P0212: Non-canonical STING signaling in intestinal epithelial cells guides DNA damage-driven stem cell function and protects from intestinal carcinogenesisECCO'25Year: 2025
Authors: Xiang, H.(1)*;Woitaske-Proske, C.(2);Bernardes, J.P.(1);Martini, G.R.(1);Wottawa, F.(1);Bornhaeuser, J.(1);Kakavand, N.(1);Guang, Y.(1);Wu, Q.(1);Kugler, J.(1);Welz, L.(1);Konukiewitz, B.(3);Peifer, C.(2);Schreiber, S.(4);Tschurtschenthaler, M.(5);Rosenstiel, P.(1);Aden, K.(1);
(1)Kiel University, Institute of Clinical Molecular Biology, Kiel, Germany;(2)Kiel University, Institute of Pharmacy, Kiel, Germany;(3)Christian-Albrechts-University and University Hospital Schleswig-Holstein- Campus Kiel, Department of Pathology, Kiel, Germany;(4)Christian-Albrechts-University and University Hospital Schleswig-Holstein- Campus Kiel, Department of Internal Medicine I, Kiel, Germany;(5)Technical University of Munich Klinikum rechts der Isar Center for Translational Cancer Research, Department of Internal Medicine II, Munich, Germany;
1. Reijns, Martin A.M., et al., Enzymatic Removal of Ribonucleotides from DNA Is Essential for Mammalian Genome Integrity and Development. Cell, 2012. 149(5): p. 1008-1022.
2. Bartsch, K., et al., Absence of RNase H2 triggers generation of immunogenic micronuclei removed by autophagy. Hum Mol Genet, 2017. 26(20): p. 3960-3972.
3. Aden, K., et al., Epithelial RNase H2 Maintains Genome Integrity and Prevents Intestinal Tumorigenesis in Mice. Gastroenterology, 2019. 156(1): p. 145-159 e19.
P0213: Salivary Veillonella parvula from Crohn's Disease Patients Exacerbates Intestinal InflammationECCO'25Year: 2025
Authors: Xiang, B.(1);Hu, J.(2);Zhi, M.(1);Xu, Z.(1)*;Zhang, M.(1);Peng, X.(1);
(1)The Sixth Affiliated Hospital of Sun Yat-Sen University, Department of Gastroenterology, Guangzhou- Guangdong, China;(2)The Sixth Affiliated Hospital of Sun Yat-Sen University, Guangdong Institute of Gastroenterology, Guangzhou- Guangdong, China;
P0214: Notch Pathway-Mediated epithelial-mesenchymal transition and Fibrosis in Complicated Crohn’s DiseaseECCO'25Year: 2025
Authors: Patel, J.(1);Cejudo-Garcés, A.(1);Jarén, A.(1)*;Macias-Ceja, D.C.(1);Manresa, M.(2);López, A.(3,4);Cosin-Roger, J.(1,5);Calatayud, S.(1,5);Barrachina, M.D.(1,5);Ortiz-Masiá, D.(5,6,7);
(1)Universitat de València, Pharmacology department, Valencia, Spain;(2)University College Dublin, School of Biomolecular and Biomedical Science, Dublin, Ireland;(3)Universitat de València, Medicina department, Valencia, Spain;(4)Hospital Universitario Doctor Peset, Digestivo, Valencia, Spain;(5)Centro de investigaciones en red CIBER, Enfermedades hepáticas y digestivas, Valencia, Spain;(6)Universitat de València, Medicine department, Valencia, Spain;(7)Grupo español de trabajo en enfermedad de Crohn y Colitis GETECCU, Grupo de investigación básica y traslacional, Madrid, Spain;
M Rodriguez-Antequera, J Cosin-Roger, D Macias-Ceja, P Salvador, L Gisbert-Ferrándiz, S Coll, J Manyé, R Alós, F Navarro-Vicente, S Calatayud, M D Barrachina, D Ortiz-Masia, P041 Differences in NOTCH signalling between stricturing and penetrating behaviour in Crohn’s disease, Journal of Crohn's and Colitis, Volume 13, Issue Supplement_1, March 2019, Page S107, https://doi.org/10.1093/ecco-jcc/jjy222.165
P0215: Food avoidance and symptom triggers in patients with Ulcerative Colitis while in remissionECCO'25Year: 2025
Authors: Ayton, D.(1)*;Hoque , S.(1);
(1)Whipps Cross University Hospital - Barts Health NHS Trust, Gastroenterology, London, United Kingdom;
1. Norman E, Hoque S. P185 Food avoidance and dietary restrictions in patients with Inflammatory Bowel Disease. J Crohns Colitis. 2024;18(Suppl 1) doi:10.1093/ecco-jcc/jjad212.0315.
