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P037 Antagonism of chemokine receptor CCR9 synergises with anti-TNFα immunotherapy to reduce inflammation in the MDR1a−/− mouse model of colitis

ECCO'20 Vienna

Year: 2020
Authors:

J. Campbell1, L. Ertl1, K. Ebsworth1, J. McMahon2, P. Zhang2, V. Chhina1, I. Charo1, T. Schall1

1Department of Biology, ChemoCentryx, Inc., Mountain View, CA, USA, 2Department of Chemistry, ChemoCentryx, Inc., Mountain View, CA, USA

P038 A single-cell transcriptomics approach reveals high-resolution cellular signatures in Crohn’s disease

ECCO'20 Vienna

Year: 2020
Authors:

A. Garrido Trigo1, A.M. Corraliza1, M. Veny1, J. Lozano2, E. Ricart3, I. Ordás3, M.C. Masamunt3, J. Panés3, M. Hemberg4, A. Salas1

1IDIBAPS, Inflammatory Bowel Disease Unit, Barcelona, Spain, 2Ciberehd, Bioinformatics, Barcelona, Spain, 3Hospital Clinic de Barcelona, Gastroenterology, Barcelona, Spain, 4Wellcome Trust Sanger Institute, Bioinformatics, Hinxton, UK

P039 Regional distribution of TCR Vδ1 and TCR Vδ2 cells in healthy and inflamed mucosa of inflammatory bowel disease

ECCO'20 Vienna

Year: 2020
Authors:

E. Tristan, A. Carrasco, A. Martín-Cardona, Y. Zabana, M. Aceituno, D. Horta, X. Andújar, I. Salvador, C. Loras, F. Fernández-Bañares, M. Esteve

Gastroenterology Department, Hospital Universitari Mútua Terrassa, Universitat de Barcelona, Terrassa. Centro de Investigación Biomédica en red de enfermedades hepáticas y digestivas CIBERehd, Gastroenterology Department, Terrassa, Spain

P040 Proteomic characterisation of serum extracellular vesicles in patients with inflammatory bowel diseases: a novel approach for biomarker discovery

ECCO'20 Vienna

Year: 2020
Authors:

M. Chaparro1, M. Azkargorta2, A. Lapitz3, L. Ortega-Moreno1, I. Iloro2, A. Arbelaiz3, I. Escobes2, S. Fernández-Tomé1, A.C. Marin1, M. Baldan-Martin1, J.M. Falcon-Perez2, L. Bujanda3, D. Bernardo1, J. Banales3, F. Elortza2, J.P. Gisbert1

1Hospital Universitario de La Princesa, Instituto de Investigación Sanitaria Princesa IIS-IP, Universidad Autónoma de Madrid, and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas CIBERehd, Gastroenterology, Madrid, Spain, 2CIC bioGUNE, CIBERehd, ProteoRed-ISCIII, Proteomics Platform, Derio, Spain, 3Biodonostia Research Institute. Donostia University Hospital and CIBERehd, Liver Diseases Group, San Sebastian, Spain

P041 Melatonin controls microbiota in colitis through Toll-like receptor 4 signalling

ECCO'20 Vienna

Year: 2020
Authors:

Y.S. Park1, S.W. KIm2, J.H. Cheon2

1Department of Gastroenterology, Eulji University College of Medicine, Seoul, Korea- Republic of, 2Department of Internal Medicine and Institute of Gastroenterology, Yonsei University College of Medicine, Seoul, Korea- Republic of Korea

P042 Patient perspective on the impact of complex perianal fistulas in Crohn’s disease on quality of life: introducing the concept of the patient survey conducted in Europe

ECCO'20 Vienna

Year: 2020
Authors:

A. Spinelli1, S. Lönnfors2, L. Avedano2, D. Bojic3

1Department of Biomedical Sciences, Humanitas University, Rozzano Milano, Italy, 2European Federation of Crohn’s and Ulcerative Colitis Associations, n/a, Brussels, Belgium, 3Takeda Pharmaceuticals International AG, Medical Affairs Europe and Canada, Zurich, Switzerland

P043 Small intestinal inflammation but not colitis drives pro-inflammatory nutritional antigen-specific T-cell response

ECCO'20 Vienna

Year: 2020
Authors:

Y. Rodríguez Sillke1,2, M. Schumann1, D. Lissner1, F. Branchi1, R. Glauben1, B. Siegmund1

1Medical Department of Gastroenterology, Charité Universitätsmedizin Berlin, Berlin, Germany, 2Institute of Nutrition, University of Potsdam, Nuthetal, Germany

P044 Milk derived exosomes has a therapeutic effect on experimental colitis

ECCO'20 Vienna

Year: 2020
Authors:

R. Golan-Gerstl1, N. Koroukhov1, Y. Elbaum Shiff2, I. Shilo1, S. Reif2

1Department of Pediatrics, Hadassah-Hebrew University Medical Center, Jerusalem, Israel, 2School of Nutritional Sciences, Hebrew University of Jerusalem, Jerusalem, Israel

P045 Profiling of human circulating dendritic cells and monocytes subsets discriminates type and mucosal status in patients with inflammatory bowel disease

ECCO'20 Vienna

Year: 2020
Authors:

L. Ortega Moreno1, S. Fernández Tomé1, M. Chaparro1, A. Marin1, I. Mora Gutiérrez1, C. Santander1, M. Baldán1, J. Gisbert1, D. Bernardo2

1Hospital Universitario de La Princesa, Medicina, Madrid, Spain, 2Universidad de Valladolid, Instituto de Biología y Genética Molecular, Valladolid, Spain

P046 Vitamin D decreases PDIA3 and prevents the enhanced migration of fibroblasts from stricturing Crohn’s disease

ECCO'20 Vienna

Year: 2020
Authors:

L. Gisbert-Ferrandiz1, J. Cosín-Roger2, S. Coll1, C. Bauset1, D. Ortiz-Masiá3, F. Navarro-Vicente4, R. Alos5, S. Calatayud1, M.D. Barrachina1

1Department of Pharmacology, University Of Valencia, Valencia, Spain, 2FISABIO, Hospital Dr.Peset, Valencia, Spain, 3Department of Medicine, University Of Valencia, Valencia, Spain, 4Hospital Manises, Surgery, Valencia, Spain, 5Hospital La Fe, Surgery, Valencia, Spain

P047 Differences in extra cellular matrix remodelling in highly active Crohn’s disease and ulcerative colitis

ECCO'20 Vienna

Year: 2020
Authors:

V. Domislović1, J.H. Mortensen2, M.A. Karsdal2, M. Brinar1, T. Manon-Jensen2, Ž. Krznarić1

1Department of Gastroenterology and Hepatology, Clinical Hospital Centre Zagreb, Zagreb, Croatia, 2Nordic Bioscience A/S, Biomarkers and Research, Herlev, Denmark

P048 Mucosal macrophages express elevated levels of HDAC9 in inflamed and uninflamed mucosa of Crohn’s disease, but not ulcerative colitis

ECCO'20 Vienna

Year: 2020
Authors:

M. Ghiboub1, J. de Bruyn1, K. Reedquist2, T. Radstake3, C. Wichers2, M. Wildenberg1, J. Broen3, G. D’Haens4, W. de Jonge1

1Tytgat Institute for Liver and Intestinal Research, Amsterdam University Medical Center, Amsterdam, The Netherlands, 2Laboratory of Translational Immunology, University Medical Center Utrecht, Utrecht, The Netherlands, 3Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands, 4Pediatric Gastroenterology and Nutrition, Amsterdam University Medical Center, Amsterdam, The Netherlands

P049 A new preclinical rationale for first-line therapy of ulcerative colitis

ECCO'20 Vienna

Year: 2020
Authors:

H. Thorlacius1, A. Bjoerk2, Ö. Nordle2, G. Hedlund2

1Department of Clinical Sciences, Section of Surgery Skåne University Hospital Lund University, Malmö, Sweden, 2Pharmacyl AB, Preclinical Research, Bjärred, Sweden

P050 Analysis of 61 exclusive enteral nutrition formulas used for induction of remission in Crohn’s disease: new insights on dietary disease triggers

ECCO'20 Vienna

Year: 2020
Authors:

M. Logan1, K. Gkikas1, V. Svolos1, B. Nichols1, S. Milling2, U. Ijaz3, R. Hansen4, R.K. Russell4, K. Gerasimidis1, BINGO (Bacteria Inflammation Nutrition Gastroenterology and Omics)

1University of Glasgow, Human Nutrition, Glasgow, UK, 2University of Glasgow, Infection- Immunity and Inflammation, Glasgow, UK, 3University of Glasgow, School of Engineering, Glasgow, UK, 4Greater Glasgow and Clyde NHS, Paediatric gastroenterology, Glasgow, UK

P051 Quantifying inflammation and fibrosis through a surgical histopathological score can differentiate ileal Crohn’s disease phenotypes and predict postoperative progressive disease

ECCO'20 Vienna

Year: 2020
Authors:

