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P014: Mucosal lymphocyte subsets in ulcerative colitis at diagnosis and during follow-upECCO '17 Barcelona
Year: 2017
Authors:

Smids C.*1, Horjus Talabur Horje C.1, Groenen M.1, van Koolwijk E.2, Wahab P.1, van Lochem E.2

1Rijnstate Hospital, IBD Centre, Gastroenterology and Hepatology, Arnhem, Netherlands 2Rijnstate Hospital, Microbiology and Immunology, Arnhem, Netherlands

P015: Wnt10b promotes fibrosis in murine colitisECCO '17 Barcelona
Year: 2017
Authors:

Ortiz-Masia D.*1,2, Salvador P.3, Macias-Ceja D.C.4, Gisbert-Ferrándiz L.3, Hernandez C.4, Calatayud S.3, Esplugues J.V.3,4, Barrachina D.3

1Universidad de Valencia-CIBERehd, Department of Pharmacology, Valencia, Spain 2Universidad de Valencia, Department of Medicine, Valencia, Spain 3Universidad de Valencia, Department of Pharmacology, Valencia, Spain 4FISABIO Hospital Peset, Department of Pharmacology, Valencia, Spain

P016: Pregnancy in IBD: direct effect of sex-hormones on epithelial barrier functionECCO '17 Barcelona
Year: 2017
Authors:

van der Giessen J., van der Woude C., Peppelenbosch M., Fuhler G.

Erasmus Medical Center, Gastroenterology and Hepatology, Rotterdam, Netherlands

P017: OGR1 (GPR68) expression is increased in intestinal inflammation and correlates with disease activity in patients with IBDECCO '17 Barcelona
Year: 2017
Authors:

Cosin-Roger J.1, Bengs S.1, Lang S.1, Turina M.2, Rickenbacher A.2, Seuwen K.3, Ruiz P.A.1, Misselwitz B.1, Rogler G.1, de Vallière C.*1

1University Hospital Zurich, University of Zurich, Gastroenterology and Hepatology, Zurich, Switzerland 2University Hospital Zurich, Clinic of Visceral and Transplantation Surgery, Zurich, Switzerland 3Novartis Institutes for Biomedical Research, Basel, Switzerland

P018: Complete metabonomic and microbiota profiling identifies biomarkers for anti-TNF therapy responseECCO '17 Barcelona
Year: 2017
Authors:

Ding N.S.*1,2,3, Sarafian M.3,4, Perdones-Montero A.5, Misra R.4, Hendy P.4, Penez L.4, Holmes E.3, Hart A.3,4

1St Vincent's Hospital, Inflammatory Bowel Disease, Melbourne, Australia 2St Mark's Hospital, Inflammatory Bowel Disease Unit, London, United Kingdom 3Imperial College London, Department of Surgery and Cancer, London, United Kingdom 4St Mark's Hospital, IBD, London, United Kingdom 5Imperial College, Surgery and Cancer, London, United Kingdom

P019: Anti-TNF-alpha therapy induces microbial and immunological changes in dextran sodium sulphate chronic colitisECCO '17 Barcelona
Year: 2017
Authors:

Petito V.*1, Graziani C.1, Lopetuso L.1, Quaranta G.2, Paroni Sterbini F.2, Masucci L.2, Sgambato A.3, Cammarota G.1, Sanguinetti M.2, Gasbarrini A.1, Scaldaferri F.1

1Fondazione Policlinico Universitario Gemelli, Catholic University of Sacred Heart, Gastroenterological Area, Gastroenterological and Endocrino-Metabolical Sciences Department, ROME, Italy 2Catholic University of Sacread Hearth, “A. Gemelli” Hospital, Department of Microbiology, Rome, Italy 3Catholic University of Sacred Heart of Rome, Department of Pathology, Rome, Italy

P020: Wnt5b could contribute to regeneration of the epithelium in inflammatory bowel disease by potentiating epithelial mesenchymal transitionECCO '17 Barcelona
Year: 2017
Authors:

Dotti I.*1, Ferrer-Picόn E.1, Planell N.1,2, van Herk E.H.3, Cuatrecasas M.4, Panés J.5, Salas A.1