2. World Gastroenterology Organisation. Test for Diagnosing IBS. Published 2009. Available at: https://www.worldgastroenterology.org/UserFiles/file/wdhd-2009-test-for-diagnosing-ibs.pdf
P0216: PANoptosis-related genes can predict the progression of ulcerative colitis and colitis-associated colorectal cancer.ECCO'25Year: 2025
Authors: Li, Y.(1)*;Zheng, S.(1);Yan, Q.(1);Zhong, X.(1);
(1)The Affiliated Hospital of Southwest Medical University, Department of Gastroenterology, Luzhou, China;
Nature. 2007;448(7152):427-434. doi:10.1038/nature060052. Jess T, Rungoe C, Peyrin L. Risk of Colorectal Cancer in Patients With Ulcerative Colitis: A Meta-analysis of Population-Based Cohort Studies. 2012;10(6).3. Shin J, Baek GH, Cha B, et al. Complementary Therapeutic Effect of Fecal Microbiota Transplantation in Ulcerative Colitis after the Response to Anti-Tumor Necrosis Factor Alpha Agent Was Lost: A Case Report. Published online 2024. doi:10.3390/biomedicines12040800Front Cell Infect Microbiol. 2019;9:406. doi:10.3389/fcimb.2019.00406J Immunol. 2022;209(9):1625-1633. doi:10.4049/jimmunol.2200508World J Gastroenterol. 2014;20(44):16389. doi:10.3748/wjg.v20.i44.16389
P0217: Colonic stromal cells are a source of sphingosine-1-phosphate and may be defining responsiveness to sphingosine-1-phosphate receptor modulators in Ulcerative ColitisECCO'25Year: 2025
Authors: Drygiannakis, I.(1,2)*;Damianaki, A.(1);Filidou, E.(3);Theodoraki, E.(2);Coucoutsi, C.(2);Foteinogiannopoulou, K.(2);Spathakis, M.(3);Kandilogiannakis, L.(3);Dovrolis, N.(3);Kolios, G.(3);Valatas, V.(1,2);Koutroubakis, I.(1,2);
(1)University of Crete, School of Medicine, Heraklion, Greece;(2)Heraklion University Hospital, Department of Gastroenterology, Heraklion, Greece;(3)Democritus University of Thrace, Department of Medicine, Alexandroupolis, Greece;
P0218: Dietary Inflammatory Index and disease activity in patients with IBD: is there an association? A Preliminary AnalysisECCO'25Year: 2025
Authors: Soares, C.(1)*;Martins, D.(2);Sousa, P.(2);Cancela, E.(2);Martins, S.(3);Torres, D.(4);Ministro, P.(2);
(1)Centro Hospitalar Tondela Viseu, Gastroenterology, VISEU, Portugal;(2)Centro Hospitalar Tondela-Viseu, Gastroenterology, Viseu, Portugal;(3)University of Porto, Institute of Public Health, Porto, Portugal;(4)Faculty of Nutrition and Food Sciences, University of Porto, Porto, Portugal;
1 Kaplan GG, Windsor JW. The four epidemiological stages in the global evolution of inflammatory bowel disease. Nat Rev Gastroenterol Hepatol. 2021 Jan;18(1):56-66.
2 Adolph TE, Zhang J. Diet fuelling inflammatory bowel diseases: preclinical and clinical concepts. Gut. 2022 Dec;71(12):2574-2586.
3 Adolph TE, Meyer M, Schwärzler J, Mayr L, Grabherr F, Tilg H. The metabolic nature of inflammatory bowel diseases. Nat Rev Gastroenterol Hepatol. 2022 Dec;19(12):753-767. 4 Sh Shivappa N, Steck SE, Hurley TG, Hussey JR, Hébert JR. Designing and developing a literature-derived, population-based dietary inflammatory index. Public Health Nutr. 2014 Aug;17(8):1689-96.
