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P051: DNA methylation signatures associated with pathogenesis Crohn's disease-related genes

ECCO '19 Copenhagen

Year: 2019
Authors:

I. Moret Tatay1,2, E. Cerrillo1,3, E. Sáez-González1,3, D. Hervás4, M. Iborra1,2,3, J. Sandoval5, E. Busó6, L. Tortosa1,2, P. Nos1,2,3, B. Beltrán1,2,3

1IIS Hospital La Fe, Gastroenterology, Valencia, Spain, 2Networked Biomedical Research Centre for Hepatic and Digestive Diseases (CIBEREHD), Madrid, Spain, 3Hospital Universitari i Politècnic La Fe, Inflammatory Bowel Disease Unit, Gastroenterology Department, Valencia, Spain, 4IIS Hospital La Fe, Biostatistics, Valencia, Spain, 5IIS Hospital La Fe, Biomarkers and Precision Medicine, Valencia, Spain, 6University of Valencia, Central Unit for Research in Medicine (UCIM), Valencia, Spain

P052: Heat shock protein GP96 is essential for maintaining intestinal epithelial architecture by supporting its self-renewal capacity

ECCO '19 Copenhagen

Year: 2019
Authors:

J. Häfliger1, M. Schwarzfischer1, M. Van de Sande1, R. Manzini1, C. Stanzel1, K. Atrott1, S. Lang1, M. Scharl1, M. Spalinger1

1University Hospital Zurich, University of Zurich, Department of Gastroenterology and Hepatology, Zurich, Switzerland

P053: Adipose-derived stem cells ameliorate colitis by suppression of inflammasome formation and regulation of M1-macrophage population through prostaglandin E2

ECCO '19 Copenhagen

Year: 2019
Authors:

H-S. Kim*1, H. Park1, Y. Eom1

1Wonju College of Medicine, Yonsei University, Wonju, South Korea

P054: CD103+SIRPα+ DC are specifically decreased in the inflamed colon from patients with ulcerative colitis but not with Crohn’s disease

ECCO '19 Copenhagen

Year: 2019
Authors:

D. Bernardo*1, S. Fernandez-Tome1, A. C. Marin1, L. Ortega-Moreno1, A. Montalban-Arques1, I. Mora-Gutierrez1, A. Fiz-Lopez1, F. Casals1, J. A. Moreno-Monteagudo1, T. Alvarez-Male1, V. Martin1, I. Becerro1, M. J. Casanova1, C. Santander1, M. Chaparro1, J. P. Gisbert1

1Insittuto Investigación Princesa, Madrid, Spain

P055: Transcriptional profiling of ulcerative colitis in remission

ECCO '19 Copenhagen

Year: 2019
Authors:

C. Fenton1, H. Taman2, J. Florholmen3, R. H. Paulssen*4

1UiT-The Arctic University of Norway, Clinical Medcine, Tromsø, Norway, 2UiT-The Arctic University of Norway, Clinical Medicine, Tromsø, Norway, 3University Hospital of North Norway, Gastroenterology and Nutrition, Tromsø, Norway, 4UiT – The Arctic University of Norway, Clinical Medicine, Tromsø, Norway

P056: Transcriptional profiling of intestinal epithelial organoids derived from paediatric Crohn’s disease patients

ECCO '19 Copenhagen

Year: 2019
Authors:

I. Dotti*1, E. Ferrer-Picón1, N. Planell1, J. Martín de Carpi2, G. Pujol2, M. Masamunt1, M. Esteller1, A. Carrasco3, L. Alvarez2, E. Tristán3, I. Ordás1, M. Esteve3, E. Ricart1, A. Salas1

1IDIBAPS, Hospital Clínic, CIBERehd, Department of Gastroenterology, Barcelona, Spain, 2Hospital Sant Joan de Deu, Department of Gastroenterology, Hepatology and Pediatric Nutrition, Barcelona, Spain, 3Hospital Universitari Mutua Terrassa, Department of Gastroenterology, Terrassa, Barcelona, Spain

P057: Gut microbiome diversity in acute severe colitis is distinct from mild-to-moderate ulcerative colitis

ECCO '19 Copenhagen

Year: 2019
Authors:

S. Kedia*1, T. S. Ghosh2, B. Das2, S. Jain1, S. Bopanna1, G. Makharia1, S. Travis3, V. Ahuja1

1All India Institute of Medical Sciences, New Delhi, India, 2Translational Health Science and Technology Institute, Faridabad, India, 3John Radcliffe Hospital, Translational Gastroenterology Unit, Oxford, UK

P058: Do circulating exosomes interfere with vedolizumab efficacy in IBD patients?

