Institute, Seoul, Korea- Republic Of;
P0177: Dietary prevention of undernutrition reduces intestinal inflammation in a DSS-induced model of colitis and is associated with anti-inflammatory metabolites-producing bacteria.ECCO'25Year: 2025
Authors: Leboutte, M.(1)*;Rebollo, E.(1);Pangault, C.(1);Ribet, D.(1);Guérin, C.(1);Bôle-Feysot, C.(1);Monnoye, M.(2);Gérard, P.(2);Savoye, G.(3);Marion-Letellier, R.(1);
(1)ADEN UMR1073- Nutrition- Inflammation and microbiota-gut-brain axis, UFR Santé- Université de Rouen Normandie, Rouen, France;(2)Micalis Institute- INRAE, AgroParisTech- Université Paris-Saclay, Jouy-en-Josas, France;(3)ADEN UMR1073- Nutrition- Inflammation and microbiota-gut-brain axis, CHU Rouen- Department of Gastroenterology, Rouen, France;
1. Bischoff, S. C. et al. ESPEN guideline on Clinical Nutrition in inflammatory bowel disease. Clin Nutr 42, 352–379 (2023).
P0178: Lack of DNA methyltransferase DNMT3A in fibroblasts impairs cell growth and wound healingECCO'25Year: 2025
Authors: Escudero-Hernández, C.(1)*;Hübner, E.(2);Núñez-Torvisco, S.(2);Rodríguez-Peña, A.(2);Montague, J.(2);Rosenstiel, P.(2);
(1)University Hospital Schleswig-Holstein, Institute of Clinical Molecular Biology IKMB, Kiel, Germany;(2)University Hospital Schleswig-Holstein and Christian-Albrechts-University Kiel, Institute of Clinical Molecular Biology IKMB, Kiel, Germany;
1. Hampe J, Franke A, Rosenstiel P, et al. A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1. Nat Genet. 2007;39(2):207-211. doi:10.1038/ng1954
2. Fazio A, Bordoni D, Kuiper JWP, et al. DNA methyltransferase 3A controls intestinal epithelial barrier function and regeneration in the colon. Nat Commun. 2022;13(1):6266. doi:10.1038/s41467-022-33844-2
P0179: Spatial immune profiling of Crohn's Disease fistula carcinomas - Defining a distinct cancer subtypeECCO'25Year: 2025
Authors: Lehmann, M.(1)*;Paclik, D.(1);Huck, A.(1);Arnold, A.(2);Kurth-Stavenhagen, C.(1);Vieth, M.(3);Treese, C.(1);Kühl, A.A.(4);Siegmund, B.(1);
(1)Charité - Universitätsmedizin Berlin- corporate member of Freie Universität Berlin- Humboldt-Universität zu Berlin- Campus Benjamin Franklin, Department of Gastroenterology- Infectious Diseases and Rheumatology, Berlin, Germany;(2)Charité - Universitätsmedizin Berlin, Institute of Pathology, Berlin, Germany;(3)Friedrich-Alexander-Unversität Erlangen-Nürnberg- Klinikum Bayreuth, Institute of Pathology, Bayreuth, Germany;(4)Charité - Universitätsmedizin Berlin- corporate member of Freie Universität Berlin- Humboldt-Universität zu Berlin- Campus Benjamin Franklin, iPATH.Berlin, Berlin, Germany; German IBD Study Group (GISG)
P0180: Bifidobacterium longum alleviates dextran sulfate sodium-induced colitis through the differential regulation of Toll-like receptor 5 on enteric glial cellsECCO'25Year: 2025
Authors: Zeng, Q.S.(1)*;Zou, M.(2);Gan, H.(3);
(1)The Second Affiliated Hospital- Chongqing Medical University, Department of Infectious Diseases, Chongqing, China;(2)Chongqing General Hospital, Department of Gastroenterology and the Center of Inflammatory Bowel Disease, Chongqing, China;(3)West China Hospital- Sichuan University, Department of Gastroenterology and the Center of Inflammatory Bowel Disease, Chengdu, China;
P0181: Modulating macrophage activity via NAAA pharmacological inhibition: a therapeutic strategy for intestinal fibrosisECCO'25Year: 2025
Authors: Nani, M.(1)*;De Cicco , P.(2);Cattaneo, F.(3);Petrosino, S.(4);Tropeano, F.P.(5);Miraglia, M.(2);Pagano, E.(2);Rinaldi, M.M.(2);Izzo, A.A.(2);Romano, B.(2);
(1)Federico II University, Department of Pharmacy, Naples, Italy;(2)University of Naples Federico II, Department of Pharmacy- School of Medicine and Surgery, Naples, Italy;(3)University of Naples Federico II, bDepartment of Molecular Medicine and Medical Biotechnology- School of Medicine and Surgery, Naples, Italy;(4)National Research Council, Institute of Biomolecular Chemistry, Pozzuoli, Italy;(5)University of Naples Federico II, Department of Clinical Medicine and Surgery- School of Medicine and Surgery-, Naples, Italy; Francesca Paola Tropeano
P0182: The systemic administration of the anti-MCL1, S63845, reduces inflammation and fibrosis in a murine model of DSS-Chronic ColitisECCO'25Year: 2025
Authors: Jarén, A.(1)*;Macías-Ceja, D.C.(1);Burgos, R.(1);Cosín-Roger, J.(1,2);Cejudo-Garcés, A.(1);Patel , J.(1);Ortiz-Masiá, D.(2,3,4);Calatayud, S.(1,2);Barrachina, M.D.(1,2);
