P026: Differential effects of tofacitinib on macrophage activation may contribute to lack of response in ulcerative colitis patientsECCO'24Year: 2024
Authors: Melón-Ardanaz, E.(1,2)*;Veny, M.(1,2);Corraliza, A.M.(1,2);Garrido-Trigo, A.(1,2);Gudiño, V.(1,2);Moro, M.(1,2);Sanzo-Machuca, Á.(1,2);Esteller, M.(1,2);Masamunt, M.C.(1,2);Caballol, B.(1,2);Ordás, I.(1,2);Fernández-Clotet, A.(1,2);Ricart, E.(1,2);Panés, J.(1,2);Salas, A.(1,2);
(1)Institut d@E@Investigacions Biomèdiques August Pi i Sunyer IDIBAPS, Hospital Clinic of Barcelona - Inflammatory Bowel Disease Unit, Barcelona, Spain;(2)Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas, CiberEHD, Madrid, Spain;
P027: Involvement of PD-L1 in myenteric plexitis associated with postoperative recurrence of Crohn@E@s diseaseECCO'24Year: 2024
Authors: Le Berre, C.(1)*;Durand, T.(2);Clavreul, M.(2);Neunlist, M.(2);Bourreille, A.(1);Neveu, I.(2);Naveilhan, P.(2);
(1)CHU Hôtel Dieu, Gastroenterology, Nantes, France;(2)Nantes Université, Inserm UMR1235 TENS, Nantes, France;
P028: A pathogenic role of activated mucosal-associated invariant T cells in an animal model of Inflammatory Bowel DiseaseECCO'24Year: 2024
Authors: Yasutomi, Y.(1);Chiba, A.(1);Haga, K.(2);Murayama, G.(3);Makiyama, A.(3);Kuga, T.(3);Nagahara, A.(2);Nagaishi, T.(4)*;Miyake, S.(1);
(1)Juntendo University, Immunology, Tokyo, Japan;(2)Juntendo University, Gastroenterology, Tokyo, Japan;(3)Juntendo University, Rheumatology, Tokyo, Japan;(4)Tokyo Medical and Dental University, Gastroenterology, Tokyo, Japan;
P029: Loss of adipose tissue protects mice from intestinal inflammationECCO'24Year: 2024
Authors: Omar, T.(1)*;Letizia, M.(1);Siegmund, B.(1);Weidinger, C.(1);
(1)Charité – Universitätsmedizin Berlin- corporate member of Freie Universität Berlin and Humboldt -Universität zu Berlin, Department of Gastroenterology- Infectious Diseases and Rheumatology, Berlin, Germany;
P031: Microbiota-driven appendiceal B lymphocytes aggravate DSS-induced murine colitis through facilitating colonic CD4+ T cells polarizationECCO'24Year: 2024
Authors: Zhang, Y.(1)*;Xu, J.(1);Liu, Y.(1);Ke, Z.(1);Fang, X.(1);Zhang, Y.(1);Liu, Y.(1);
(1)Peking University People@E@s Hospital, Department of Gastroenterology- Clinical Center of Immune-Mediated Digestive Diseases, Beijing, China;Topic 1: Basic Science
P032: Exploring the genetic sequence of action across the natural history of IBD.ECCO'24Year: 2024
Authors: Mateos, B.(1)*;Gaite-Reguero, A.(1);Rodríguez-Lago, I.(2);M. Marigorta, U.(1);
(1)CIC bioGUNE, Integrative Genomics, Derio, Spain;(2)Hospital Universitario de Galdakao, Gastroenterology, Galdakao, Spain;
P033: Unrevealing new potential key mechanisms implicated in inflammatory bowel disease by multiomic approach.ECCO'24Year: 2024
Authors: Baldan-Martin, M.(1)*;Azkargorta, M.(2);Aransay, A.M.(3);Gil-Redondo, R.(4);Moreno-Indias, I.(5);Iloro, I.(2);Soleto, I.(1);Orejudo, M.(1);Ramírez , C.(1);Lucendo, A.J.(6);Rodríguez Gutiérrez, C.(7);Gutiérrez, A.(8);Martín Arranz, E.(9);Bujanda, L.(10);Rodríguez-Lago, I.(11);Riestra, S.(12);Iglesias-Flores, E.(13);Bermejo, F.(14);Van Domselaar, M.(15);García, M.J.(16);Fernández Salazar, L.(17);Barrio Andrés, J.(18);Calvet, X.(19);Torrealba, L.(20);Bastón Rey, I.(21);Pallarés, H.(22);Ber, Y.(23);Carnerero, E.L.(24);Casanova, M.J.(1);Casals, F.(1);Mendoza, J.(1);Moreno Monteagudo, J.A.(1);Millet, Ó.(4);Elortza, F.(2);Mato, J.M.(4);Tinahones, F.J.(5);Chaparro*, M.(1);Gisbert*, J.P.(1);