ECCO '19 Copenhagen

Year: 2019
Authors:

R. Domenis1, A. Cifu'1, M. Fabris1,2, G. Scardino3, M. Zilli3, M. Marino*3, F. Curcio1,2

1University Hospital of Udine, Dipartimento di Area Medica, Udine, Italy, 2University Hospital of Udine, Istituto di Patologia Clinica, Udine, Italy, 3University Hospital of Udine, Gastroenterology, Udine, Italy

P059: The metformin inhibits MDSC and M2 macrophage via AMPK-induced inhibition of HMG-CoA reductase in tumour microenvironment of colitic cancer

ECCO '19 Copenhagen

Year: 2019
Authors:

J. Y. Kang1, Y. H. Park1, S. J. Park1, J. H. Cheon1, W. H. Kim1, T. I. Kim*1

1Yonsei University College of Medicine, Internal Medicine, Seoul, South Korea

P060: The protective effect of necrosis inhibition on acute murine colitis induced by dextran sulphate sodium

ECCO '19 Copenhagen

Year: 2019
Authors:

D. Kim*1, J. S. Koo1, J. H. Park1, S. H. Hwang1, D. Lee1, J. W. Choe1, J. J. Hyun1, S. W. Jung1, Y. T. Jeen2, S. W. Lee1

1Korea University Ansan Hospital, Internal medicine, Ansan, South Korea, 2Korea University Anam Hospital, Internal medicine, Seoul, South Korea

P061: Succinate promotes EMT in intestinal epithelial cells through SUCNR1: Relevance in fistula development

ECCO '19 Copenhagen

Year: 2019
Authors:

J. Cosin-Roger*1,2, D. Ortiz-Masia3, M. Aragón-Borrego1, L. Gisbert-Ferrándiz1, S. Calatayud1, M. D. Barrachina1

1University of Valencia, Pharmacology, Valencia, Spain, 2Hospital Dr Peset, Valencia, Spain, 3University of Valencia, Medicine, Valencia, Spain

P062: Differences in immune cell population subsets in inflammatory bowel disease patients under anti-TNF treatment

ECCO '19 Copenhagen

Year: 2019
Authors:

S. Notararigo*1,2, J. E. Viñuela Roldán3, M. Abanades-Tercero4, J. E. Dominguez-Munoz1, M. Barreiro-de Acosta1

1University Hospital, Gastroenterology, Santiago de Compostela, Spain, 2Fundación Ramón Domínguez, Santiago, Spain, 3University Hospital, Immunology, Santiago, Spain, 4Hospital Virgen de la Salud, Gastroenterology, Toledo, Spain

P063: Representative and comprehensive analysis of colonic and ileac biopsies from IBD patients by gene expression profiling using the straightforward, fast, and affordable novel application Whole Transcriptome AmpliSeq on the Ion Torrent NGS platform

ECCO '19 Copenhagen

Year: 2019
Authors:

F. Raulf*1, L. Roth1, C. Delucis-Bronn1, A. Begrich1, G. Wieczorek1, D. Picard2, J. Rush1, C. Beglinger3, P. Hruz4

1Novartis Pharma AG / NIBR, Autoimmunity, Transplantation and Inflammation Disease Area, Basel, Switzerland, 2Novartis Pharma AG / NIBR, Translational Medicine, Basel, Switzerland, 3University Basel, Deaprtment of Biomedicine, Basel, Switzerland, 4University Hospital Basel, Gastroenterology and Hepatology, Basel, Switzerland