P0219: The role of IP10 as a possible biomarker of Short Bowel Syndrome: a preliminary studyECCO'25Year: 2025
Authors: Pane, C.(1)*;Di Mattia, M.(1);Petito, V.(2);Foscarini, E.(3);Profeta, F.(3);Becherucci, G.(3);Masi, L.(2);Troisi, S.(1,2);Emoli, V.(2);Rondinone, B.(2);Turchini, L.(3);Gasbarrini, A.(2,3,4);Papa, A.(3,4);Scaldaferri, F.(2,3,4);Lopetuso, L.R.(1,2,3,5);
(1)Center for Advanced Studies and Technology CAST- “G. d’Annunzio” University of Chieti-Pescara, Medicina e Scienze dell'Invecchiamento, Chieti, Italy;(2)CeMAD Translational Research Laboratories- Digestive Disease Center CeMAD- Fondazione Policlinico Universitario “A. Gemelli” IRCCS, Department of Medical and Surgical Sciences, Rome, Italy;(3)IBD Unit- Digestive Disease Center CeMAD- Fondazione Policlinico Universitario “A. Gemelli” IRCCS, Department of Medical and Surgical Sciences, Rome, Italy;(4)Catholic University of the Sacred Heart, Department of Translational Medicine and Surgery, Rome, Italy;(5)“G. d’Annunzio” University of Chieti-Pescara, Department of Medicine and Ageing Sciences, Chieti, Italy;
- Massironi S, Cavalcoli F, Rausa E, Invernizzi P, Braga M, Vecchi M. Understanding short bowel syndrome: Current status and future perspectives. Dig Liver Dis. 2020;52(3):253-261. doi:10.1016/j.dld.2019.11.013
- Pironi L, Konrad D, Brandt C, et al. Clinical classification of adult patients with chronic intestinal failure due to benign disease: An international multicenter cross-sectional survey. Clin Nutr. 2018;37(2):728-738. doi:10.1016/j.clnu.2017.04.013
- Limketkai BN, Parian AM, Shah ND, Colombel JF. Short Bowel Syndrome and Intestinal Failure in Crohn's Disease. Inflamm Bowel Dis. 2016;22(5):1209-1218. doi:10.1097/MIB.0000000000000698
- Devito A. Alpha chemokines in Crohn's disease. Clin Ter. 2015;166(2):e114-e117. doi:10.7417/CT.2015.1832
Fundings: 2.1 "Rafforzamento e potenziamento della ricerca biomedica del SSN", finanziato dall’Unione europea – NextGenerationEU, CUP C53C22001140007. 2022 PNRR Project "Changing the future of intestinal failure in intestinal chronic inflammation: towards innovative predictive factors and therapeutic targets" code: PNRR-MAD-2022-12376791.
P0220: Anti-TNFα, anti-integrin α4β7 and anti-IL23p19 biologic treatment dose optimization in a dextran sodium sulphate (DSS)-induced colitis mouse modelECCO'25Year: 2025
Authors: Suarez-Trujillo, F.(1)*;Orejudo, M.(1);Soleto, I.(1);Ramírez, C.(1);Baldán-Martín, M.(1);Martínez, P.J.(1);Gordillo-Vélez, C.H.(2);Cibrián, D.(3);P. Gisbert*, J.(1);Chaparro*, M.(1);
(1)Servicio de Aparato Digestivo. Hospital Universitario de La Princesa- Instituto de Investigación Sanitaria Princesa IIS-Princesa- Universidad Autónoma de Madrid UAM- and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas CIBEREHD- Madrid. Spain, Servicio de Aparato Digestivo, Madrid, Spain;(2)Servicio de Anatomía Patológica. Hospital Universitario de La Princesa- Madrid- Spain, Servicio de Anatomía Patológica, Madrid, Spain;(3)Servicio de Inmunología. Hospital Universitario de La Princesa- Instituto de Investigación Sanitaria Princesa IIS-Princesa- Centro Nacional de Investigaciones Cardiovasculares CNIC- and Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares CIBERCV- Madrid. Spain, Servicio de Inmunología, Madrid, Spain; *These authors share senior authorship
P0221: The role of caffeine and its metabolites in the modulation of intestinal inflammation and epithelial barrier integrityECCO'25Year: 2025
Authors: Kulokiene, U.(1)*;Inciuraite, R.(1);Butaite, G.(1);Salteniene, V.(1);Kiudelis, V.(2);Jonaitis, L.V.(2);Kiudelis, G.(2);Kupcinskas, J.(2);Skieceviciene, J.(1);
(1)Lithuanian University of Health Sciences, Institute for Digestive Research, Kaunas, Lithuania;(2)Lithuanian University of Health Sciences, Institute for Digestive Research and Department of Gastroenterology, Kaunas, Lithuania;
Reddy V. S. et al. (2024) Pharmacology of caffeine and its effects on the human body. European Journal of Medicinal Chemistry Reports, 10 (100138). https://doi.org/10.1016/j.ejmcr.2024.100138.