(1)Hospital Universitario de La Princesa- Instituto de Investigación Sanitaria Princesa IIS-Princesa and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas CIBERehd- Madrid. Spain, Gastroenterology Unit, Madrid Madrid, Spain;(2)CIC bioGUNE- BRTA Basque Research & Technology Alliance- CIBERehd, Proteomics Platform, Derio, Spain;(3)CIC bioGUNE- Basque Research and Technology Alliance BRTA- CIBERehd, Genome Analysis Platform, Derio, Spain;(4)CIC bioGUNE, Precision Medicine and Metabolism Lab, Derio, Spain;(5)Virgen de la Victoria University Hospital- Málaga- Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y la Nutrición CIBEROBN- Instituto de Salud Carlos III, Department of Endocrinology and Nutrition, Madrid, Spain;(6)Hospital General de Tomelloso- Instituto de Investigación Sanitaria de Castilla-La Mancha IDISCAM- CIBERehd, Gastroenterology Unit, Ciudad Real, Spain;(7)Hospital Universitario de Navarra, Gastroenterology Unit, Pamplona, Spain;(8)Hospital General Universitario de Alicante- CIBERehd and Instituto Investigación Sanitaria y Biomédica de Alicante, Gastroenterology Unit, Alicante, Spain;(9)Hospital Universitario La Paz and Instituto de Investigación Sanitaria La Paz IdiPaz- UAM, Gastroenterology Unit, Madrid, Spain;(10)Hospital Universitario Donostia and Instituto Biodonostia. Universidad del País Vasco UPV/EHU, Gastroenterology Unit, Donostia, Spain;(11)Hospital Universitario de Galdakao- Biocruces Bizkaia HRI, Gastroenterology Unit, Vizcaya, Spain;(12)Hospital Universitario Central de Asturias and Instituto de Investigación Sanitaria del Principado de Asturias ISPA, Gastroenterology Unit, Oviedo, Spain;(13)Hospital Universitario Reina Sofia, Gastroenterology Unit, Córdoba, Spain;(14)Hospital Universitario de Fuenlabrada, Gastroenterology Unit, Madrid, Spain;(15)Hospital Universitario de Torrejón, Gastroenterology Unit, Madrid, Spain;(16)Hospital Universitario Marqués de Valdecilla- IDIVAL- Universidad de Cantabria, Gastroenterology and Hepatology Department, Santander, Spain;(17)Hospital Clínico Universitario de Valladolid, Gastroenterology Unit, Valladolid, Spain;(18)Hospital Universitario Rio Hortega, Gastroenterology Unit, Valladolid, Spain;(19)Consorci Corporació Santitària Parc Taulí- CIBERehd. Sabadell, Gastroenterology Unit, Sabadel, Spain;(20)Hospital Universitario Dr. Josep Trueta, Gastroenterology Unit, Girona, Spain;(21)Hospital Clínico Universitario de Santiago, Gastroenterology Unit, Santiago de Compostela, Spain;(22)Hospital Juan Ramón Jiménez, Gastroenterology Unit, Huelva, Spain;(23)Hospital San Jorge, Gastroenterology Unit, Huesca, Spain;(24)Hospital Universitario Virgen del Rocío, Gastroenterology Unit, Sevilla, Spain;*Authors share co-senior authorship.
P034: Peripheral immune cell activity and biopsy gene expression in chronic pouchitis patients treated with tofacitinib: early induction results from the STOPit trial.ECCO'24Year: 2024
Authors: Davies, J.(1)*;Amiss, A.(1);Khoo, E.(1,2);An, Y.K.(1,2);Begun, J.(1,2);
(1)Mater Research - The University of Queensland, Chronic and Integrated Care, Woolloongabba, Australia;(2)Mater Adult Hospital- Mater Misericordiae Limited, Department of Gastroenterology, South Brisbane, Australia;
P035: 3D bioprinting of gelatin derivatives: towards novel small intestinal in vitro modelsECCO'24Year: 2024
Authors: Maes, L.(1)*;Szabó, A.(2);Van Haevermaete, J.(2);Geurs, I.(2);Dewettinck, K.(3);Van Vlierberghe, S.(2);Laukens, D.(1);
(1)Ghent University, Internal Medicine and Pediatrics, Ghent, Belgium;(2)Ghent University, Organic and Macromolecular Chemistry, Ghent, Belgium;(3)Ghent University, Food Technology- Safety and Health, Ghent, Belgium;IBD Research Unit
P036: Microbiota Metabolite Butyrate Attenuates Intestinal Inflammation Through Autophagy ActivationECCO'24Year: 2024
Authors: Mao, Q.(1,2)*;Zhang, W.(1,2);Zhang, Y.(1,2);Lin, B.(1,2);Cao, Q.(1,2);Xu, M.(1,2);
(1)Sir Run Run Shaw Hospital- College of Medicine Zhejiang University, Department of Gastroenterology, Hangzhou, China;(2)Sir Run Run Shaw Hospital- College of Medicine Zhejiang University, Inflammatory bowel disease center, Hangzhou, China;
P037: Modelling gut complexity and disease: development of a next-generation adult stem cell based tubular gut-on-a-chip modelECCO'24Year: 2024