P064: The role of the vagal innervation in a DSS-induced colitis mouse model

ECCO '19 Copenhagen

Year: 2019
Authors:

G. Lo Sasso*1, B. Phillips2, C. Foong2, M. Talikka1, A. Sewer1, A. Kondylis1, N. V. Ivanov3, J. Hoeng1

1Philip Morris International, PMI Science and Innovation, System Toxicology, Neuchatel, Switzerland, 2Philip Morris International Laboratories, PMI Science and Innovation, Pre-clinical Toxicology, Singapore, Singapore, 3Philip Morris International, PMI Science and Innovation, Biomarker and Biosensor Research, Neuchatel, Switzerland

P065: Olfactory receptor, OR51E2 is a marker for innate immune cells in ulcerative colitis

ECCO '19 Copenhagen

Year: 2019
Authors:

B. J. Lee*1, N. J. Kim1, S. B. Park1, J. S. Koo1, Y. T. Jeen1, J. J. Park1, M. K. Joo1

1Korea University, Seoul, South Korea

P066: Validation of assay for detection of free soluble mucosal addressin cell adhesion molecule-1 (MAdCAM-1) in human serum and cerebrospinal fluid

ECCO '19 Copenhagen

Year: 2019
Authors:

M. Fernandez Ocana1, J. Y. Zhang2, B. R. Jones3, S. W. Martin2, M. Goetsch*4, H. Neubert1

1Pfizer, Andover, MA, USA, 2Pfizer, Cambridge, MA, USA, 3Q2 Solutions, Ithaca, NY, USA, 4Shire, Zug, Switzerland

P067: Human colonic subepithelial myofibroblasts from IBD patients demonstrate a differential expression of Th-related cytokine receptors compared with healthy controls

ECCO '19 Copenhagen

Year: 2019
Authors:

G. Bamias4, E. Filidou1, V. Valatas2, I. Drygiannakis2, K. Arvanitidis1, S. Vradelis3, G. Kouklakis*3, G. Kolios1

1Democritus University of Thrace, Laboratory of Pharmacology, Faculty of Medicine, Alexandroupolis, Greece, 2University of Crete, Laboratory of Gastroenterology, Faculty of Medicine, Heraklion, Greece, 3Democritus University of Thrace, University Hospital of Alexandroupolis, Alexandroupolis, Greece, 4GI Unit, 3rd Academic Department of Internal Medicine, National and Kapodistrian University of Athens Sotiria Hospital, Athens, Greece

P068: Aberrant brain function in active-stage ulcerative colitis patients: a resting-state functional MRI study

ECCO '19 Copenhagen

Year: 2019
Authors:

W. Fan*1, S. Zhang1, J. Hu1, B. Liu1, L. Wen1, M. Gong1, G. Wang1, L. Yang2, Y. Chen2, H. Chen2, H. Guo2, D. Zhang1

1新桥医院, Radiology Department, Chongqing, China, 2新桥医院, Gastroenterology Department, Chongqing, China

P069: New methylation biomarker panel of inflammatory Mucosa in Korean Crohn’s disease

ECCO '19 Copenhagen

Year: 2019
Authors:

S. M. Lee1, T. O. Kim*2

1Dongnam Institute of Radiological and Medical Sciences (DIRAMS), Busan, South Korea, 2Inje University Haeundae Paik Hospital, Busan, South Korea

P070: The level of nuclear factor kappa B (NF-kB) translocation during infliximab therapy in children with IBD

ECCO '19 Copenhagen

Year: 2019
Authors:

S. Petrichuk1, T. Radigina1, D. Gerasimova1, A. Illarionov2,3, A. Anushenko2, T. Erlikh-Fox4, A. Potapov*2

1National Medical Research Center for Children's Health, Laboratory of Experimental Immunology and Virology, Moscow, Russian Federation, 2National Medical Research Center for Children's Health, Gastroenterology and Hepatology, Moscow, Russian Federation, 3Sechenov First Moscow State Medical University, Department of Pediatrics and Pediatric Rheumatology, Moscow, Russian Federation, 4National Medical Research Center for Children's Health, Cytochemical Research Center, Moscow, Russian Federation

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