P0222: Predicting corticosteroid failure in Acute Severe Ulcerative Colitis at admission using the ADMIT-ASC score.ECCO'25Year: 2025
Authors: Chan, P.(1)*;Ajmera, R.(1);Thin, L.(1,2);
(1)Fiona Stanley Hospital, Department of Gastroenterology, Murdoch, Australia;(2)Harry Perkins Institute of Medical Research, IBD Clinical Trials Unit, Murdoch, Australia;
[1] Adams, A., Gupta, V., Mohsen, W., Chapman, T. P., Subhaharan, D., Ramaswamy, P. K., ... & Satsangi, J. (2023). Early management of acute severe UC in the biologics era: development and international validation of a prognostic clinical index to predict steroid response. Gut, 72(3), 433-442.Chicago
[2] Ho, G. T., Mowat, C., Goddard, C. J. R., Fennell, J. M., Shah, N. B., Prescott, R. J., & Satsangi, J. (2004). Predicting the outcome of severe ulcerative colitis: development of a novel risk score to aid early selection of patients for second‐line medical therapy or surgery. Alimentary pharmacology & therapeutics, 19(10), 1079-1087.
P0223: In Vitro Fertilization in Women with Inflammatory Bowel Disease – Clinical Characteristics and OutcomesECCO'25Year: 2025
Authors: Ashkenazi, A.(1)*;Ron, Y.(2);Skornick-Rapaport, A.(2);Leibovitzh, H.(2);Thurm, T.(2);Hirsch, A.(2);Maharshak, N.(2);Cohen, N.A.(2);
(1)Tel Aviv Sourasky Medical Center - Ichilov, IBD center- Department of Gastroenterology and Liver Disesaes, Tel-Aviv, Israel;(2)Tel Aviv Sourasky Medical Center - Ichilov, IBD Center- Department of Gastroenterology and Liver Diseases, Tel Aviv, Israel;
P0224: Learning Curve in Intestinal Ultrasound: Advancing from Basic Skills to Advanced Competencies – Insights from the IUS IG-IBD (Italian Group for the Study of Inflammatory Bowel Disease) Master ProgramECCO'25Year: 2025
Authors: Bezzio, C.(1);Pitoni, D.(2);Ribaldone, D.G.(2);Vernero, M.(2)*;Castiglione, F.(3);Rispo, A.(3);Saibeni, S.(4);Maconi, G.(5);Terracciano, F.(6);Bossa, F.(7);Allocca, M.(8);Furfaro, F.(8);Calabrese, E.(9);Zorzi, F.(9);Fraquelli, M.(10);Caprioli, F.(10);Rizzello, F.(11);Mazzotta, E.(11);Orlando, A.(12);Grova, M.(12);Massironi, S.(8);Viganò, C.(13);Armuzzi, A.(1);
(1)IRCCS Humanitas Research Hospital, Gastroenterology, Milan, Italy;(2)City of Health and Science University Hospital, Gastroenterology, Turin, Italy;(3)Azienda Ospedaliera Universitaria Policlinico Federico II, Gastroenterology, Naples, Italy;(4)ASST Rhodense, Gastroenterology, Rho, Italy;(5)ASST Fatebenefratelli Sacco, Gastroenterology, Milan, Italy;(6)Ospedale Casa Sollievo della Sofferenza, Gastroenterology, San Giovanni Rotondo, Italy;(7)Casa Sollievo della Sofferenza, Gastroenterology, San Giovanni Rotondo, Italy;(8)IRCCS Ospedale San Raffaele, Gastroenterology, Milan, Italy;(9)Policlinico Tor Vergata, Gastroenterology, Rome, Italy;(10)Policlinico di Milano Ospedale Maggiore, Gastroenterology, Milan, Italy;(11)Policlinico S. Orsola - Malpighi, Gastroenterology, Bologna, Italy;(12)Ospedali Riuniti Villa Sofia - Cervello, Gastroenterology, Palermo, Italy;(13)IRCCS San Gerardo dei Tintori, Gastroenterology, Monza, Italy;
P0225: Histone Serotonylation (H3Q5ser): A Novel Epigenetic Signature in Crohn’s Disease PathogenesisECCO'25Year: 2025
Authors: Li, J.(1,2)*;Overberg, K.(1,2);Metselaar, P.(1,2);te Velde, A.(1,2);Löwenberg, M.(3);D'Haens, G.(3);Derikx, J.(4);de Jonge, W.(1,2,5);Ghiboub, M.(1,2,4);
(1)Tytgat Institute for Liver and Intestinal Research- Amsterdam Gastroenterology Endocrinology Metabolism, Amsterdam University Medical Center- University of Amsterdam, Amsterdam, The Netherlands;(2)Amsterdam Gastroenterology Endocrinology Metabolism Institute, Amsterdam University Medical Center, Amsterdam, The Netherlands;(3)Department of Gastroenterology and Hepatology, Amsterdam University Medical Centers, Amsterdam, The Netherlands;(4)Emma Children's Hospital- Pediatric Surgery, Amsterdam University Medical Center- University of Amsterdam, Amsterdam, The Netherlands;(5)Department of Surgery, University of Bonn, Bonn, Germany;