H. Tavares de Sousa1,2, I. Gullo3,4,5, C. Castelli6, C.C. Dias7,8, F. Magro9,10,11

1Algarve University Hospital Centre, Gastroenterology Department – Portimão Unit, Portimão, Portugal, 2ABC – Algarve Biomedical Centre, University of Algarve, Faro, Portugal, 3São João University Hospital and Faculty of Medicine, Department of Pathology, Porto, Portugal, 4University of Porto, Institute of Investigation and Inovation in Health i3S, Porto, Portugal, 5Institute of Molecular Pathology and Immunology of the University of Porto Ipatimup, Institute of Molecular Pathology and Immunology of the University of Porto Ipatimup, Porto, Portugal, 6University and Hospital Trust of Verona, Department of Diagnostics and Public Health- section of Pathology, Verona, Italy, 7Faculty of Medicine, University of Porto, Portugal, Department of Community Medicine, Information and Decision in Health, Porto, Portugal, 8University of Porto, Centre for Health Technology and Services Research, Porto, Portugal, 9Faculty of Medicine, University of Porto, Department of Biomedicine, Unit of Pharmacology and Therapeutics, Porto, Portugal, 10MedInUP, Centre for Drug Discovery and Innovative Medicines, MedInUP, Centre for Drug Discovery and Innovative Medicines, Porto, Portugal, 11São João University Hospital, Department of Gastroenterology, Porto, Portugal

P052 Nuclear magnetic resonance metabolomic profiling of IBD patients under anti-TNF treatment. Are the pathways network deregulated?

ECCO'20 Vienna

Year: 2020
Authors:

S. Notararigo1, M. Martin-Pastor2, J.E. Dominguez Munoz3, M. Barreiro-de Acosta3

1University Hospital Santiago De Compostela CHUS, Fundación IDIS, Santiago De Compostela, Spain, 2University Santiago de Compostela, Unidad de Resonancia Magnética, Cactus, Riaidt, Spain, 3University Hospital Santiago De Compostela CHUS, Department of Gastroenterology, IBD Unit, Santiago De Compostela, Spain

P053 3-Oxo-C12:2, a quorum sensing molecule from the human gut, exerts anti-inflammatory effects through a bitter taste receptor

ECCO'20 Vienna

Year: 2020
Authors:

G. Coquant, D. Aguanno, A. Peyrottes, L. Brot, S. Thenet, J.P. Grill, L. De Sordi, P. Seksik

INSERM, Pierre and Marie Curie University, CRSA UMRS_938 Team Microbiota Intestine and Inflammation, Paris, France

P054 The impact of intestinal stenosis on the expression of Crohn’s disease in young mice with genetic predisposition

ECCO'20 Vienna

Year: 2020
Authors:

I. Georgopoulos1, E. Mavrigiannaki1, S. Stasinopoulou2, G. Renieris3, G. NIkolakis4, G. Kollias5, D. Tiniakos6, I. Papaconstantinou7

1’Agia Sofia’ Children’s Hospital of Athens, Department of Surgery, Athens, Greece, 2417 Veterans Administration Hospital NIMTS, Department of Pathology, Athens, Greece, 3National and Kapodistrian University of Athens, Medical School, 4th Department of Internal Medicine, Athens, Greece, 4Dessau Medical Center, Medical School Brandenburg Theodor Fontane, Departments of Dermatology, Venereology, Allergology and Immunology, Dessau, Germany, 5National and Kapodistrian University of Athens, Medical School, Department of Physiology, Athens, Greece, 6Aretaieion Hospital, Medical School, National and Kapodistrian University of Athens, Department of Pathology, Athens, Greece, 7National and Kapodistrian University of Athens, Medical School, Aretaieion University Hospital, Second Department of Surgery, Athens, Greece

P055 Effect of Mimosa caesalpiniifolia extract on DSS-induced colitis in Wistar rats

ECCO'20 Vienna

Year: 2020
Authors:

A. Garnevi Fávero1, T.S. Cordeiro1, K.N. Silva1, L. Cardili2, M.J.D. Silva3, A.P.R. Paiotti1

1Universidade Federal de São Paulo – Escola Paulista de Medicina UNIFESP/EPM, Discipline of Gastroenterology, Sao Paulo, Brazil, 2Universidade Federal de São Paulo – Escola Paulista de Medicina UNIFESP/EPM, Pathology, Sao Paulo, Brazil, 3Universidade Estadual Paulista, UNESP, São Vicente, Brazil, Biosciences Institute, Sao Paulo, Brazil

P056 Kefir (Lactobacillus kefiranofaciens) promotes autophagy and protects the intestinal barrier against DSS-induced colitis

ECCO'20 Vienna

Year: 2020
Authors:

K.N. Da Silva1, T.S. Cordeiro1, A.G. Fávero1, C.S. Bogsan2, R.D.C. Sinigaglia3, S.J. Miszputen1, O. Ambrogini–Júnior1, A.P.R. Paiotti1

1Universidade Federal de São Paulo – Escola Paulista de Medicina UNIFESP/EPM, Discipline of Gastroenterology, Sao Paulo, Brazil, 2Universidade de São Paulo – USP, Faculty of Pharmaceutical Sciences, São Paulo, Brazil, 3Universidade Federal de São Paulo – Escola Paulista de Medicina UNIFESP/EPM, Electron Microscopy Center, Sao Paulo, Brazil

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