(1)Universitat de València, Pharmacology Department, Valencia, Spain;(2)Centro de investigaciones en red CIBER, Enfermedades Hepáticas y Digestivas, Valencia, Spain;(3)Universitat de València, Medicine Department, Valencia, Spain;(4)Grupo español de trabajo en enfermedad de Crohn y Colitis GETECCU, Grupo de Investigación básica y traslacional, Madrid, Spain;
1.Seco-Cervera M et al Biochim Biophys Acta Mol Basis Dis. 2024 Feb;1870(2):166966BBA
P0184: Molecular signature of bowel urgency in Ulcerative ColitisECCO'25Year: 2025
Authors: Pakpoor, J.(1)*;Hosack , T.(1);Sharma, O.(2);Teague, R.(3);Matini, L.(2);Kormilitzin, A.(4);Hutton, K.(3);Walsh, A.(2);Friedrich, M.(2);Travis, S.(5);
(1)Kennedy Institute of Rheumatology, Nuffield Department of Orthopaedics- Rheumatology and Musculoskeletal Science, Oxford, United Kingdom;(2)Translational Gastroenterology and Liver Unit, Nuffield Department of Medicine, Oxford, United Kingdom;(3)Oxford Centre for Histopathology Research, Nuffield Department of Surgical Sciences, Oxford, United Kingdom;(4)Department of Psychiatry, Medical Sciences Division, Oxford, United Kingdom;(5)University of Oxford, Kennedy Institute, Oxford, United Kingdom;
1. Travis S, Potts Bleakman A, Dubinsky MC, et al. The Communicating Needs and Features of IBD Experiences (CONFIDE) Study: US and European patient and health care professional perceptions of the experience and impact of symptoms of moderate-to-severe ulcerative colitis. Inflamm Bowel Dis. 2024;30(6):939-949. doi:10.1093/ibd/izad142
2. Walsh A, Matini L, Hinds C, et al. Real-time data monitoring for ulcerative colitis: patient perception and qualitative analysis. Intest Res. 2019;17(3):365-374. doi: 10.5217/ir.2018.00173
P0186: The Significance of BACH2 Expression in Mesenteric Lymph Nodes of Crohn’s DiseaseECCO'25Year: 2025
Authors: Hasegawa, M.(1)*;Ogino, T.(1);Sekido, Y.(1);Takeda, M.(1);Hata, T.(1);Hamabe, A.(1);Miyoshi, N.(1);Uemura, M.(1);Mizushima, T.(2);Doki, Y.(1);Eguchi, H.(1);
(1)Osaka University, Department of Gastroenterological Surgery- Graduate School of Medicine, Suita city, Japan;(2)Dokkyo Medical University, Department of Colorectal Surgery, Shimotsuga gun, Japan;
P0189: Microbial and Molecular Profiling of the appendix of pediatric patients with inflammatory bowel diseasesECCO'25Year: 2025
Authors: Arjomand Fard, N.(1)*;Githaka, J.M.(2);Veniamin, S.(3);Guan, L.L.(4);Lerner, P.(5);Andrews, J.(6);Madsen, K.(3);Perry, T.(5);Wine, E.(7);
(1)University of Alberta, Department of Physiology, Edmonton, Canada;(2)University of Alberta, Department of Biochemistry, Edmonton, Canada;(3)University of Alberta, Department of Medicine, Edmonton, Canada;(4)University of British Columbia, Department of Functional Genomics & Animal Microbiome, Vancouver, Canada;(5)University of Alberta, Department of Surgery, Edmonton, Canada;(6)University of Alberta, Department of Laboratory Medicine & Pathology, Edmonton, Canada;(7)University of Alberta, Department of Pediatrics and Physiology, Edmonton, Canada;
1. Wine E. Should we be treating the bugs instead of cytokines and T cells? Dig Dis. 2014;32(4):403-9.
2. Isaac D, Wine E. Overview of Pediatric Crohn Disease. In: Kuipers E, editor. Encyclopedia of Gastroenterology. 2nd Edition ed. Oxford, UK: Academic Press; 2020. p. 754-60.
3. Arjomand Fard N, Armstrong H, Perry T, Wine E. Appendix and Ulcerative Colitis: a Key to Explaining the Pathogenesis and Directing Novel Therapies?. Inflammatory Bowel Diseases. 2023 Jan 1;29(1):151-60.
4. Felice C, Armuzzi A. Therapeutic Role of Appendectomy in Ulcerative Colitis: A Tangible Perspective? J Crohns Colitis. 2019;13(2):142-3.
P0190: Hypoglycemia induces SLC7A11-dependent disulfidptosis to regulate intestinal inflammation in IBDECCO'25Year: 2025
Authors: Chen, C.(1)*;Tao, M.(2);Fu, Y.(2);
(1)The First Affiliated Hospital of USTC-Division of Life Sciences and Medicine- University of Science and Technology of China, Department of Gastroenterology, Hefei, China;(2)Union Hospital- Tongji Medical College- Huazhong University of Science and Technology, Department of Gastroenterology, Wuhan, China;
1. Jung, J., et al. Metabolism as a guiding force for immunity. Nat. Cell Biol. 21, 85-93 (2019).
2. Liu, X., et al. Actin cytoskeleton vulnerability to disulfide stress mediates disulfidptosis. Nat. Cell Biol. 25, 404-414 (2023).