1IDIBAPS, Experimental Gastroenterology, Barcelona, Spain 2CIBERehd, Barcelona, Spain 3Academic Medical Center (AMC), Tytgat Institute for Liver and Intestinal Research, Amsterdam, Netherlands 4Hospital Clinic de Barcelona, Department of Pathology, Barcelona, Spain 5Hospital Clinic de Barcelona, Department of Gastroenterology, Barcelona, Spain

P021: Utility of therapeutic anti-TNF drug monitoring in hospitals with different degree of experience in the treatment of inflammatory bowel diseaseECCO '17 Barcelona
Year: 2017
Authors:

Vila M.*1, Bahi A.1, Miquel J.O.2, Busquets D.3, Salό J.2, Aldeguer X.3

1Dr. Josep Trueta University Hospital, Institute of biomedical investigation of Girona, Girona, Spain 2Vic University Hospital, Gastroenterology, Vic, Spain 3Dr. Josep Trueta University Hospital, Gastroenterology, Girona, Spain

P022: MET deletion in MRP8+ neutrophils is protective during DDS-induced colitis via Th17 pathwayECCO '17 Barcelona
Year: 2017
Authors:

Stakenborg M., Meroni E., Goverse G., Matteoli G.

KU Leuven, P.O. Box 701, Department of Clinical and Experimental Medicine, Leuven, Belgium

P023: Fatigue in quiescent inflammatory bowel disease is associated with low GM-CSF levels and metabolomic alterationsECCO '17 Barcelona
Year: 2017
Authors:

Borren N.*1,2, Goel G.3,4, Lassen K.1, Devaney K.1, Cleland T.1, Garber J.1,4, Khalili H.1,4, Yajnik V.1,4, Xavier R.1,4, Ananthakrishnan A.1,4

1Massachusetts General Hospital, Department of Gastroenterology, Boston, United States 2University of Groningen, Groningen, Netherlands 3Massachusetts General Hospital, Boston, United States 4Harvard Medical School, Boston, United States

P024: Stratification of ulcerative colitis patients according to distinctive tissue cytokine profilesECCO '17 Barcelona
Year: 2017
Authors:

Butera A.*1, De Nitto D.2, Ciamberlano B.3, Giuliani A.4, Pica R.2, Pronio A.5, Boirivant M.1

1Istituto Superiore di Sanità, Dept Infectious, Parasitic and Immune-mediated Diseases, Roma, Italy 2Sandro Pertini Hospital, IBD, GE Unit, Roma, Italy 3University “Sapienza”, Dept General Surgery, “P. Stefanini”, Rome, Italy 4Istituto Superiore di Sanità, Dept Environment and Health, Rome, Italy 5University “Sapienza”, Dept. General Surgery, “P. Stefanini”, Roma, Italy

P025: Transcriptional and molecular pathways activated in mesenteric adipose tissue and intestinal mucosa of Crohn's disease patientsECCO '17 Barcelona
Year: 2017
Authors:

Coope A.1, Pascoal L.B.1, Silva F.A.R.1, Botezelli J.D.1, Ayrizono M.L.S.1, Milanski M.2, Camargo M.G.1, Planell N.3, Portovedo M.2, Dias C.B.1, Fagundes J.J.1, Leal R.F.*1

1University of Campinas, Department of Surgery, IBD Research Laboratory, Campinas, Brazil 2University of Campinas, Cell Signaling Laboratory, Department of Internal Medicine, Campinas, Brazil 3IDIBAPS, CIBERehd, Bioinformatics Platform, Barcelona, Spain

P026: The role of fibrocytes in mesenteric Crohn's diseaseECCO '17 Barcelona
Year: 2017
Authors:

Kiernan M.G.*1, Sahebally S.M.1,2, Kiely P.A.1, Waldron D.2, Moloney M.3, Skelly M.3, Faul P.N.4, O'Leary D.P.2, Lowery A.J.1,2, Walsh L.G.1,2, Dunne C.P.1, Coffey J.C.1,2