Authors: Kosim, K.(1)*;Bokkers, M.(1);Oudshoorn, J.(1);van Heusden, T.(1);Morelli, M.(1);Kurek, D.(1);van den Broek, L.(1);Joore, J.(1);Vulto, P.(1);
(1)Mimetas, Model Development, Oegstgeest, The Netherlands;
P040: Prediction of endoscopic features of disease from single-cell RNA sequencing data in sigmoid colon of patients with ulcerative colitisECCO'24Year: 2024
Authors: Riva, A.(1);Primas, C.(2);Wiekowski, M.(3);Badalamenti, S.(3);Reinisch, W.(2);Busslinger, G.(1,2)*;
(1)Research Center for Molecular Medicine CeMM, Research Center for Molecular Medicine CeMM, Vienna, Austria;(2)Medical University of Vienna, Division of Gastroenterology and Hepatology, Vienna, Austria;(3)Sanofi Pharmaceuticals, Development- Immunity & Inflammation, New Jersey, United States;
P041: Assessment of Serum Biomarkers associated with Vedolizumab Therapy Response in Inflammatory Bowel Disease.ECCO'24Year: 2024
Authors: O@E@Connell, J.(1)*;Argue, R.(1);Dunne, M.(2);O@E@Connell, F.(2);Breslin, N.(3);Cullen, G.(4);Doherty, G.(4);Dunne, C.(1);Hartery, K.(1);Ismail, M.S.(3);MacCarthy, F.(1);McDonagh, P.(1);McKiernan, S.(1);McNamara, D.(3);Mulcahy, H.(4);O@E@Connor, A.(3);Ryan, B.(3);Sheridan, J.(4);O@E@Sullivan , J.(2);Kevans, D.(1);
(1)St James@E@s Hospital, Gastroenterology, Dublin, Ireland;(2)Trinity Translational Medicine Institute- Trinity College Dublin, Surgery, Dublin, Ireland;(3)Tallaght University Hospital, Gastroenterology, Dublin, Ireland;(4)St Vincent@E@s University Hospital, Gastroenterology, Dublin, Ireland;
P042: Significant correlation between intestinal ultrasound and magnetic resonance enterography for assessing disease activity and complications in Crohn’s diseaseECCO'24Year: 2024
Authors: Bárbara, A.(1)*;Manso, M.(2);Bravo, C.(1);Reves, J.(1);Nascimento, C.(1);Gomes, C.(1);Torres, J.(1);Palmela, C.(1);
(1)Hospital Beatriz Ângelo, Gastroenterology, Lisbon, Portugal;(2)Hospital Beatriz Ângelo, Radiology, Lisbon, Portugal;
P043: RIPK3 – a new marker for assessment of activity in Crohn’s diseaseECCO'24Year: 2024
Authors: PanayotovaMD, E.(1)*;Atanassova, A.(2);
(1)Medical University- Varna / University Hospital St.Marina - Varna- Bulgaria, Department of Propedeutics of Internal Diseas / Clinic of Internal medicine, Varna, Bulgaria;(2)Medical University- Varna / University Hospital St.Marina - Varna- Bulgaria, Clinic of Gastroenterology, Varna, Bulgaria;
P044: Evaluation of the CO2 Footprint of Laparoscopic Ileocecal Resection for Terminal Ileitis in Crohn@E@s DiseaseECCO'24Year: 2024
Authors: Munster, L.(1)*;van der Zwet, B.M.(1);de Groof, E.J.(1);Mundt, M.W.(2);D@E@Haens, G.R.A.M.(3);Bemelman, W.A.(4);Buskens, C.J.(4);Stobernack, T.(5);van der Bilt, J.D.W.(1);
(1)Flevoziekenhuis/Amsterdam UMC- location AMC, Surgery, Amsterdam, The Netherlands;(2)Flevoziekenhuis, Gastroenterology and Hepatology, Almere, The Netherlands;(3)Amsterdam UMC- location AMC, Gastroenterology and Hepatology, Amsterdam, The Netherlands;(4)Amsterdam UMC- location AMC, Surgery, Amsterdam, The Netherlands;(5)Radboudumc, Sustainability, Nijmegen, The Netherlands;
P045: MMP12 stimulates colonic afferents, and nociceptors through the activation of PAR1ECCO'24Year: 2024
Authors: Gupta, R.(1);Higham, J.(1);Raine, T.(2);Wright, P.(3);Bulmer, D.(1)*;
(1)University of Cambridge, Pharmacology, Cambridge, United Kingdom;(2)Addenbrookes Hospital, Gastroenterology, Cambridge, United Kingdom;(3)LifeArc, Therapeutics Discovery, Stevenage, United Kingdom;
P046: Real-world data on the treatment with Mirikizumab in a mostly biological-experienced Ulcerative colitis cohortECCO'24Year: 2024
Authors: Lande, R.(1)*;Kubesch, A.(1);Farrag, K.(1);Dienethal, A.(1);Sprinzl, K.(1);Zeuzem, S.(1);Blumenstein, I.(1);
(1)Goethe University Frankfurt- University Hospital- Medical Clinic 1, Department of Gastroenterology and Hepatology, Frankfurt, Germany;