1University of Limerick, Graduate Entry Medical School and Centre for Interventions in Infection, Inflammation and Immunity (4i), Limerick, Ireland 2University Hospitals Limerick, Department of Surgery, Limerick, Ireland 3University Hospitals Limerick, Department of Gastroenterology, Limerick, Ireland 4University Hospitals Limerick, Department of Pathology, Limerick, Ireland

P027: Comparing the immunological signatures of inflammatory diseasesECCO '17 Barcelona
Year: 2017
Authors:

McDonald E.*1, Wright P.1, Zangerle-Murray T.2, Jung J.1, Gaya D.3, Siebert S.1, McInnes I.1, Milling S.1

1University of Glasgow, Infection, Immunity and Inflammation, Glasgow, United Kingdom 2University of Manchester, Manchester, United Kingdom 3Glasgow Royal Infirmary, Glasgow, United Kingdom

P028: Oligonol attenuates dextran sulfate sodium-induced colitis and reduces flare-UP in mice by enhancing host defense mechanismECCO '17 Barcelona
Year: 2017
Authors:

Kim K.-J.*1, Park J.-M.2, Han Y.-M.2, Lee S.G.2, Shin S.A.2, Hahm K.-B.2

1Asan Medical Center, Gastroenterology, Seoul, South Korea 2Cha Bundang Medical Center, Cha University, Department of Gastroenterology, Seongnam-Si, South Korea

P029: Azelnidipine, a novel calcium channel blocker, ameliorates severity of colitis in DSS induced colitis in mice possibly by modulating tissue levels of TNF-alpha and IL-6ECCO '17 Barcelona
Year: 2017
Authors:

Kav T., Akyol A., Aksoy E., Ozer C., Torgutalp M., Sivri B.

Hacettepe University, Gastroenterology, Ankara, Turkey

P030: Inhibitory activity of 6-amino-2,4,5-trimethylpyridin-3-ols against inflammatory cell adhesion and recruitment to colon epitheliumECCO '17 Barcelona
Year: 2017
Authors:

Jeong B.-S.*1, Banskota S.1, Kang H.-e.2, Kim J.-A.1, Nam T.-g.2

1Yeungnam University, College of Pharmacy, Gyeongsan, South Korea 2Hanyang University, College of Pharmacy, Ansan, South Korea

P031: Identification of alternative splicing in transcript isoforms in patients with ulcerative colitis: effects of disease durationECCO '17 Barcelona
Year: 2017
Authors:

Low E.N.D.*1, Wong Z.1, Ngiu C.S.1, Nazefah A.H.2, Rafiz A.R.3, Mokhtar N.1, Raja Ali R.A.1

1Universiti Kebangsaan Malaysia, Medicine, Kuala Lumpur, Malaysia 2Universiti Sains Islam Malaysia, Medicine, Kuala Lumpur, Malaysia 3Universiti Teknologi MARA, Medicine, Kuala Lumpur, Malaysia

P032: The pharmacological profile of TOP1288, a narrow spectrum kinase inhibitor in clinical development as an anti-inflammatory treatment for ulcerative colitisECCO '17 Barcelona
Year: 2017
Authors:

Foster M.*1, Biancheri P.2, Fyfe M.1, MacDonald T.3, Rowley A.1, Sirohi S.1, Solanke Y.1, Webber S.1, Walshe C.1

1Topivert Pharma Ltd, London, United Kingdom 2University of East Anglia, Norwich Medical School, Norwich, United Kingdom 3Barts and London School of Medicine and Dentistry, Centre of Immunobiology, London, United Kingdom

P033: DSS-induced colitis is attenuated in sigma-1 receptor knockout miceECCO '17 Barcelona
Year: 2017
Authors:

Lόpez-Estévez S.*1, Aguilera M.1, Gris G.2, de la Puente B.2, Codony X.2, Zamanillo D.2, Martínez V.1

1Universitat Autònoma de Barcelona, Cell Biology, Physiology and Immumology, Bellaterra, Spain 2Esteve, Department of Pharmacology, Drug Discovery & Preclinical Development, Barcelona, Spain